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Regulation of GTP-binding state in RalA through Ca2+ and calmodulin

Park JB

  • KMID: 755118
  • Exp Mol Med.
  • 2001 Mar;33(1):54-58.
RalA GTPase, a member of Ras superfamily proteins, shows alternative forms between the active GTP-binding and the inactive GDP-binding states. Ral-specific guanine nucleotide exchange factor such as RalGDS interacts with...
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Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin)

Song SU, Boyce FM

  • KMID: 755117
  • Exp Mol Med.
  • 2001 Mar;33(1):46-53.
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been evaluated as a vector for gene delivery to human tumor cells. A human osteogenic sarcoma cell line, Saos-2,...
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Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha

Jang IS, Juhnn YS

  • KMID: 755116
  • Exp Mol Med.
  • 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein...
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Effect of metal ions on the stability of metallothionein in the degradation by cellular fractions in vitro

Hahn SH, Yoo OJ, Gahl WA

  • KMID: 755115
  • Exp Mol Med.
  • 2001 Mar;33(1):32-36.
Metallothioneins (MT), small molecular weight metal binding proteins are known to play an important protective role against heavy metal toxicity, either as antioxidants or pre-oxidants. However, the mode of metabolic...
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F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients

Jung YY, Ha HI, Jung SH, Lee MG, Lee HW, Yoon JH, Choi JW, Yeh BI

  • KMID: 755114
  • Exp Mol Med.
  • 2001 Mar;33(1):29-31.
Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between...
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Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation

Kim YH, Joo I

  • KMID: 755113
  • Exp Mol Med.
  • 2001 Mar;33(1):23-28.
Methylation catalyzed by methyltransferases is a major metabolic pathway for an inactivation of some catecholamines, niacinamide as well as aliphatic sulfhydryl drugs and toxic hydrogen sulfides. To investigate the effects...
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L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia

Kumosani T

  • KMID: 755112
  • Exp Mol Med.
  • 2001 Mar;33(1):20-22.
Ergothioneine is widely distributed in biological systems, particularly in red blood cells of animals. However, it's functional role in human body is not well understood. In order to investigate the...
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Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells

Bae CD, Juhnn YS, Park JB

  • KMID: 755111
  • Exp Mol Med.
  • 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the...
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Detection of circulating tumor cells in patients with gastrointestinal tract cancer using RT-PCR and its clinical implications

Noh YH, Kim JA, Lim GR, Ro YT, Koo JH, Lee YS, Han DS, Park HK, Ahn MJ

  • KMID: 755110
  • Exp Mol Med.
  • 2001 Mar;33(1):8-14.
To investigate the relationship between the presence of circulating tumor cells in different stages of gastrointestinal tract cancer and the subsequent relapse or distant metastasis, circulating levels of CEA mRNA...
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Recent progress in lysosomal alpha-mannosidase and its deficiency

Sun H, Wolfe JH

  • KMID: 755109
  • Exp Mol Med.
  • 2001 Mar;33(1):1-7.
Lysosomal alpha-mannosidase (EC 3.2.1.24) is a major exoglycosidase in the glycoprotein degradation pathway. A deficiency of this enzyme causes the lysosomal storage disease, alpha-mannosidosis, which has been described in humans,...
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