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Homozygous VN (677C to T) and d/D (2756G to A) variants in the methylenetetrahydrofolate and methionine synthase genes in a case of hyperhomocysteinemia with stroke at young age

Song KS, Song JW, Choi JR, Kim HK, Shin JS, Kim JH

  • KMID: 1085748
  • Exp Mol Med.
  • 2001 Jun;33(2):106-109.
Hyperhomocysteinemia is known to be associated with an increased risk of myocardial infarction, stroke, peripheral arterial disease, and venous thrombosis. Gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS)...
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An enzymatic method for the detection of human serum albumin

Javed MU, Waqar SN

  • KMID: 1085747
  • Exp Mol Med.
  • 2001 Jun;33(2):103-105.
Albumin is the most abundant protein in human serum. A dye-binding method is commonly used in clinical laboratories for its estimation using different types of dyes. However, all these dye...
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Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang YS, Cho SY, Kim HS

  • KMID: 1085746
  • Exp Mol Med.
  • 2001 Jun;33(2):95-102.
Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass. Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent intracellular...
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Cell-free expression and functional reconstitution of CALM in clathrin assembly

Kim JA, Kim HL

  • KMID: 1085745
  • Exp Mol Med.
  • 2001 Jun;33(2):89-94.
Clathrin-mediated vesicle formation is an essential step in the intracellular trafficking of the protein and lipid. Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicles...
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A novel method using edge detection for signal extraction from cDNA microarray image analysis

Kim JH, Kim HY, Lee YS

  • KMID: 1085744
  • Exp Mol Med.
  • 2001 Jun;33(2):83-88.
Gene expression analyses by probes of hybridization from mRNA to cDNA targets arrayed on membranes or activated glass surfaces have revolutionized the way of profiling mega level gene expression. The...
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Cloning and characterization of 5'-upstream region of human phospholipase C-beta2 gene

Yun ES, Lee SJ, Kim MJ, Ryu SH, Suh PG

  • KMID: 1085743
  • Exp Mol Med.
  • 2001 Jun;33(2):76-82.
5'-upstream region of the phospholipase C-beta2 gene, 810 bp, was cloned and characterized. S1 nuclease mapping and primer extension analyses revealed that a single transcriptional start site locates at 284...
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Production and characterization of monoclonal antibodies against amphiphysins

Jin YL, Kim KY, Soung NK, Shin EY, Kim EG, Kim SR

  • KMID: 1085742
  • Exp Mol Med.
  • 2001 Jun;33(2):69-75.
Amphiphysin I and II, proteins enriched in nerve terminals, form heterodimers and interact with dynamin and synaptojanin through their Src homology 3 (SH3) domain. In order to study the expression...
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The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation

Park BH, Park JW

  • KMID: 1085741
  • Exp Mol Med.
  • 2001 Jun;33(2):64-68.
This study was undertaken to investigate the preventive mechanism of Amomum xanthoides extract against the development of alloxan-induced diabetics of mice. Pretreatment of mice with A. xanthoides extract via intraperitoneum...
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HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene

Cha JY, Kim HI, Im SS, Li TZ, Ahn YH

  • KMID: 1085740
  • Exp Mol Med.
  • 2001 Jun;33(2):59-63.
A possible role of hepatocyte nuclear factor 1 (HNF1) or HNF3, a predominant trans-acting factors of hepatic or pancreatic beta-cells, was examined on the tissue specific interdependent expression of glucokinase...
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