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Synergistic activation of p70S6 kinase associated with stem cell factor in MO7e cells

Lee Y, Broxmeyer , Mantel C, Kwon HJ, Kim JW, Kim JS, Kwon D, Choe IS

  • KMID: 1094704
  • Exp Mol Med.
  • 2003 Jun;35(3):222-226.
Stem cell factor (SCF) is an early-acting cytokine inducing proliferative synergy with other cytokines in hematopoietic cells. We earlier showed that p21 was synergistically induced in SCF synergy and the...
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Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1

Kim JS, Kwon HY, Choi WH, Jeon CY, Kim JI, Kim J, Lee JY, Kim YS, Park JB

  • KMID: 1094703
  • Exp Mol Med.
  • 2003 Jun;35(3):211-221.
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase...
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Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction

Kim HS, Song M, Kim E, Ryu SH, Suh PG

  • KMID: 1094702
  • Exp Mol Med.
  • 2003 Jun;35(3):203-210.
Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, immune modulation and differentiation. Moreover, the...
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Association of transforming growth factor-b1 gene polymorphisms with a hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection

Kim YJ, Lee HS, Im JP, Min BH, Kim HD, Jeong JB, Yoon JH, Kim CY, Kim MS, Kim JY, Jung JH, Kim LH, Park BL, Shin HD

  • KMID: 1094701
  • Exp Mol Med.
  • 2003 Jun;35(3):196-202.
Transforming growth factor-b1 (TGF-beta 1) can act as both a tumor suppressor and a stimulator of tumor progression. We have examined the relationship between polymorphisms of the TGF-beta 1 gene...
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Angiotensin converting enzyme gene polym orphism in Korean patients with primary knee osteoarthritis

Hong SJ, Yang HI, Yoo MC, In CS, Yim SV, Jin SY, Choe BK, Chung JH

  • KMID: 1094700
  • Exp Mol Med.
  • 2003 Jun;35(3):189-195.
Angiotensin converting enzyme (ACE) plays an important role in the physiology of vasculature, blood pressure and inflammation. ACE gene, known to have insertion/deletion (I/D) polymorphism, has been widely investigated in...
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Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis

Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H

  • KMID: 1094699
  • Exp Mol Med.
  • 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells...
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Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage

Shin HH, Lee HW, Choi HS

  • KMID: 1094698
  • Exp Mol Med.
  • 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide...
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High extracellular Ca2+ alone stimulates osteoclast formation but inhibits in the presence of other osteoclastogenic factors

Shin MM, Kim YH, Kim SN, Kim GS, Baek JH

  • KMID: 1094697
  • Exp Mol Med.
  • 2003 Jun;35(3):167-174.
High ambient Ca2+ at bone resorption sites have been implicated to play an important role in the regulation of bone remodeling. The present study was performed to clarify the mode...
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Expression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium

Rhee HS, Oh SH, Ko BJ, Han DM, Jeon BH, Park H, Moon HB, Kim WS

  • KMID: 1094696
  • Exp Mol Med.
  • 2003 Jun;35(3):160-166.
The enzyme complex 3b-hydroxysteroid dehydrogenase/delta(5)-delta(4)-isomerase (3beta-HSD) is involved in the biosynthesis of all classes of active steroids. The expression of 3beta-HSD in human uterine endometrium during the menstrual cycle and...
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Newly dentified members of the TNF recept or superfamily (mTNFRH1 and mTNFRH2) inhibit T-cell proliferation

Kim J, La S, Kim BS, Kwon BS, Kwon B

  • KMID: 1094695
  • Exp Mol Med.
  • 2003 Jun;35(3):154-159.
By searching an EST database, we identified two TNF receptor superfamily members (named mTNFRH1 and mTNFRH2). Amino acid sequences are highly conserved between the two receptors (78% identity). The chromosomal...
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Mouse models for telomere and telomerase biology

Cheong C, Hong KU, Lee HW

  • KMID: 1094694
  • Exp Mol Med.
  • 2003 Jun;35(3):141-153.
Telomeres serve a critical role in maintenance of genomic stability in all eukaryotes, from yeast to human. The maintenance of telomeres is achieved by the telomerase complex, which is largely...
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