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Active adenosine transporter-mediated adenosine entrance into HL-60 cells leads to the induction of apoptosis through down-regulation of c-Myc

Hong SH, Jeong SY, Ahn SG, Hwang IS, Kim IK

  • KMID: 2052796
  • Exp Mol Med.
  • 1997 Sep;29(3):183-190.
Although adenosine (Ado) is being recently recognized as a potent inducer of apoptosis, molecular mechanism of apoptosis by Ado remains to be elucidated. In this study we observed that c-Myc...
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Expression of p53 gene in hepatocellular carcinomas induced by aflatoxin B1 with or without human hepatitis B virus in tree shrews

Su J, Qin G, Yan R, Huang D, Yang C, Huang G, Lotlikar P

  • KMID: 2052795
  • Exp Mol Med.
  • 1997 Sep;29(3):177-182.
Using tree shrew as an animal model, our previous studies have demonstrated synergistic effects of aflatoxin B-1 (AFB(1)) and human hepatitis B virus (HHBV) in the induction of hepatocellular carcinoma...
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Hemin inhibits lipid peroxidation induced by ascorbate/FeSO4 and 2,2'-azobis-2-amidino-propane hydrochloride (ABAP)

Jung YD, Chay KO, Song DU, Moon JS, Yang SY, Lee MW, Ahn BW

  • KMID: 2052794
  • Exp Mol Med.
  • 1997 Sep;29(3):171-175.
Hemin blocked lipid peroxidations induced by either ascorbate/FeSO4, a metal-catalyzed oxidation system, or 2,2'-azobis-2-amidino-propane hydrochloride (ABAP) which produces peroxy radicals at constant rates. Hemin at very low micromolar concentrations strongly...
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Mutations of DNA repair associated gene, APEX in human colorectal cancer

Oh SH, Park HB, Kim YJ

  • KMID: 2052793
  • Exp Mol Med.
  • 1997 Sep;29(3):165-170.
Structural and functional changes in the major apurinic/apyrimidinic DNA endonuclease (APEX) gene in human colorectal cancers were investigated. DNAs were prepared from surgically removed 25 human colorectal tissues and direct...
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The apolipoprotein E genotyping using the PCR-RFLP was useful to linkage analysis of Alzheimer's disease families

Oh MJ, Chung EK, Shin YM, Lee KO, Park YS

  • KMID: 2052792
  • Exp Mol Med.
  • 1997 Sep;29(3):161-164.
Apolipoprotein E (ape E) has three common alleles (ape epsilon 2, epsilon 3 and epsilon 4) that code for three major isoforms E2, E3 and E4. The isoforms differ from...
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Telomerase activity in benign and malignant human thyroid nodules

Ahn MJ, Tae K, Park YS, Kim IS, Choi IY, Lee HS, Kim SK, Lee YS

  • KMID: 2052791
  • Exp Mol Med.
  • 1997 Sep;29(3):157-160.
Telomerase is a ribonucleoprotein polymerase which contains an integral RNA and synthesizes TTAGGG nucleotide repeats at the ends of chromosomes in vertebrates. Accumulated evidence has indicated that telomerase is stringently...
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Mutations of CDKN2 (MTS1/p16I(NK4A)) and MTS2/p15(INK4B) genes in human stomach, hepatocellular, and cholangio-carcinomas

Kim JR, Kim SY, Lee BH, Kim SW, Kim HJ, Kim JH

  • KMID: 2052790
  • Exp Mol Med.
  • 1997 Sep;29(3):151-156.
The CDKN2 (MTS1/p16(INK4A)) and MTS2/p15(INK4B) genes, encoding cyclin dependent kinase inhibitors, were found to be homozygously deleted at high frequency in cell lines from many different types of cancer and...
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Heat shock proteins and their role in early mammalian development

Walsh DA, Edwards MJ MJ, Smith MS

  • KMID: 2052789
  • Exp Mol Med.
  • 1997 Sep;29(3):139-150.
Elevated body temperature can result from many agents in the natural environment, such as fever, hot weather and heavy exercise. In our modern living conditions additional sources of induced hyperthermia...
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