- ROS homeostasis and metabolism: a critical liaison for cancer therapy
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Kim J, Kim J, Bae JS
- KMID: 2362293
- Exp Mol Med.
- 2016 Nov;48(11):e269.
- doi: 10.1038/emm.2016.119
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can... -
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- Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner
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Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel P, Seifert U, Shin EC
- KMID: 2362294
- Exp Mol Med.
- 2016 Nov;48(11):e270.
- doi: 10.1038/emm.2016.98
By changing the relative abundance of generated antigenic peptides through alterations in the proteolytic activity, interferon (IFN)-γ-induced immunoproteasomes influence the outcome of CD8⺠cytotoxic T lymphocyte responses. In the present... -
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- Aldehyde dehydrogenase is used by cancer cells for energy metabolism
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Kang JH, Lee SH, Hong D, Lee JS, Ahn HS, Ahn JH, Seong TW, Lee CH, Jang H, Hong KM, Lee C, Lee JH, Kim SY
- KMID: 2362296
- Exp Mol Med.
- 2016 Nov;48(11):e272.
- doi: 10.1038/emm.2016.103
We found that non-small-cell lung cancer (NSCLC) cells express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms via an informatics analysis of metabolic enzymes in NSCLC and immunohistochemical staining of... -
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- Integrated computational approach to the analysis of RNA-seq data reveals new transcriptional regulators of psoriasis
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Zolotarenko A, Chekalin E, Mesentsev , Kiseleva L, Gribanova , Mehta R, Baranova A, Tatarinova TV, Piruzian E, Bruskin S
- KMID: 2362292
- Exp Mol Med.
- 2016 Nov;48(11):e268.
- doi: 10.1038/emm.2016.97
Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis... -
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- TFAP2C-mediated upregulation of TGFBR1 promotes lung tumorigenesis and epithelial–mesenchymal transition
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Kim W, Kim E, Lee S, Kim D, Chun J, Park KH, Youn H, Youn B
- KMID: 2362297
- Exp Mol Med.
- 2016 Nov;48(11):e273.
- doi: 10.1038/emm.2016.125
TFAP2C (transcription factor-activating enhancer-binding protein 2C) expression has been positively correlated with poor prognosis in patients with certain types of cancer, but the mechanisms underlying TFAP2C-mediated tumorigenesis in non-small-cell lung... -
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- A phosphorylation pattern-recognizing antibody specifically reacts to RNA polymerase II bound to exons
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Han J, Lee JH, Park S, Yoon S, Yoon A, Hwang DB, Lee HK, Kim MS, Lee Y, Yang WJ, Youn HD, Kim H, Chung J
- KMID: 2362295
- Exp Mol Med.
- 2016 Nov;48(11):e271.
- doi: 10.1038/emm.2016.101
The C-terminal domain of RNA polymerase II is an unusual series of repeated residues appended to the C-terminus of the largest subunit and serves as a flexible binding scaffold for... -
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- Transglutaminase 2 is dispensable but required for the survival of mice in dextran sulfate sodium-induced colitis
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Jeong EM, Son YH, Choi Y, Kim JH, Lee JH, Cho SY, Kim IG
- KMID: 2362291
- Exp Mol Med.
- 2016 Nov;48(11):e267.
- doi: 10.1038/emm.2016.95
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes crosslinking, polyamination or deamidation of glutamine residues in proteins. It has been reported that TG2 is involved in the pathogenesis... -
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