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Monitoring transfected cells without selection agents by using the dual-cassette expression EGFP vectors

Kang SG, Lee EK, Schaus S, Henderson

  • KMID: 938883
  • Exp Mol Med.
  • 2001 Sep;33(3):174-178.
Conventional methods of selecting gene transfected cells by toxic agents may yield ambiguous results. It is difficult to determine whether cell death is due to selection agents or gene transfection,...
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Cloning of BNIP3h, a member of proapoptotic BNIP3 family genes

Farooq M, Kim YH, Im SU, Chung EJ, Hwang SY, Sohn MY, Kim MK, Kim JC

  • KMID: 938882
  • Exp Mol Med.
  • 2001 Sep;33(3):169-173.
Apoptosis is regulated by interaction of antiapoptotic Bcl-2 family proteins with various proapoptotic proteins, several of which are also members of the Bcl-2 family. BNIP3 (formerly NIP3) is a proapoptotic...
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Immunohistochemical localization of eight phospholipase C isozymes in pancreatic islets of the mouse

Kim SS, Jun KS, Jeong MJ, Ryu SH, Suh PG, Shin HS

  • KMID: 938881
  • Exp Mol Med.
  • 2001 Sep;33(3):164-168.
The possible involvement of phospholipase C (PLC) in the regulation of insulin secretion is not clearly understood and neither its isozymes expressed nor cellular localization in the pancreatic islets is...
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Protein kinase C modulates telomerase activity in human cervical cancer cells

Kim YW, Hur SY, Kim TE, Lee JM, Namkoong S, Ki IK, Kim JW

  • KMID: 938880
  • Exp Mol Med.
  • 2001 Sep;33(3):156-163.
Telomerase, a ribonucleoprotein reverse transcriptase that extends telomeres of eukaryotic chromosomes is repressed in normal somatic cells but is activated during development and neoplasia. The regulation mechanism of telomerase activity...
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ATP-induced focal adhesion kinase activity is negatively modulated by phospholipase D2 in PC12 cells

Bae YS, Ryu SH

  • KMID: 938879
  • Exp Mol Med.
  • 2001 Sep;33(3):150-155.
Extracellular ATP has been known to modulate various cellular responses including mitogenesis, secretion and morphogenic activity in neuronal cells. In the ATP-induced morphogenic activity, focal adhesion kinase(s) such as Fak...
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Development of a packaging cell line for propagation of replication-deficient adenovirus vector

Kim JS, Lee SH, Cho YS, Park KS, Kim YH, Lee JH

  • KMID: 938878
  • Exp Mol Med.
  • 2001 Sep;33(3):145-149.
A human embryonic kidney cell line 293 is widely used for adenovirus production and propagation. With this cell line, however, replication-competent virus (RCV) is frequently generated, especially during large-scale production...
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Alterations of HLA class I and II antigen expression in preinvasive, invasive and metastatic cervical cancers

Ryu KS, Lee YS, Kim BK, Park YG, Kim YW, Hur SY, Kim TE, Kim IK, Kim JW

  • KMID: 938877
  • Exp Mol Med.
  • 2001 Sep;33(3):136-144.
HLA expression is altered in a large variety of human cancers. We performed immunohistochemical staining on tissues from normal, preinvasive, invasive and metastatic cervical cancer tissues using anti-HLA class I...
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Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells

Jung GD, Yang JY, Song ES, Park JW

  • KMID: 938876
  • Exp Mol Med.
  • 2001 Sep;33(3):131-135.
Glycyrrhizin (GR), triterpenoid saponin composed of one glycyrrhetinic acid (GA) and two glucuronic acids, is a main constituent of the hydrophilic fraction of licorice (Glycyrrhiza glabra) extracts and is known...
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Characterization of aberrant FHIT transcripts in gastric adenocarcinomas

Lee SH, Kim CJ, Park HK, Koh JW, Cho MH, Baek MJ, Lee MS

  • KMID: 938875
  • Exp Mol Med.
  • 2001 Sep;33(3):124-130.
Aberrant transcripts of FHIT (fragile histidine triad) have been reported in several types of primary tumors and cell lines, including gastric carcinoma. The role of these aberrant transcripts in tumorigenesis...
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Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents

Kim SA, Kang JH, Cho IH, Bae SW, Hong KJ

  • KMID: 938874
  • Exp Mol Med.
  • 2001 Sep;33(3):117-123.
Thrombospondin-1 (TSP-1), a multifunctional protein that is able to function as a negative regulator of solid tumor progression and angiogenesis, is normally present at a very low level but rapidly...
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Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas

Nam DH, Song SY, Park KS, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH

  • KMID: 938873
  • Exp Mol Med.
  • 2001 Sep;33(3):111-116.
Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11...
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