- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Redox signaling: hydrogen peroxide as intracellular messenger
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Rhee SG
- KMID: 1029931
- Exp Mol Med.
- 1999 Jun;31(2):53-59.
Although superoxide anions (O2.-) and H2O2 are generally considered to be toxic by-products of respiration, recent evidence suggests that the production of these reactive oxygen species (ROS) might be an integral component... -
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- Change of plasma lipoproteins by heparin-released lipoprotein lipase
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Yang JY, Kim TK, Koo BS, Park BH, Park JW
- KMID: 1029932
- Exp Mol Med.
- 1999 Jun;31(2):60-64.
Lipoprotein lipase (LPL) is known to be attached to the luminal surface of vascular endothelial cells in a complex with membrane-bound heparan sulfate, and released into blood stream by heparin. LPL that... -
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- Characterization of regulatory elements on the promoter region of human ATP-citrate lyase
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Moon YA, Kim KS, Cho UH, Yoon DJ, Park SW
- KMID: 1029940
- Exp Mol Med.
- 1999 Jun;31(2):108-114.
ATP-citrate lyase (ACL), an enzyme catalyzing the first step in biosynthesis of fatty acids, is induced during the lipogenesis and cholesterologenesis. We demonstrate that the region -213 to -128 of human ACL... -
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- Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin
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Park EJ, Chang JH, Kim JS, Chung SI, Yum JS
- KMID: 1029939
- Exp Mol Med.
- 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine... -
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- Synthesis of recombinant blood coagulation factor VIII (FVIII) heavy and light chains and reconstitution of active form of FVIII
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Oh SH, Lee MY, Song DW
- KMID: 1029938
- Exp Mol Med.
- 1999 Jun;31(2):95-100.
FVIII is synthesized as a single chain precursor of approximately 280 kD with the domain structure of A1-A2-B-A3-C1-C2 and it circulates as a series of metal ion-linked heterodimers that result from cleavages... -
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- Asp 280 residue is important in the activity of the Escherichia coli leader peptidase
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Sung MS, Park KS
- KMID: 1029933
- Exp Mol Med.
- 1999 Jun;31(2):64-69.
Leader peptidase is a novel serine protease in Escherichia coli, which catalyzes the cleavage of amino-terminal signal sequences from exported proteins. It is an integral membrane protein containing two transmembrane segments with... -
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- Induction of fibronectin gene expression by inhibitors of protein phosphatase type 2B in normal and transformed fibroblasts
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Rhew JH, Shin YA, Lee BH, Park RW, Kim IS
- KMID: 1029934
- Exp Mol Med.
- 1999 Jun;31(2):71-75.
Two intracellular signal pathways mediated by cAMP and protein kinase C (PKC) were involved in the regulation of FN gene expression (Lee et al., Exp. Mol. Med. 30: 240, 1998). In this... -
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- Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins
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Shah BH
- KMID: 1029937
- Exp Mol Med.
- 1999 Jun;31(2):89-94.
Previously it has been shown that persistent activation of the stimulatory adenylyl cyclase pathway with cholera toxin (CT) downregulates the Gs alpha polypeptide (80%) in a cAMP-independent manner in C6 glioma cells... -
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- Role of Ras/ERK-dependent pathway in the erythroid differentiation of K562 cells
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Kang CD, Do IR, Kim KW, Ahn BK, Kim SH, Chung BS, Jhun BH, Yoo MA
- KMID: 1029935
- Exp Mol Med.
- 1999 Jun;31(2):76-82.
The chronic myelogenous leukemic K562 cell line carrying Bcr-Abl tyrosine kinase is considered as pluripotent hematopoietic progenitor cells expressing markers for erythroid, granulocytic, monocytic, and megakaryocytic lineages. Here we investigated the signaling modulations... -
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