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Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner

Lee SM, Park MS

  • KMID: 931883
  • Exp Mol Med.
  • 2002 Sep;34(4):313-317.
Trinucleotide repeat (TNR) instability can cause a variety of human genetic diseases including myotonic dystrophy and Huntington's disease. Recent genetic data show that instability of the CAG/CTG repeat DNA...
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Vibrio vulnificus cytolysin induces hyperadhesiveness of pulmonary endothelial cells for neutrophils through endothelial P-selectin: a mechanism for pulmonary damage by Vibrio vulnificus cytolysin

Kim BS, Kim JS

  • KMID: 931882
  • Exp Mol Med.
  • 2002 Sep;34(4):308-312.
Vibrio vulnificus cytolysin forms transmembrane pores that are permeable to calcium ions in pulmonary endothelial cells, and has been suggested as an important virulence factor that sequestrate neutrophils primarily...
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Catheter-based adenovirus-mediated local intravascular gene delivery of a soluble TGF-beta type II receptor using an Infiltrator in porcine coronary arteries: efficacy and complications

Chung IM, Ueno H, Kim Pak YM, Kim JW, Choi DH, Shin GJ, Yang WI, Jang YS

  • KMID: 931881
  • Exp Mol Med.
  • 2002 Sep;34(4):299-307.
Enhanced extracellular matrix (ECM) accumulation is an important finding in human restenotic arterial neointima after angioplasty. Transforming growth factor b1(TGF-beta1) is known to regulate the synthesis and turnover of...
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Evaluation of a Apo-1/Fas promoter polymorphism in Korean stroke patients

Seo JC, Han SW, Yin CS, Koh HK, Kim CH, Kim EH, Leem KH, Lee HS, Park HJ, Kim SA, Choe BK, Lee HJ, Yim SV, Kim CJ, Chung JH

  • KMID: 931880
  • Exp Mol Med.
  • 2002 Sep;34(4):294-298.
Apoptosis has been implicated in the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. Apo-1/Fas gene is one of the mediators of apoptosis in stroke. MvaI polymorphism...
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Intracellular trafficking and metabolic turnover of yeast prepro-alpha-factor-SRIF precursors in GH3 cells

Lee MA, Cheong KH, Shields D, Park SD, Hong SH

  • KMID: 931879
  • Exp Mol Med.
  • 2002 Sep;34(4):285-293.
Chimeric genes coding for prepro region of yeast alpha-factor and anglerfish SRIF were expressed in rat GH3 cells to determine whether yeast signals could regulate hormone processing in mammalian...
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Improved expression by cytomegalovirus promoter/enhancer and behavior of vascular endothelial growth factor gene after myocardial injection of naked DNA

Jeong JO, Byun JH, Jeon ES, Gwon HC, Lim YS, Park JW, Yeo SJ, Lee YJ, Kim SY, Kim DK

  • KMID: 931878
  • Exp Mol Med.
  • 2002 Sep;34(4):278-284.
Direct injection of the vascular endothelial growth factor (VEGF) gene plasmid DNA into the myocardium was shown to induce development of new blood vessels to increase the circulation in...
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Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death

Yoo YD, Chung YM, Park JK, Ahn CM, Kim SK, Kim HJ

  • KMID: 931877
  • Exp Mol Med.
  • 2002 Sep;34(4):273-277.
Peroxiredoxin II (Prx II) is known not only to protect cells from oxidative damage caused by hydrogen peroxide (H2O2), but also to endow cancer cells with resistance to both...
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Optimal salt concentration of vehicle for plasmid DNA enhances gene transfer mediated by electroporation

Lee MJ, Cho SS, Jang HS, Lim YS, You JR, Park JW, Suh HR, Kim JA, Park JS, Kim DK

  • KMID: 931876
  • Exp Mol Med.
  • 2002 Sep;34(4):265-272.
In vivo electroporation has emerged as a leading technology for developing nonviral gene therapies, and the various technical parameters governing electroporation efficiency have been optimized by both theoretical and...
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The DPE, a core promoter element for transcription by RNA polymerase II

Kadonaga J

  • KMID: 931875
  • Exp Mol Med.
  • 2002 Sep;34(4):259-264.
The core promoter is an important yet often overlooked component in the regulation of transcription by RNA polymerase II. In fact, the core promoter is the ultimate target of...
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