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AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin

Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD

  • KMID: 755672
  • Exp Mol Med.
  • 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity...
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Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells

Lee YM, Kim W

  • KMID: 755671
  • Exp Mol Med.
  • 2004 Feb;36(1):93-97.
In association with microtubules, a variety of kinesins play important roles in cellular functions such as intracellular transport of organelles or vesicles, signal transduction, and cell division. In a previous...
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Increased methylation of the cytosolic 20-kD protein is accompanied by liver regeneration in a hepatectomized rat

Kwon SY, Kim S, Lee K, Kim TJ, Lee SH, Lee KM, Park GH

  • KMID: 755670
  • Exp Mol Med.
  • 2004 Feb;36(1):85-92.
Arginine methylation has been implicated in the signal transduction pathway leading to cell growth. Here we show that a regenerating rat liver following partial hepatectomy exhibited elevated methyltransferase activity as...
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Methyl-beta-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway

Choi YA, Chin BR, Rhee DH, Choi HG, Chang HW, Kim JH, Baek SH

  • KMID: 755669
  • Exp Mol Med.
  • 2004 Feb;36(1):78-84.
Methyl-beta-cyclodextrin, a cyclic oligosaccharide known for its interaction with the plasma membrane induces several events in cells including cell growth and anti-tumor activity. In this study, we have investigated the...
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Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells

Wan J, Bae MA, Song BJ

  • KMID: 755668
  • Exp Mol Med.
  • 2004 Feb;36(1):71-77.
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify...
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Angiotensin II receptor blocker attenuates overexpression of vascular endothelial growth factor in diabetic podocytes

Lee EY, Shim MS, Kim MJ, Hong SY, Shin YG, Chung CH

  • KMID: 755667
  • Exp Mol Med.
  • 2004 Feb;36(1):65-70.
VEGF expressed in glomerular podocytes, is known to increase vascular permeability to macromolecules. Angiotensin II can stimulate the release of VEGF, and the protective effects of angiotensin II antagonist against...
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Involvement of MAPK pathway in hypoxia-induced up-regulation of urokinase plasminogen activator receptor in a human prostatic cancer cell line, PC3MLN4

Lee KH, Choi EY, Hyun MS, Kim JR

  • KMID: 755666
  • Exp Mol Med.
  • 2004 Feb;36(1):57-64.
Clinical studies have shown that tumor hypoxia is associated with invasive growth and metastasis and may be an important prognostic factor adversely influencing survival in patients with tumors. To investigate...
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Forskolin promotes astroglial differentiation of human central neurocytoma cells

Kim BJ, Kim SS, Kim YI, Paek SH, Lee YD, Suh-Kim H

  • KMID: 755665
  • Exp Mol Med.
  • 2004 Feb;36(1):52-56.
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation...
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Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine

Lee H, Ryu J, Kim KA, Lee KS, Lee JY, Park JB, Park J, Choi SY

  • KMID: 755664
  • Exp Mol Med.
  • 2004 Feb;36(1):43-51.
Enzyme/prodrug approach is one of the actively developing areas for cancer therapy. In an effort to develop more effective enzyme/prodrug systems, cell-permeable cytosine deaminase was produced by fusing yeast cytosine...
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Isolation of ethanol-induced genes in pancreatic beta-cells by representational difference analysis (RDA)

Shin JS, Kwon YS, Lee JJ, Kim CW

  • KMID: 755663
  • Exp Mol Med.
  • 2004 Feb;36(1):36-42.
Recent epidemiological studies suggest that alcohol consumption is one of the risk factors leading to type 2 diabetes, but the direct effect of ethanol on beta-cell gene expression is not...
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Hereditary neuropathy with liability to pressure palsies (HNPP) patients of Korean ancestry with chromosome 17p11.2-p12 deletion

Kim SM, Chung KW, Choi BO, Yoon ES, Choi JY, Park KD, Sunwoo IN

  • KMID: 755662
  • Exp Mol Med.
  • 2004 Feb;36(1):28-35.
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant inherited disorder characterized by recurrent pressure palsies. Most HNPP patients have a 1.5 mb deletion in chromosome 17p11.2-p12....
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Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats

Sun H, Zhang L, Wang A, Xue Z

  • KMID: 755661
  • Exp Mol Med.
  • 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery...
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Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis

Jung HW, Choi SW, Choi JI, Kwon BS

  • KMID: 755660
  • Exp Mol Med.
  • 2004 Feb;36(1):13-22.
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease whose etiopathogenesis is not well understood. Although soluble (s) forms of 4-1BB (s4-1BB) and 4-1BB legand (s4-1BBL) have been detected in the...
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Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions

Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW

  • KMID: 755659
  • Exp Mol Med.
  • 2004 Feb;36(1):1-12.
Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian development. HIF-1 consists of a constitutively expressed HIF-1beta subunit and one...
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