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The S-genomic RNA of Hantaan virus contains only two trinucleotide repeats at its 5' end and the 3' end of 3'-specific mRNA is truncated and lacks poly-A tail

Dobbs M, Jin MR, Kang CY

  • KMID: 2128630
  • Exp Mol Med.
  • 1997 Mar;29(1):81-83.
No abstract available.
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Membrane activator of the 72 kDa type IV collagenase in malignant breast carcinoma patients: Expression of membrane-type 1-matrix metalloproteinase (MT1-MMP)

Chai KJ, Lee HJ, Lee SJ, Lee KS

  • KMID: 2128629
  • Exp Mol Med.
  • 1997 Mar;29(1):71-79.
In this study, we determined proMMP-2 activating capacity of membrane extract prepared from the tissue of invasive ductal carcinoma of breast by zymogram gel analysis. We compared the effect of...
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Production of IL-12 from gene modified human dermal fibroblasts: A preclinical study for IL-12 cancer gene therapy

Park CH, Kang WK, Oh MS, Kim WS, Yang JH, Lotze MT, Kim SY, Park K, Park CH

  • KMID: 2128628
  • Exp Mol Med.
  • 1997 Mar;29(1):65-69.
Cytokine has been used as an immune stimulator and administered to patients for a treatment of cancer. Interleukin-12 (IL-12) is a potent cytokine which acts through a variety of functions...
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Effect of high glucose on synthesis and gene expression of collagen and fibronectin in cultured vascular smooth muscle cells

Ha SW, Ha SW, Seo YK, Kim JG, Kim IS, Sohn KY, Lee BH, Kim BW

  • KMID: 2128627
  • Exp Mol Med.
  • 1997 Mar;29(1):59-64.
Diabetes mellitus is an important risk factor of atherosclerosis. Although the mechanism for accelerated atherosclerotic disease in diabetes mellitus is not clear, extracellular matrix formation by vascular smooth muscle cells...
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Retroviral-mediated IL-12 gene therapy for advanced murine tumors

Kim SH, An CS, Tahara H, Park CH, Lotze MT, Robbins PD, Kim SY

  • KMID: 2128626
  • Exp Mol Med.
  • 1997 Mar;29(1):53-58.
Interleukin 12 (IL-12), a heterodimeric cytokine, promotes an effective antitumor response against tumors of various histological types when delivered systemically as a protein or locally by gene transfer. We investigated...
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Hormonal regulation of ICAM-1 gene expression in thyroid cells, FRTL-5

An BS, Ku BJ, Park SY, Shin JK, Lee JH, Kim YK, Shong MH, Ro HK

  • KMID: 2128625
  • Exp Mol Med.
  • 1997 Mar;29(1):45-51.
Our previous works have shown that human thyroid follicular cells from Graves' disease and FRTL-5 rat thyroid cells express the intercellular adhesion molecule-1 (ICAM-1) molecule and its expression is upregulated...
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Protein methylation in cellular proliferation and differentiation: Non-histone nuclear methyl acceptor protein(s) during 3'-methyl-4-dimethylaminoazobenzeneinduced hepatocarcinogenesis

Paik MK, Han YJ, Hong JH, Kim JS, Suh KS, Yoon SJ

  • KMID: 2128624
  • Exp Mol Med.
  • 1997 Mar;29(1):35-43.
An accelerating effect of methyl-deficient diet (MDD) on hepatocarcinogenesis and methylation pattern of nuclear protein(s) by S-adenosylmethionine: protein arginine N-methyltransferase (protein methylase I, PM-I) have been studied with 3'-methyl-4-dimethyl- aminoazobenzene(MeDAB)-treated...
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Purification of thrombospondin receptor (CD36) from human platelet membrane

Kim JH, Suk KH, Park NY, Kim SH

  • KMID: 2128623
  • Exp Mol Med.
  • 1997 Mar;29(1):31-34.
Thrombospondin receptor (CD36) has been recently identified in platelets and various cell lines as the receptor for thrombospondin, an adhesive protein required for irreversible aggregation of platelets as well as...
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Purification and characterization of lactate dehydrogenase from Varanus liver

Javed MH M, Azimuddin , Hussain AN, Ahmed A, Ishaq M

  • KMID: 2128622
  • Exp Mol Med.
  • 1997 Mar;29(1):25-30.
Lactate dehydrogenase was purified 21-fold from liver of Varanus bengalensis using colchicine-sepharose column chromatography. The crude enzyme showed two isoenzymes (LDH-5 and LDH-4) by agarose gel electrophoresis (AGE). The purified...
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Modulation by aspartate of ischemia/reperfusion-induced oxidative stress in rat liver

Park YC, Oh SI, Park YH, Park SC

  • KMID: 2128621
  • Exp Mol Med.
  • 1997 Mar;29(1):19-23.
Ischemia-reperfusion injury is related with oxygen free radicals; a reason which has been suggested for this is the conversion of xanthine dehydrogenase (XDH) into xanthine oxidase (XO). In the present...
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The parathyroid hormone-2 receptor: Current status

Usdin TB

  • KMID: 2128620
  • Exp Mol Med.
  • 1997 Mar;29(1):13-17.
G-protein coupled receptors form a large superfamily of plasma membrane proteins which serve a variety of signal transduction roles. New receptors continue to be identified. Based on sequence homology the...
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Cell cycle checkpoint control

Murakami H, Okayama H

  • KMID: 2128619
  • Exp Mol Med.
  • 1997 Mar;29(1):1-11.
Genetic instability is considered to be a major driving force of malignancy of cancer cells, and at least some of cancer-associated genetic instability is known to be caused by defects...
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