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Fas-mediated apoptosis and expression of related genes in human malignant hematopoietic cells

Kim KM, Lee KH, Hong YS, Park HY

  • KMID: 755108
  • Exp Mol Med.
  • 2000 Dec;32(4):246-254.
Fas transduces apoptotic signals upon cross-linking with the Fas ligand (FasL), which is experimentally replaced by agonistic anti-Fas monoclonal antibodies (mAb). Of eight human malignant hematopoietic cell lines...
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Analysis of trimethylsilyl derivatization products of phosphatidylethanol by gas chromatography-mass spectrometry

Yon CS, Han JS

  • KMID: 755107
  • Exp Mol Med.
  • 2000 Dec;32(4):243-245.
For the detection of rare phospholipid, phosphatidylethanol (PEt), GC-MS analysis method was adopted for the detection of derivatization products of PEt by N,O-bis (trimethylsilyl) trifluroacetamide (BSTFA). A re-structured...
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Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment

Cho DH, Bae CD, Juhnn YS

  • KMID: 755106
  • Exp Mol Med.
  • 2000 Dec;32(4):235-242.
The terminal differentiation of malignant melanoma cells is known to be induced by activating cAMP signaling pathway with alpha-MSH or cAMP analogues. However, sustained activation of cAMP signaling...
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Y chromosome microdeletions in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome

Lee YH, Kim T, Kim MH, Kim YT, Kim SH

  • KMID: 755105
  • Exp Mol Med.
  • 2000 Dec;32(4):231-234.
The objective of this study was to elucidate the cause of the spermatogenic defect in idiopathic azoospermia and non-mosaic type of Klinefelter syndrome. Genomic DNAs from 9 cases...
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Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure

Jeon SH, Kim YS, Bae CD, Park JB

  • KMID: 755104
  • Exp Mol Med.
  • 2000 Dec;32(4):227-230.
Kainic acid, an analogue of glutamate, causes limbic seizures and induces cell death in the rat brain. We examined the activation of MAPK family kinases; ERKs, JNKs and...
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Purification of clathrin assembly protein from rat liver

Kim HL, Kim JA

  • KMID: 755103
  • Exp Mol Med.
  • 2000 Dec;32(4):222-226.
Recently, the gene encoding clathrin assembly protein of lymphoid myeloid leukemia (CALM), which is homologous to the AP180, was cloned from rat brain, and its expression differential to...
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Association of castration-dependent early induction of c-myc expression with a cell proliferation of the ventral prostate gland in rat

Lim K, Park C, Kim YK, Yun KA, Son MY, Lee YC, Park JI, Lee JH, Sul CK, Lee CS, Park SK, Hwang BD

  • KMID: 755102
  • Exp Mol Med.
  • 2000 Dec;32(4):216-221.
The protooncogene c-myc is known to be associated with both cell proliferation and apoptosis. The possible cellular affects of castration on the ventral prostate gland of rat as...
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Varying expression levels of colony stimulating factor receptors in disease states and different leukocytes

Lee KY, Suh BG, Kim JW, Lee WB, Kim SY, Kim YY, Lee JH, Lim JH, Lim MS, Kang CS, Han KJ

  • KMID: 755101
  • Exp Mol Med.
  • 2000 Dec;32(4):210-215.
Administration of G-CSF may not always respond in rise of neutrophil counts in different patient population. In order to understand a possible inter-relationship between the G-CSF and GM-CSF...
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Environments of ethidium binding to allosteric Dna: II. Accessibility, mobility and mode of binding

Suh DC

  • KMID: 755100
  • Exp Mol Med.
  • 2000 Dec;32(4):204-209.
DNA binding compounds were previously shown to bind to the right-handed DNA forms and hybrid B-Z forms in a highly cooperative manner and indicate that structural specificity plays...
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Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity

Kim HS, Jeong SY, Lee JH, Kim BE, Kim JW, Jeong SW, Kim IK

  • KMID: 755099
  • Exp Mol Med.
  • 2000 Dec;32(4):197-203.
3-Deazaadenosine (DZA), one of the potent inhibitors of S-adenosylhomocysteine hydrolase, is known to possess several biological properties including an induction of apoptosis. To evaluate a possibility that DZA...
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Alternative splicing in 5'-untranslational region of STK-15 gene, encoding centrosome associated kinase, in breast cancer cell lines

Shin SO, Lee KH, Kim JH, Baek SH, Park JW, Gabrielson EW, Kwon TK

  • KMID: 755098
  • Exp Mol Med.
  • 2000 Dec;32(4):193-196.
Centrosomes maintain genomic stability by establishing the bipolar spindles during cell division and, execute accurate segregation of chromosomes during mitosis. In this study, we have demonstrated that there...
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Characterization of an unusual variant mRNA of human lysosomal alpha-mannosidase

Sun H, Wolfe JH

  • KMID: 755097
  • Exp Mol Med.
  • 2000 Dec;32(4):187-192.
Lysosomal alpha-mannosidase (EC 3.2.1.24) is an exoglycosidase in the glycoprotein degradation pathway and is encoded by a 3.0 kb cDNA. A 2.3 kb cDNA from a minor species...
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Atrial natriuretic peptide induces rat peritoneal mast cell activation by cGMP-independent and calcium uptake-dependent mechanism

Chai OH, Lee YH, Han EH, Kim HT, Lee MS, Song CH

  • KMID: 755096
  • Exp Mol Med.
  • 2000 Dec;32(4):179-186.
Atrial natriuretic peptide (ANP), a 28 amino acid basic polypeptide, is known to induce histamine release from human and rat mast cells in vitro and cause a wheel...
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