- Molecular cloning and sequencing of rat Cdc42 GTPase cDNA
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Han JS, Kim JH, Kim JG, Park JB, Noh DY, Lee KH
- KMID: 755074
- Exp Mol Med.
- 2000 Sep;32(3):115-119.
Cdc42 is a member of the Rho family of small GTP-ase and plays an important role in intracellular signaling pathways regulating cell morphology, motility and stimulation of DNA... -
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- Identification of Escherichia coli 8-oxoguanine endonuclease
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Lee YS, Chung MH
- KMID: 755080
- Exp Mol Med.
- 2000 Sep;32(3):155-160.
7,8-Dihydro-8-oxoguanine (oh8Gua) endonuclease is a DNA repair enzyme in Escherichia coli to remove oh8Gua, a promutagenic DNA adduct. Due to the unique mode of enzyme action and substrate specificity, this... -
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- The mechanism of phospholipase C-gamma1 regulation
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Kim MJ, Kim EK, Ryu SH, Suh PG
- KMID: 755072
- Exp Mol Med.
- 2000 Sep;32(3):101-109.
Phospholipase C (PLC)1 hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate the second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 induces a transient increase in intracellular free Ca2+, while... -
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- Molecular assembly of mitogen-activated protein kinase module in ras-transformed NIH3T3 cell line
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Park KS, Kim JA, Chai KJ
- KMID: 755075
- Exp Mol Med.
- 2000 Sep;32(3):120-126.
The ras, is a G-like protein that controls the mitogen-activated protein kinase (MAPK) pathway involved in control and differentiation of cell growth. MAPK is a key component of its... -
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- An improved method for quantitative sugar analysis of glycoproteins
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Kim S, Kim SH, Kim SI, Ha KS, Leem SH
- KMID: 755078
- Exp Mol Med.
- 2000 Sep;32(3):141-145.
Although there are numerous methods available to hydrolyze glycans utilizing strong acids, it all requires lengthy steps to obtain quantitative yield. We have developed a new simple one-step method for... -
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- Effect of short-term ethanol on the proliferative response of Swiss 3T3 cells to mitogenic growth factors
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Yeo EJ, Lim HK, Park SC
- KMID: 755081
- Exp Mol Med.
- 2000 Sep;32(3):161-169.
Both adaptive and deleterious responses of cells to ethanol are likely triggered by short-term interactions of the cells with ethanol. Many studies have demonstrated the direct effect of ethanol... -
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- Molecular characteristics of the inhibition of human neutrophil elastase by nonsteroidal antiinflammatory drugs
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Kang K, Bae SJ, Kim WM, Lee DH, Cho US, Lee MS, Lee MH, Nam SI, Kuettner K, Schwartz D
- KMID: 755079
- Exp Mol Med.
- 2000 Sep;32(3):146-154.
Nonsteroidal antiinflammatory drugs(NSAIDs) are known as clinically effective agents for treatment of inflammatory diseases. Inhibition of cyclooxygenase has been thought to be a major facet of the pharmacological mechanism of... -
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- Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock
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Cho CH, Cho DH, Seo MR, Juhnn YS
- KMID: 755073
- Exp Mol Med.
- 2000 Sep;32(3):110-114.
Electroconvulsive shock (ECS) has been suggested to affect cAMP signaling pathways to exert therapeutic effects. ECS was recently reported to increase the expression of PDE4 isoforms in rat brain,... -
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- Dexamethasone enhances phospholipase D activity in M-1 cells
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Kim WJ, Lee MJ, Park MA, Jung JS, Uhlinger D, Kwak JY
- KMID: 755082
- Exp Mol Med.
- 2000 Sep;32(3):170-177.
Phospholipase D (PLD) is an enzyme involved in signal transduction and widely distributed in mammalian cells. The signal transduction pathways and role for phospholipid metabolism during hormonal response in... -
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- Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells
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Kim SA, Hong KJ
- KMID: 755077
- Exp Mol Med.
- 2000 Sep;32(3):135-140.
Thrombospondin-1 (TSP-1), a multifunctional extracellular matrix protein, inhibits neovascularization and is implicated in the regression of tumor growth and metastasis. We found that the synthesis of TSP-1 in... -
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- Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines
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Hong YS, Ham YA, Choi JH, Kim JG
- KMID: 755076
- Exp Mol Med.
- 2000 Sep;32(3):127-134.
Allyl sulfur compounds play a major role in the chemoprevention against carcinogenesis. The present study compared the antiproliferative effects of diallyl sulfide (DAS), diallyl disulfide (DADS) and garlic... -
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