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Improved immunodetection of human papillomavirus E7

Jeon JH, Cho SY, Kim CW, Shin DM, Kwon JC, Choi KH, Kim IG

  • KMID: 1121105
  • Exp Mol Med.
  • 2002 Dec;34(6):496-499.
Human papillomavirus E7 (HPV E7) is a viral oncoprotein that plays an important role in cervical carcinogenesis through binding with retinoblastoma protein (Rb). Inactivation of Rb by E7 is...
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Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as well as in vitro

Kang KR, Kim JS, Chung SI, Park MH, Kim YW, Lim DK, Lee SY

  • KMID: 1121104
  • Exp Mol Med.
  • 2002 Dec;34(6):489-495.
Deoxyhypusine synthase catalyzes the first step in the posttranslational synthesis of an unusual amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF-5A) precursor protein. We earlier observed...
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Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism

Yoon MC, Jeong SH, Nicol CJ, Lee HH, Han MY, Kim JJ, Seo YJ, Ryu CY, Oh GT

  • KMID: 1121103
  • Exp Mol Med.
  • 2002 Dec;34(6):481-488.
To determine whether the PPARalpha agonist fenofibrate regulates obesity and lipid metabolism with sexual dimorphism, we examined the effects of fenofibrate on body weight, white adipose tissue (WAT) mass,...
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Interaction between chicken protein tyrosine phosphatase 1 (CPTP1)-like rat protein phosphatase 1 (PTP1) and p60v-src in v-src-transformed Rat-1 fibroblasts

Jung EJ, Kim CW

  • KMID: 1121102
  • Exp Mol Med.
  • 2002 Dec;34(6):476-480.
CPTP1 is a nontransmembrane chicken protein tyrosine phosphatase having 92% sequence homology to the corresponding 321 amino acids of human protein tyrosine phosphatase 1B (HPTP1B). Using anti-CPTP1 antibody, we...
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Overexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells

Kim SY, Ghil SH, Kim SS, Myeong HH, Lee YD, Suh-Kim HY

  • KMID: 1121101
  • Exp Mol Med.
  • 2002 Dec;34(6):469-475.
Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expressed in neuronal precursors in the developing nervous system. The function of Ngn1 in neurogenesis has been shown in various...
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Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappa B activation

Lee KY, Park JS, Jee YK, Rosen GD

  • KMID: 1121100
  • Exp Mol Med.
  • 2002 Dec;34(6):462-468.
TNF-related apoptosis-inducing ligand (TRAIL/Apo- 2L), a newly identified member of the TNF family promotes apoptosis by binding to the transmembrane receptors (TRAIL-R1/DR4 and TRAIL-R2/ DR5). TRAIL known to activate...
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Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells

Chung HK, Lee IK, Kang HK, Suh JM, Kim H, Park KC, Kim DW, Kim YK, Ro HK, Shong MH

  • KMID: 1121099
  • Exp Mol Med.
  • 2002 Dec;34(6):451-461.
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where...
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Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts

Shin SY, Yoon SC, Kim YH, Kim YS, Lee YH

  • KMID: 1121098
  • Exp Mol Med.
  • 2002 Dec;34(6):444-450.
Phospholipase Cgamma1 (PLCgamma1) plays an important role in controlling cellular proliferation and differentiation. PLCgamma1 is overexpressed in some tumors, and its overexpression induces solid tumors in nude mice. However,...
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Phosphorylation of 46-kappa Da protein of synaptic vesicle membranes is stimulated by GTP and Ca2+/calmodulin

Kim AR, Choi WH, Lee SR, Kim JS, Jeon CY, Kim JI, Kim JB, Lee JY, Kim EG, Park JB

  • KMID: 1121097
  • Exp Mol Med.
  • 2002 Dec;34(6):434-443.
The release of neurotransmitter is regulated in the processes of membrane docking and membrane fusion between synaptic vesicles and presynaptic plasma membranes. Synaptic vesicles contain a diverse set of...
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Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis

Choi KY, Lee SW, Park MH, Bae YC, Shin HI, Nam SH, Kim YJ, Kim HJ, Ryoo HM

  • KMID: 1121096
  • Exp Mol Med.
  • 2002 Dec;34(6):426-433.
Skeletogenesis occurs through either intramembranous or endochondral ossification. In addition, some parts of the skeletal components maintain their cartilaginous characteristics throughout life without mineralization. Runx2 is known to be...
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Effects of glutamate on dehydroascorbate uptake and Its enhanced vulnerability to the peroxidation in cerebral cortical slices

Song JH, Shin SH, Chung IM

  • KMID: 1121095
  • Exp Mol Med.
  • 2002 Dec;34(6):419-425.
Pro-oxidant properties of ascorbate have been studied with uses of brain tissues and neuronal cells. Here we address potential mechanism of ascorbate coupling with glutamate to generate oxidative stress,...
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Characterization and epitope mapping of two monoclonal antibodies against human CD99

Gil MC, Lee MH, Seo JI, Choi YL, Kim MK, Jung KC, Park SH, Kim TJ

  • KMID: 1121094
  • Exp Mol Med.
  • 2002 Dec;34(6):411-418.
CD99 plays an critical role in the diapedesis of monocytes, T cell differentiation, and the transport of MHC molecules. Engagement of CD99 by agonistic monoclonal antibodies has been reported...
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Neural cell adhesion molecule (NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type

Shin MH, Lee EG, Lee SH, Lee YS, Son H

  • KMID: 1121093
  • Exp Mol Med.
  • 2002 Dec;34(6):401-410.
Rat hippocampal precursor cells isolated from hippocampi of embryonic day 16.5 (E16.5) rat embryos were found to proliferate in the presence of basic fibroblast growth factor. Addition of soluble...
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Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: The potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis

Choi EY, Kim DS, Hong BK, Kwon HM, Song YG, Byun KH, Park HY, Whang KC, Kim HS

  • KMID: 1121092
  • Exp Mol Med.
  • 2002 Dec;34(6):391-400.
Chlamydia pneumoniae infection implicated as an important etiologic factor of atherosclerosis, especially in coronary artery disease (CAD), was found in vitro to be associated with the induction of matrix...
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