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Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells

Shin KS, Shin EY, Lee CS, Quan SH, Woo KN, Soung NK, Kwak SJ, Kim SR, Kim EG

  • KMID: 1081468
  • Exp Mol Med.
  • 2002 May;34(2):172-176.
p21-activated kinase (PAK) targeting to the plasma membrane is essential for PC12 cell neurite outgrowth. Phospholipase C-gamma1 (PLC-gamma1) can mediate the PAK translocation in response to growth factors, since PLC-gamma1...
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Induction of Bis, a Bcl-2-binding protein, in reactive astrocytes of the rat hippocampus following kainic acid-induced seizure

Lee MY, Kim SY, Choi JS, Choi YS, Jeon MH, Lee JH, Kim IK, Lee JH

  • KMID: 1081467
  • Exp Mol Med.
  • 2002 May;34(2):167-171.
The expression of Bis (also called Bag-3), a Bcl-2-binding protein, was investigated in the rat kainic acid (KA) model of temporal lobe epilepsy. Western blot analysis showed a significant increase...
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HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing

Cho CW, Poo H, Cho YS, Cho MC, Lee KA, Lee SJ, Park SN, Kim IK, Jung YK, Choe YK, Yeom YI, Choe IS, Yoon DY

  • KMID: 1081466
  • Exp Mol Med.
  • 2002 May;34(2):159-166.
Cervical cancer is known to be highly associated with viral oncogene E6 and E7 of human papilloma virus. Down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied....
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Quantitative measurement of serum allergen-specific IgE on protein chip

Kim TE, Park SW, Cho NY, Choi SY, Yong TS, Nahm BH, Lee S, Noh G

  • KMID: 1081465
  • Exp Mol Med.
  • 2002 May;34(2):152-158.
Type I allergy is an immunoglobulin E (IgE)-mediated hypersensitivity disease inflicting more than quarter of the world population. In order to identify allergen sources, skin provocation test and IgE serology...
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Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression

Kim YH, Kim GS, Baek JH

  • KMID: 1081464
  • Exp Mol Med.
  • 2002 May;34(2):145-151.
The mechanism of inhibitory action of bisphosphonates on bone resorption is not fully elucidated. Osteoclast formation and activity are regulated by osteoblast-derived factors such as the osteoclast differentiating factor, receptor...
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Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro

Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK

  • KMID: 1081463
  • Exp Mol Med.
  • 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and...
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Differential expression of two stress-inducible hsp70 genes by various stressors

Lee JS, Seo JS

  • KMID: 1081462
  • Exp Mol Med.
  • 2002 May;34(2):131-136.
Inducible HSP70s encoded by two almost identical hsp70 genes, known as hsp70.1 and hsp70.3 are located in a tandem array on mouse chromosome 17. Duplication of this gene has been...
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Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes

Kim YH, Shin MJ

  • KMID: 1081461
  • Exp Mol Med.
  • 2002 May;34(2):123-130.
Membrane-associated cytotoxicity induced by hydrophobic bile salts is a major contributing factor leading to liver diseases. Administration of ursodeoxycholate reduces serum liver enzymes in chronic liver diseases but the nature...
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Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin

Shin EC, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong SS, Park JH

  • KMID: 1081460
  • Exp Mol Med.
  • 2002 May;34(2):114-122.
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors,...
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The effect of telomerase expression on the escape from M2 crisis in virus-transformed human retinal pigment epithelial cells

Park JK, Kim BH, Han YS, Park IK

  • KMID: 1081459
  • Exp Mol Med.
  • 2002 May;34(2):107-113.
Transformation with viral oncogene extends the lifespan of normal cells beyond replicative senescence called M1, but most of them eventually succumb to second crisis called M2 when telomeres become critically...
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Antioxidant activity of extracts from Euryale ferox seed

Lee SE, Ju EM, Kim JH

  • KMID: 1081458
  • Exp Mol Med.
  • 2002 May;34(2):100-106.
Euryale ferox has been widely used in traditional oriental medicine to treat a variety of illness. However, very little is known about the cellular actions by which this plant mediates...
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Effects of estrogen receptor and estrogen on the chromatin structure in estrogen receptor stable transfectants

Lee YJ, Lim WC, Jin YH, Lee SK

  • KMID: 1081457
  • Exp Mol Med.
  • 2002 May;34(2):95-99.
The estrogen receptor (ER), a member of the nuclear hormone receptor superfamily recruits coactivators that modify local chromatin structure. Here we investigated the effect of the estrogen receptor and estrogen...
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