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Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity

Park MH, Bae SS, Choi KY, Min DS

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein...
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Clinicopathological values of NBS1 and DNA damage response genes in epithelial ovarian cancers

Lee YK, Park NH, Lee H

Epithelial ovarian cancers (EOCs) are highly lethal gynecological malignancies with a high recurrence rate. Therefore, developing prognostic markers for recurrence after chemotherapy is crucial for the treatment of ovarian cancers....
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Clinical implications of proliferation activity in T1 or T2 male gastric cancer patients

Kim YW, Eom BW, Kook MC, Kim HS, Kim MK, Hwang HL, Chandra V, Poojan S, Song Y, Koh JS, Bae CD, Ro J, Hong KM

Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still...
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Serum amyloid A inhibits RANKL-induced osteoclast formation

Oh E, Lee HY, Kim HJ, Park YJ, Seo JK, Park JS, Bae YS

When mouse bone marrow-derived macrophages were stimulated with serum amyloid A (SAA), which is a major acute-phase protein, there was strong inhibition of osteoclast formation induced by the receptor activator...
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