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The regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase

Kang IS, Choi SL, Kim SS, Kim SJ, Ha JH, Oh SM, Kim SS

  • KMID: 755019
  • Exp Mol Med.
  • 1998 Dec;30(4):263-269.
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor receptors is not...
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Calpain inhibitors reduce the cornified cell envelope formation by inhibiting proteolytic processing of transglutaminase 1

Kim SY, Bae CD

  • KMID: 755018
  • Exp Mol Med.
  • 1998 Dec;30(4):257-262.
Calpain I (mu-calpain) and II (m-calpain) are well known calcium-activated neutral cysteine proteases. Many reports have shown that activation of calpain is related to cataract formation, neuronal degeneration, blood clotting, ...
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Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells

Kim IS

  • KMID: 755017
  • Exp Mol Med.
  • 1998 Dec;30(4):252-256.
Flap endo/exonuclease-1 (FEN-1) recognizes 5'-flap DNA structures that have been proposed to be important intermediates in DNA replication, repair and recombination, and cleaves the double strand-single strand junction of flap ...
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Genomic structure of the regulatory region of the voltage-gated calcium channel alpha 1D

Kim HL, Chang YJ, Lee SM, Hong YS

  • KMID: 755016
  • Exp Mol Med.
  • 1998 Dec;30(4):246-251.
In excitable and endocrine organs, calcium influxes through the L-type voltage-gated calcium channel (VGCC) which is composed of four (alpha 1, alpha 2, beta, and gamma) subunits. Temporal and spatial...
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Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells

Lee BH, Park RW, Kim IS

  • KMID: 755015
  • Exp Mol Med.
  • 1998 Dec;30(4):240-245.
We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Dibutyryl cAMP increased FN synthesis and mRNA levels, while PMA inhibited...
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Retainment of membrane binding capacity of non-palmitoylated Gs alpha mutants expressed in COS-1 cells

Yang JM, Cho CH, Bae CD, Juhnn YS

  • KMID: 755014
  • Exp Mol Med.
  • 1998 Dec;30(4):235-239.
Heterotrimeric guanine nucleotide binding regulatory proteins (G proteins) transduce extracellular signals into intracellular signals by coupling receptors and effectors. Because most of the G protein-coupled receptors are integral proteins, the...
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Partial purification of protein farnesyl cysteine carboxyl methyltransferase from bovine brain

Yoo BC, Kang MS, Kim SD, Lee YS, Choi SY, Ryu CK, Park GH, Han JS

  • KMID: 755013
  • Exp Mol Med.
  • 1998 Dec;30(4):227-234.
C-terminal farnesyl cysteine carboxyl methylation has been known to be the last step in the post-translational modification processes of several important signal transduction proteins in eukaryotes including ras related GTP...
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The effects of oxygen radicals on the activity of nitric oxide synthase and guanylate cyclase

Kim SM, Byun JS, Jung YD, Kang IC, Choi SY, Lee KY

  • KMID: 755012
  • Exp Mol Med.
  • 1998 Dec;30(4):221-226.
Reactive oxygen species such as superoxides, hydrogen peroxide (H2O2) and hydroxyl radicals have been suggested to be involved in the catalytic action of nitric oxide synthase (NOS) to produce NO...
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Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells

Park JI, Uhlinger D, Chung BS, Kim IH, Kwak JY

  • KMID: 755011
  • Exp Mol Med.
  • 1998 Dec;30(4):214-220.
Human promyelocytic leukemia cells (HL-60) have been used as a model system in which to study the effects of protein phosphatase inhibitors on NADPH-oxidase activation. Since O2- is generated by...
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Nucleolus contains signal molecules that constitute membrane-nucleolus linked pathway

Jeong JS, Kim IH, Lee HJ, Choi YC

  • KMID: 755010
  • Exp Mol Med.
  • 1998 Dec;30(4):205-213.
Since there have been very few studies on nucleolar signaling, an attempt was made to establish nucleolar signal pathways which link the cell membrane to the nucleolus for the transfer...
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Induction of proliferation in resting B-cells by a factor released by activated mouse spleen cells

Puri N, Saxena RK

  • KMID: 755009
  • Exp Mol Med.
  • 1998 Dec;30(4):199-204.
Mouse spleen cells activated in a mixed lymphocyte reaction release a soluble factor, which induces a significant proliferative response in fresh mouse spleen cells. This proliferation inducing factor (PIF) was...
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Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Hong YS, Chang JH, Kwon OJ, Ham YA, Choi JH

  • KMID: 755008
  • Exp Mol Med.
  • 1998 Dec;30(4):192-198.
The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-transferase class mu (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer....
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Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride

Qin G, Ning Y, Su J, Shinozuka , Lotlikar P

  • KMID: 755007
  • Exp Mol Med.
  • 1998 Dec;30(4):186-191.
The effect of carbon tetrachloride (CCl4) on aflatoxin B1 (AFB1)-induced enzyme altered hepatic foci has been examined in young male Fischer rats given AIN-76A diet. A single i.p. dose of...
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Isolation and characterization of brain-specific transglutaminases from rat

Kwak SJ, Kim SY, Kim YS, Song KY, Kim IG, Park SC

  • KMID: 755006
  • Exp Mol Med.
  • 1998 Dec;30(4):177-185.
The relevance of transglutaminases with neural function and several disorders has been emphasized recently. Especially, many polypeptides associated with neurodegenerative diseases are suggested to be putative transglutaminase substrates such as...
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