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Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells

Shin SY, Kim CG, Hong DD, Kim JH, Lee YH

  • KMID: 1094083
  • Exp Mol Med.
  • 2004 Aug;36(4):380-386.
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cell growth, differentiation and apoptosis. Egr-1 has been shown to be down-regulated in many...
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IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Yu SJ, Kim HS, Cho SW, Sohn J

  • KMID: 1094082
  • Exp Mol Med.
  • 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the...
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Expression of the IKr components KCNH2 (rERG) and KCNE2 (rMiRP1) during late rat heart development

Chun KR, Koenen M, Katus HA, Zehelein J

  • KMID: 1094081
  • Exp Mol Med.
  • 2004 Aug;36(4):367-371.
To understand molecular mechanisms that regulate formation and maintenance of cardiac IKr (rapidly activating component of the delayed rectifier K+ current), we have investigated the spatiotemporal expression pattern of two...
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The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement

Begum R, Nur-E-Kamal MSA, Zaman MA

  • KMID: 1094080
  • Exp Mol Med.
  • 2004 Aug;36(4):358-366.
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the...
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Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat

Kimura M, Lehmann K, Gopalan-Kriczky P, Lotlikar P

  • KMID: 1094079
  • Exp Mol Med.
  • 2004 Aug;36(4):351-357.
Effects of diets on hepatic aflatoxin B1 (AFB1)- DNA binding and AFB1-induced glutathione S- transferase placental (GST-P) form positive hepatic foci have been examined in young male Fischer rats. Animals...
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Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Ergen HA, Hatemi H, Agachan B, Camlica H, Isbir T

  • KMID: 1094078
  • Exp Mol Med.
  • 2004 Aug;36(4):345-350.
Non-insulin dependent diabetes mellitus is often associated with some complications such as nephropathy, retinopathy and neuropathy. Genes of the renin angiotensin system are potential candidate genes for diabetic complications. We...
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Vascular endothelial growth factor-induced angiogenic gene therapy in patients with peripheral artery disease

Kim HJ, Jang SY, Park JI, Byun J, Kim DI, Do YS, Kim JM, Kim S, Kim BM, Kim WB, Kim DK

  • KMID: 1094077
  • Exp Mol Med.
  • 2004 Aug;36(4):336-344.
This phase 1 clinical trial tested the safety of intramuscular gene transfer by using naked plasmid DNA encoding the gene for VEGF, and analyzed the potential therapeutic benefits in patients...
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Cellular characteristics of primary and immortal canine embryonic fibroblast cells

You S, Moon JH, Kim TK, Kim SC, Kim JW, Yoon DH, Kwak S, Hong KC, Choi YJ, Kim H

  • KMID: 1094076
  • Exp Mol Med.
  • 2004 Aug;36(4):325-335.
Using normal canine embryonic fibroblasts (CaEF) that were shown to be senescent at passages 7th-9th, we established two spontaneously immortalized CaEF cell lines (designated CGFR-Ca-1 and -2) from normal senescent...
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Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of I kappa B

Chang K, Lee SJ, Cheong I, Billiar TR, Chung HT, Han JA, Kwon YG, Ha KS, Kim YM

  • KMID: 1094075
  • Exp Mol Med.
  • 2004 Aug;36(4):311-324.
The expression of inducible nitric oxide synthase (iNOS) is a critical factor in both normal physiological functions and the pathogenesis of disease. This study was undertaken to determine the molecular...
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Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction

Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ

  • KMID: 1094074
  • Exp Mol Med.
  • 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides...
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PKC alpha induces differentiation through ERK1/2 phosphorylation in mouse keratinocytes

Seo HR, Kwan YW, Cho CK, Bae S, Lee SJ, Soh JW, Chung HY, Lee YS

  • KMID: 1094073
  • Exp Mol Med.
  • 2004 Aug;36(4):292-299.
Epidermal keratinocyte differentiation is a tightly regulated stepwise process that requires protein kinase C (PKC) activation. Studies on cultured mouse keraitnocytes induced to differentiate with Ca2+ have indirectly implicated the...
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Transforming variant of Met receptor confers serum independence and anti-apoptotic property and could be involved in the mouse thymic lymphomagenesis

Baek CM, Jeon SH, Jang JJ, Lee BS, Lee JH

  • KMID: 1094072
  • Exp Mol Med.
  • 2004 Aug;36(4):283-291.
Met tyrosine kinase receptor, the receptor of hepatocyte growth factor/scatter factor (HGF/SF), is present in mouse tissues as two major isoforms differing by a 47-aminoacid segment in the juxtamembrane domain...
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