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Transgenic expression of Korean type hepatitis C virus core protein and related mutants in mice

Wang AG, Moon HB, Lee YH, Yu SL, Kwon HJ, Han YH, Fang W, Lee TH, Jang KL, Kim SK, Yu DY, Lee DS

  • KMID: 1103328
  • Exp Mol Med.
  • 2004 Dec;36(6):588-592.
Hepatitis C virus (HCV) is a major causative agent in liver disease. In order to investigate if Korean type HCV core protein and its related mutants, S99Q and S116I, are...
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beta PAK-interacting exchange factor may regulate actin cytoskeleton through interaction with actin

Lee CS, Kim KY, Im JB, Choi JW, Kim HK, Park JS, Shin EY, Kim SR, Kim EG

  • KMID: 1103327
  • Exp Mol Med.
  • 2004 Dec;36(6):582-587.
p21-activated kinase (PAK)-interacting exchange factor (PIX) is known to be involved in regulation of Cdc42/Rac GTPases and PAK activity. PIX binds to the proline-rich region of PAK, and regulates biological...
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Different inhibition characteristics of intracellular transglutaminase activity by cystamine and cysteamine

Jeon JH, Lee HJ, Jang GY, Kim CW, Shin DM, Cho SY, Yeo EJ, Park SC, Kim IG

  • KMID: 1103326
  • Exp Mol Med.
  • 2004 Dec;36(6):576-581.
The treatment of cystamine, a transglutaminase (TGase) inhibitor, has beneficial effects in several diseases including CAG-expansion disorders and cataract. We compared the inhibition characteristics of cystamine with those of cysteamine,...
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Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients

Deligezer , Dalay N

  • KMID: 1103325
  • Exp Mol Med.
  • 2004 Dec;36(6):572-575.
The X-ray repair cross-complementing group 1 (XRCC1) gene is believed to play an important role in base excision repair and displays genetic polymorphisms. Data on the role of XRCC1 polymorphisms...
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The nuclear 16-kD protein methylation increases in the early period of liver regeneration in a hepatectomized rat

Lee K, Lee KM, Kim TJ, Han JS, Kim MK, Hong YS, Park GH, Lee KW

  • KMID: 1103324
  • Exp Mol Med.
  • 2004 Dec;36(6):563-571.
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. We observed that methyltransferase activity underwent time-dependent changes in the cytosol of the...
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p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells

Park KS, Jeon SH, Oh JW, Choi KY

  • KMID: 1103323
  • Exp Mol Med.
  • 2004 Dec;36(6):557-562.
p21Cip/WAF1, an important regulator of cell proliferation, is induced by both p53- and extracellular signal regulated kinase (ERK) pathways. The induction of p21Cip/WAF1 occurs by prolonged activation of the ERKs...
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Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells

Gong X, Wang M, Wu Z, Tashiro SI, Onodera S, Ikejima T

  • KMID: 1103322
  • Exp Mol Med.
  • 2004 Dec;36(6):551-556.
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We observed that pseudolaric acid B inhibited cell proliferation and...
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Corn silk induces nitric oxide synthase in murine macrophages

Kim KA, Choi SK, Choi HS

  • KMID: 1103321
  • Exp Mol Med.
  • 2004 Dec;36(6):545-550.
Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric...
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Ox-LDL suppresses PMA-induced MMP-9 expression and activity through CD36-mediated activation of PPAR-gamma

Lee KJ, Kim HA, Kim PH, Lee HS, Ma KR, Park JH, Kim DJ, Hahn JH

  • KMID: 1103320
  • Exp Mol Med.
  • 2004 Dec;36(6):534-544.
During chronic inflammatory response, mono- cytes/macrophages produce 92-kDa matrix metalloproteinase-9 (MMP-9), which may contribute to their extravasation, migration and tissue remodeling. Activation of peroxisome proliferator- activated factor receptor-gamma (PPAR-gamma) has...
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Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm

Paik DC, Fu C, Bhattacharya J, David Tilson M

  • KMID: 1103319
  • Exp Mol Med.
  • 2004 Dec;36(6):524-533.
Pathogenesis of the abdominal aortic aneurysm has been attributed to neovascularization of the aortic wall. However, it is not clear whether angiogenesis persists in the aneurysm. In sections of aneurysms,...
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5-azacytidine induces cardiac differentiation of P19 embryonic stem cells

Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS

  • KMID: 1103318
  • Exp Mol Med.
  • 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of...
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The upstream sequence of Mycobacterium leprae 18-kDa gene confers transcription repression activity in orientation-independent manner

Kim HB, You JC

  • KMID: 1103317
  • Exp Mol Med.
  • 2004 Dec;36(6):510-514.
In order to understand the role of the upstream region of the Mycobacterium leprae 18-kDa gene on the gene regulation, the region was divided into two at the -50 position...
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The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER)

Seo YR, Jung HJ

  • KMID: 1103316
  • Exp Mol Med.
  • 2004 Dec;36(6):505-509.
The p53 tumor suppressor has long been envisaged to preserve genetic stability by the induction of cell cycle checkpoints and apoptosis. More recently, p53 has been implicated to play roles...
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