- Genome editing: the road of CRISPR/Cas9 from bench to clinic
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Eid A, Mahfouz MM
- KMID: 2361552
- Exp Mol Med.
- 2016 Oct;48(10):e265.
- doi: 10.1038/emm.2016.111
Molecular scissors engineered for site-specific modification of the genome hold great promise for effective functional analyses of genes, genomes and epigenomes and could improve our understanding of the molecular underpinnings... -
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- Mechanisms of aging-related proteinopathies in Caenorhabditis elegans
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Kim DK, Kim TH, Lee SJ
- KMID: 2361550
- Exp Mol Med.
- 2016 Oct;48(10):e263.
- doi: 10.1038/emm.2016.109
Aging is the most important risk factor for human neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Pathologically, these diseases are characterized by the deposition of specific protein aggregates in... -
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- High yields and soluble expression of superoxide dismutases in Escherichia coli due to the HIV-1 Tat peptide via increases in mRNA transcription
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Sun Y, Ye Q, Wu M, Wu Y, Zhang C, Yan W
- KMID: 2361551
- Exp Mol Med.
- 2016 Oct;48(10):e264.
- doi: 10.1038/emm.2016.91
This study aimed to validate the high yield and soluble expression of proteins carrying the transactivator of transcription (Tat) peptide tag, and further explored the potential mechanism by which the... -
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- Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model
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Hong Y, Kim YS, Hong SH, Oh YM
- KMID: 2361553
- Exp Mol Med.
- 2016 Oct;48(10):e266.
- doi: 10.1038/emm.2016.93
There is no therapy currently available that influences the natural history of disease progression in patients with chronic obstructive pulmonary disease (COPD). Although stem cell therapy is considered a potential... -
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- A novel anti-IL4Rα nanoparticle efficiently controls lung inflammation during asthma
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Halwani R, Sultana Shaik A, Ratemi E, Afzal S, Kenana R, Al-Muhsen , Al Faraj A
- KMID: 2361549
- Exp Mol Med.
- 2016 Oct;48(10):e262.
- doi: 10.1038/emm.2016.89
Drug resistance and the harmful side effects accompanying the prolonged corticosteroid treatment of chronic pulmonary diseases prompted the development of more specific anti-inflammatory approaches. Several strategies aiming to block IL4Rα,... -
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