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D60-sensitive tyrosine phosphorylation is involved in Fas-mediated phospholipase D activation

Kim JG, Shin IC, Lee KS, Han JS

  • KMID: 1457546
  • Exp Mol Med.
  • 2001 Dec;33(4):303-309.
Both Fas and PMA can activate phospholipase D via activation of protein kinase Cbeta in A20 cells. Phospholipase D activity was increased 4 fold in the presence of Fas and...
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Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes

Min BH, Kim HJ, Lim HJ, Park CS, Park SR

  • KMID: 1457545
  • Exp Mol Med.
  • 2001 Dec;33(4):299-302.
Nitric oxide (NO) has been considered as an important mediator in inflammatory phases and in loss of cartilage. In inflammatory arthritis, NO levels are correlated with disease activity and articular...
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Immortalization of human embryonic fibroblasts by overexpression of c-myc and simian virus 40 large T antigen

Kim HS, Shin JY, Yun JY, Ahn DK, Lee JY

  • KMID: 1457544
  • Exp Mol Med.
  • 2001 Dec;33(4):293-298.
SV40 large T antigen, a viral oncoprotein, is known to immortalize human diploid fibroblast by soaking up cellular RB and p53, but its frequency is extremely low. Additional genetic alteration...
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Activation of caspase-8 in 3-deazaadenosine-induced apoptosis of U-937 cells occurs downstream of caspase-3 and caspase-9 without Fas receptor-ligand interaction

Chae YJ, Kim HS, Rhim HS, Kim BE, Jeong SW, Kim IK

  • KMID: 1457543
  • Exp Mol Med.
  • 2001 Dec;33(4):284-292.
3-Deazaadenosine (DZA), a cellular methylation blocker was reported to induce the caspase-3-like activities-dependent apoptosis in U-937 cells. In this study, we analyzed the activation pathway of the caspase cascade involved...
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c-Jun N-terminal kinase is involved in motility of endothelial cell

Shin EY, Kim SY, Kim EG

  • KMID: 1457542
  • Exp Mol Med.
  • 2001 Dec;33(4):276-283.
Cell motility is essential for a wide range of cellular activities including anigogenesis as well as metastasis of tumor cells. Ras has been implicated in cell migration and invasion, and...
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Transcriptional repression of type I procollagen genes during adipocyte differentiation

Yi TG, Choi HM, Park RW, Sohn KY, Kim IS

  • KMID: 1457541
  • Exp Mol Med.
  • 2001 Dec;33(4):269-275.
Adipocyte differentiation is a very complex process in which whole-cell changes are accompanied. Among them, type I procollagen gene has been shown to specifically decrease during adipocyte differentiation; however, little...
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Free radical scavenging and antioxidant enzyme fortifying activities of extracts from Smilax china root

Lee SE, Ju EM, Kim JH

  • KMID: 1457540
  • Exp Mol Med.
  • 2001 Dec;33(4):263-268.
The extract from Smilax china root has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic acitivities. In this study, a possible presence of antioxidant activity of...
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The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells

Kim YD, Bae YS, Park JC, Suh PG, Ryu SH

  • KMID: 1457539
  • Exp Mol Med.
  • 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of...
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Point mutation and polymorphism in Duchenne/Becker muscular dystrophy (D/BMD) patients

Chaturvedi LS, Mukherjee , Srivastava S, Mittal RD, Mittal B

  • KMID: 1457538
  • Exp Mol Med.
  • 2001 Dec;33(4):251-256.
Duchenne and Becker muscular dystrophies (D/BMD) are caused by mutations in the dystrophin gene. Two-thirds of patients have large intragenic deletions or duplications and the remaining one-third have point mutations,...
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Cleavage of purified neuronal clathrin assembly protein (CALM) by caspase 3 and calpain

Kim JA, Kim HL

  • KMID: 1457537
  • Exp Mol Med.
  • 2001 Dec;33(4):245-250.
The most efficient means of protein internalization from the membrane are through clathrin-coated pits, which concentrate protein interactions with the clathrin-associated assembly protein complex AP-2 and internalization signals in the...
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Effects of cations on ceramide-activated protein phosphatase 2A

Galadari S, Hago A, Patel M

  • KMID: 1457536
  • Exp Mol Med.
  • 2001 Dec;33(4):240-244.
Characterization of ceramide-effector(s), which includes protein phosphatase 2A (PP2A) is an important prelude to understanding the molecular basis of sphingolipid-mediated biological effects such as cell growth, differentiation and apoptosis. Recently,...
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Regulation of leptin gene expression by insulin and growth hormone in mouse adipocytes

Lee KN, Jeong IC, Lee SJ, Oh SH, Cho MY

  • KMID: 1457535
  • Exp Mol Med.
  • 2001 Dec;33(4):234-239.
The role of leptin in the control of obesity, insulin resistance and type II diabetes has been reported, however, the regulatory mechanism of leptin in animals affected by hormones is...
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Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.

Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA

  • KMID: 1457534
  • Exp Mol Med.
  • 2001 Dec;33(4):226-233.
Our recent studies have shown that co-activation of Gq and Gi proteins by 5-hydroxytryptamine (5-HT) and adrenaline show synergism in human platelet aggregation. This study was conducted to examine the...
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The proteins of synaptic vesicle membranes are affected during ageing of rat brain

Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB

  • KMID: 1457533
  • Exp Mol Med.
  • 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in...
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p53 gene transfer does not enhance E2F-1-mediated apoptosis in human colon cancer cells

Draus JM, Elliott MJ, Atienza C, Stilwell A, Wong SL, Dong Y, Yang H, McMasters

  • KMID: 1457532
  • Exp Mol Med.
  • 2001 Dec;33(4):209-219.
E2F-1 and p53 are sequence specific transcription factors that are intimately involved in the regulation of the cell cycle. In addition to their role in cell cycle control, both E2F-1...
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Study of ethidium bromide interaction peculiarities with DNA

Vardevanyan PO, Antonyan A, Manukyan G, Karapetyan AT

  • KMID: 1457531
  • Exp Mol Med.
  • 2001 Dec;33(4):205-208.
The helix-coil transition of DNA-ethidium bromide complexes in an interval of ionic strength of 2.0 x 10(-3) M < or = muNa+ < or = 2.0 x 10(-2) M has...
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Effect of serum and hydrogen peroxide on the Ca2+/calmodulin-dependent phosphorylation of eukaryotic elongation factor 2(eEF-2) in Chinese hamster ovary cells

Kang KR, Lee SY

  • KMID: 1457530
  • Exp Mol Med.
  • 2001 Dec;33(4):198-204.
Eukaryotic elongation factor eEF-2 mediates regulatory steps important for the overall regulation of mRNA translation in mammalian cells and is activated by variety of cellular conditions and factors. In this...
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Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases

Patel MS, Korotchkina LG

  • KMID: 1457529
  • Exp Mol Med.
  • 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human...
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Chronic liver injury, TGF-beta, and cancer

Bissell DM

  • KMID: 1457528
  • Exp Mol Med.
  • 2001 Dec;33(4):179-190.
Cells termed myofibroblasts are prominent in the injury response of all epithelial tissues. They exhibit proliferation, migration, production of collagen and other extracellular matrix (ECM) molecules, and contraction, all for...
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