- Recent progress in lysosomal alpha-mannosidase and its deficiency
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Sun H, Wolfe JH
- KMID: 755109
- Exp Mol Med.
- 2001 Mar;33(1):1-7.
Lysosomal alpha-mannosidase (EC 3.2.1.24) is a major exoglycosidase in the glycoprotein degradation pathway. A deficiency of this enzyme causes the lysosomal storage disease, alpha-mannosidosis, which has been described in humans,... -
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- Effect of metal ions on the stability of metallothionein in the degradation by cellular fractions in vitro
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Hahn SH, Yoo OJ, Gahl WA
- KMID: 755115
- Exp Mol Med.
- 2001 Mar;33(1):32-36.
Metallothioneins (MT), small molecular weight metal binding proteins are known to play an important protective role against heavy metal toxicity, either as antioxidants or pre-oxidants. However, the mode of metabolic... -
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- Post-transcriptional control of c-erb B-2 overexpression in stomach cancer cells
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Bae CD, Juhnn YS, Park JB
- KMID: 755111
- Exp Mol Med.
- 2001 Mar;33(1):15-19.
The growth factor receptor oncogene, c-erb B-2, is frequently overexpressed in the adenocarcinomas of breast, ovary, lung and stomach. Although the mechanism of erb B-2 overexpression is thought as the... -
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- L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia
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Kumosani T
- KMID: 755112
- Exp Mol Med.
- 2001 Mar;33(1):20-22.
Ergothioneine is widely distributed in biological systems, particularly in red blood cells of animals. However, it's functional role in human body is not well understood. In order to investigate the... -
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- F508 amino acid deletion mutation of CFTR gene in Korean lung cancer patients
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Jung YY, Ha HI, Jung SH, Lee MG, Lee HW, Yoon JH, Choi JW, Yeh BI
- KMID: 755114
- Exp Mol Med.
- 2001 Mar;33(1):29-31.
Mutations of the transmembrane conductance regulator (CFTR) gene in cystic fibrosis lead to dysfunction of the lung, pancreas, and sweat glands, etc. To investigate the possibility of the relationship between... -
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- Regulation of GTP-binding state in RalA through Ca2+ and calmodulin
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Park JB
- KMID: 755118
- Exp Mol Med.
- 2001 Mar;33(1):54-58.
RalA GTPase, a member of Ras superfamily proteins, shows alternative forms between the active GTP-binding and the inactive GDP-binding states. Ral-specific guanine nucleotide exchange factor such as RalGDS interacts with... -
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- Combination treatment for osteosarcoma with baculoviral vector mediated gene therapy (p53) and chemotherapy (adriamycin)
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Song SU, Boyce FM
- KMID: 755117
- Exp Mol Med.
- 2001 Mar;33(1):46-53.
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) has been evaluated as a vector for gene delivery to human tumor cells. A human osteogenic sarcoma cell line, Saos-2,... -
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- Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation
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Kim YH, Joo I
- KMID: 755113
- Exp Mol Med.
- 2001 Mar;33(1):23-28.
Methylation catalyzed by methyltransferases is a major metabolic pathway for an inactivation of some catecholamines, niacinamide as well as aliphatic sulfhydryl drugs and toxic hydrogen sulfides. To investigate the effects... -
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- Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha
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Jang IS, Juhnn YS
- KMID: 755116
- Exp Mol Med.
- 2001 Mar;33(1):37-45.
Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein... -
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- Detection of circulating tumor cells in patients with gastrointestinal tract cancer using RT-PCR and its clinical implications
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Noh YH, Kim JA, Lim GR, Ro YT, Koo JH, Lee YS, Han DS, Park HK, Ahn MJ
- KMID: 755110
- Exp Mol Med.
- 2001 Mar;33(1):8-14.
To investigate the relationship between the presence of circulating tumor cells in different stages of gastrointestinal tract cancer and the subsequent relapse or distant metastasis, circulating levels of CEA mRNA... -
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