- Cotinine-conjugated aptamer/anti-cotinine antibody complexes as a novel affinity unit for use in biological assays
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Park S, Hwang D, Chung J
- KMID: 1389735
- Exp Mol Med.
- 2012 Sep;44(9):554-561.
Aptamers are synthetic, relatively short (e.g., 20-80 bases) RNA or ssDNA oligonucleotides that can bind targets with high affinity and specificity, similar to antibodies, because they can fold into unique,... -
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- Over-expression of extracellular superoxide dismutase in mouse synovial tissue attenuates the inflammatory arthritis
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Yu DH, Yi JK, Yuh HS, Park SJ, Kim HJ, Bae KB, Ji YR, Kim NR, Park SJ, Kim DH, Kim SH, Kim MO, Lee JW, Ryoo ZY
- KMID: 1389732
- Exp Mol Med.
- 2012 Sep;44(9):529-535.
Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase... -
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- Cyclooxygenase-2 inhibitors modulate skin aging in a catalytic activity-independent manner
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Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim WJ, Han JA
- KMID: 1389733
- Exp Mol Med.
- 2012 Sep;44(9):536-544.
It has been proposed that the pro-inflammatory catalytic activity of cyclooxygenase-2 (COX-2) plays a key role in the aging process. However, it remains unclear whether the COX-2 activity is a... -
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- Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way
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Kim M, Song K, Jin EJ, Sonn J
- KMID: 1389731
- Exp Mol Med.
- 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation... -
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- Inhibition of mouse brown adipocyte differentiation by second-generation antipsychotics
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Oh JE, Cho YM, Kwak SN, Kim JH, Lee KW, Jung H, Jeong SW, Kwon OJ
- KMID: 1389734
- Exp Mol Med.
- 2012 Sep;44(9):545-553.
Brown adipose tissue is specialized to burn lipids for thermogenesis and energy expenditure. Second-generation antipsychotics (SGA) are the most commonly used drugs for schizophrenia with several advantages over first-line drugs,... -
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- Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes
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Jeon MJ, Leem J, Ko MS, Jang JE, Park HS, Kim HS, Kim M, Kim EH, Yoo HJ, Lee CH, Park IS, Lee KU, Koh EH
- KMID: 1389736
- Exp Mol Med.
- 2012 Sep;44(9):562-570.
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress are considered the key determinants of insulin resistance. Impaired mitochondrial function in obese animals was shown to induce the ER stress response, resulting... -
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