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Effects of Val34Leu and Val35Leu polymorphism on the enzyme activity of the coagulation factor XIII-A

Lee IH, Chung SI, Lee SY

  • KMID: 755212
  • Exp Mol Med.
  • 2002 Nov;34(5):385-390.
Change in fibrin stabilizing activity of factor XIII A subunit (FXIII-A) caused by a specific mutation, Val34Leu, is recently implicated to incidences of pathophysiology of thrombosis. In an effort to...
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C/EBP binding activity to site F of the rat GLUT2 glucose transporter gene promoter is attenuated by c-Jun in vitro

Kim JW, Ahn YH

  • KMID: 755211
  • Exp Mol Med.
  • 2002 Nov;34(5):379-384.
The expression of the GLUT2 glucose transporter gene in liver is suppressed in cultured hepatoma cell lines and primary cultured hepatocytes. Earlier report showed that CCAAT/enhancer binding protein (C/EBP) regulates...
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Proteomic analysis of the cellular proteins induced by adaptive concentrations of hydrogen peroxide in human U937 cells

Seong JK, Kim DK, Choi KH, Oh SH, Kim KS, Lee SS, Um HD

  • KMID: 755210
  • Exp Mol Med.
  • 2002 Nov;34(5):374-378.
When cells are first exposed to low levels of oxidative stress, they develop a resistance to a subsequent challenge of the same stress, even at higher levels. Although some protein(s)...
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Inhibition of BETA2/NeuroD by Id2

Ghil SH, Jeon YJ, Suh-Kim H

  • KMID: 755209
  • Exp Mol Med.
  • 2002 Nov;34(5):367-373.
Id (Inhibitor of Differentiation) proteins belong to a family of transcriptional modulators that are characterized by a helix loop helix (HLH) region but lack the basic amino acid domain. Id...
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Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver

Hong SH, Lee GD, Chung JY, Cho KS, Park SH, Kim IH, Jeong JS

  • KMID: 755208
  • Exp Mol Med.
  • 2002 Nov;34(5):361-366.
Repetitive low dose thioacetamide (TA) treatment of hepatocytes was found to induce cells in G2 arrest. In the present study, an attempt was made to investigate alterations in expression of...
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Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes

Yang JY, Koo BS, Kang MK, Rho HW, Sohn HS, Jhee EC, Park JW

  • KMID: 755207
  • Exp Mol Med.
  • 2002 Nov;34(5):353-360.
The present study was undertaken to explore whether retinoids, which are known to have immunomodulatory actions, could attenuate tumor necrosis factor-alpha (TNF)-stimulated inducible nitric oxide synthase (iNOS) expression in 3T3-L1...
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Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones

Woo KM, Choi Y, Ko SH, Ko JS, Oh KO, Kim KK

  • KMID: 755206
  • Exp Mol Med.
  • 2002 Nov;34(5):347-352.
Osteoprotegerin (OPG), a member of the tumor necrosis factor receptor superfamily, is known to inhibit osteoclastogenesis by acting as a soluble decoy receptor for the receptor activator of NF-kB ligand...
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Macrophage colony-stimulating factor promotes the survival of osteoclast precursors by up-regulating Bcl-XL

Woo KM, Kim HM, Ko JS

  • KMID: 755205
  • Exp Mol Med.
  • 2002 Nov;34(5):340-346.
Macrophage colony-stimulating factor (M-CSF) is known as one of the factors essential for osteoclast development. In the present study, we examined effects of M-CSF on the apoptotic pathway of osteoclast...
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Dual effect of oxidative stress on NF-kappaB activation in HeLa cells

Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM

  • KMID: 755204
  • Exp Mol Med.
  • 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB...
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Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence

Suh D, Oh YK, Ahn BC, Hur MW, Kim HJ, Lee MH, Joo HS, Auh CK

  • KMID: 755203
  • Exp Mol Med.
  • 2002 Nov;34(5):326-331.
Telomeres are the ends of the linear chromosomes of eukaryotes and consist of tandem GT-rich repeats in telomere sequence i.e. 500-3000 repeats of 5'-TTAGGG-3' in human somatic cells, which are...
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Prevention of liver cancer: basic and clinical aspects

Moriwaki H

  • KMID: 755202
  • Exp Mol Med.
  • 2002 Nov;34(5):319-325.
Cancer prevention is a challenging project both in the basic and clinical medicine. In particular, prevention of liver cancer is the most urgent task in countries where the incidence of...
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