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Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic beta-cell damage

Han MK

  • KMID: 1097262
  • Exp Mol Med.
  • 2003 Apr;35(2):136-139.
Cytokines produced by immune cells infiltrating pancreatic islets have been implicated as one of the important mediators of beta-cell destruction in insulin-dependent diabetes mellitus. In this study, the protective effects...
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Partial rescue of the Na+-Ca2+ exchanger (NCX1) knock-out mouse by transgenic expression of NCX1

Cho CH, Lee SY, Shin HS, Philipson , Lee CO

  • KMID: 1097261
  • Exp Mol Med.
  • 2003 Apr;35(2):125-135.
The null mutation of cardiac Na+-Ca2+ exchanger (NCX1) gene in mice caused death of embryo in utero at embryonic day (ED) 9.0-9.5 and this embryonic lethality appears resulted from abnormal...
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Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation

Kim YR, Cha HY, Lim K, Hwang BD, Hoe KL, Namgung U, Park SK

  • KMID: 1097260
  • Exp Mol Med.
  • 2003 Apr;35(2):118-124.
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, and acts as an inhibitor of protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be...
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De novo mutations in sporadic deletional Duchenne muscular dystrophy (DMD) cases

Mukherjee , Chaturvedi LS, Srivastava S, Mittal RD, Mittal B

  • KMID: 1097259
  • Exp Mol Med.
  • 2003 Apr;35(2):113-117.
Dinucleotide repeat polymorphism based genetic analysis is a powerful approach to gain insight into rare genetic events like germline mosaicism and de novo mutations. The loss of heterozygosity of polymorphic...
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Base excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli

Lee YS, Chung MH

  • KMID: 1097258
  • Exp Mol Med.
  • 2003 Apr;35(2):106-112.
8-oxo-7,8-dihydroguanine (8-oxo-G) in DNA is a mutagenic adduct formed by reactive oxygen species. In Escherichia coli, 2,6-dihydroxy-5N-formamidopyrimidine (Fapy)-DNA glycosylase (Fpg) removes this mutagenic adduct from DNA. In this report, we...
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Expression of hOGG1 protein during differentiation of HL-60 cells

Lee YS, Lee KH, Chung MH

  • KMID: 1097257
  • Exp Mol Med.
  • 2003 Apr;35(2):98-105.
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repair activity...
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Herba houttuyniae extract induces apoptotic death of human promyelocytic leukemia cells via caspase activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release

Kwon KB, Kim EK, Shin BC, Seo EA, Yang JY, Ryu DG

  • KMID: 1097256
  • Exp Mol Med.
  • 2003 Apr;35(2):91-97.
Herba houttuyniae has been used as a constituent of herval medicine prescriptions for the treatment of inflammation, cancer, and other diseases. In the present study, we investigated the cellular effects...
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Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells

Kang SH, Song JH, Kang HK, Kang JH, Kim SJ, Kang HW, Lee YK, Park DB

  • KMID: 1097255
  • Exp Mol Med.
  • 2003 Apr;35(2):83-90.
Arsenic trioxide (As2O3) has been found to be remarkably effective in the treatment of patients with acute promyelocytic leukemia (APL). Although evidences for the proapoptotic activity of As2O3 have been...
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Association between interleukin 6 promoter variants and chronic hepatitis B progression

Park BL, Lee HS, Kim YJ, Kim JY, Jung JH, Kim LH, Shin HD

  • KMID: 1097254
  • Exp Mol Med.
  • 2003 Apr;35(2):76-82.
Interleukin 6 (IL6) plays an essential role in the regulation of immune response to chronic disease. In this study, the three known single nucleotide polymorphisms (SNPs) in the IL6 promoter...
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Rapid uptake of oxidized ascorbate induces loss of cellular glutathione and oxidative stress in liver slices

Song JH, Simons C, Cao L, Shin SH, Hong M, Chung IM

  • KMID: 1097253
  • Exp Mol Med.
  • 2003 Apr;35(2):67-75.
The observation that ascorbate known to retain pro-oxidant properties induces cell death in a number of immortal cell lines, led us to examine its mechanism and whether it is involved...
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Gold compound auranofin inhibits I kappaB kinase (IKK) by modifying Cys-179 of IKK beta subunit

Jeon KI, Byun MS, Jue DM

  • KMID: 1097252
  • Exp Mol Med.
  • 2003 Apr;35(2):61-66.
Antirheumatic gold compounds have been shown to inhibit NF-kB activation by blocking IkB kinase (IKK) activity. To examine the possible inhibitory mechanism of gold compounds, we expressed wild type and...
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