- S-Adenosyl-L-methionine ameliorates TNFalpha-induced insulin resistance in 3T3-L1 adipocytes
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Moon MK, Kim M, Chung SS, Lee HJ, Koh SH, Svovoda P, Jung MH, Cho YM, Park YJ, Choi SH, Jang HC, Park KS, Lee HK
- KMID: 946634
- Exp Mol Med.
- 2010 May;42(5):345-352.
- doi: 10.3858/emm.2010.42.5.036
An association between inflammatory processes and the pathogenesis of insulin resistance has been increasingly suggested. The IkappaB kinase-beta (IKK-beta)/ nuclear factor-kappaB (NF-kappaB) pathway is a molecular mediator of insulin resistance.... -
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- Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis
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Park HJ, Ban YL, Byun D, Park SH, Jung KC
- KMID: 946635
- Exp Mol Med.
- 2010 May;42(5):353-365.
- doi: 10.3858/emm.2010.42.5.037
Here, we show that the interaction between two membrane proteins, the mouse homologue of CD99 (designated D4) and its ligand, paired immunoglobulin-like type 2 receptor (PILR), is one of the... -
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- Overexpression and unique rearrangement of VH2 transcripts in immunoglobulin variable heavy chain genes in ankylosing spondylitis patients
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Kim YJ, Kim N, Lee MK, Choi HJ, Baek HJ, Nam CH
- KMID: 946631
- Exp Mol Med.
- 2010 May;42(5):319-326.
- doi: 10.3858/emm.2010.42.5.030
To identify immunoglobulin variable heavy chain (VH) gene usages in Korean ankylosing spondylitis (AS) patients, expression level of VH2 genes from peripheral blood mononuclear cells (PBMCs) of 8 AS patients... -
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- Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
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Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH
- KMID: 946639
- Exp Mol Med.
- 2010 May;42(5):395-405.
- doi: 10.3858/emm.2010.42.5.041
2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase... -
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- beta-Lapachone suppresses radiation-induced activation of nuclear factor-kappaB
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Dong GZ, Oh ET, Lee H, Park MT, Song CW, Park HJ
- KMID: 946632
- Exp Mol Med.
- 2010 May;42(5):327-334.
- doi: 10.3858/emm.2010.42.5.034
Anticancer effects of beta-lapachone (beta-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced forms of... -
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- Involvement of MITF-A, an alternative isoform of mi transcription factor, on the expression of tryptase gene in human mast cells
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Lee SH, Lee JH, Lee YM, Kim DK
- KMID: 946636
- Exp Mol Med.
- 2010 May;42(5):366-375.
- doi: 10.3858/emm.2010.42.5.038
Mast cells play a central role in the initiation and development of allergic diseases through release of various mediators. Tryptase has been known to be a key mediator in mast... -
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- p190RhoGAP and Rap-dependent RhoGAP (ARAP3) inactivate RhoA in response to nerve growth factor leading to neurite outgrowth from PC12 cells
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Jeon CY, Kim HJ, Lee JY, Kim J, Kim SC, Park JB
- KMID: 946633
- Exp Mol Med.
- 2010 May;42(5):335-344.
- doi: 10.3858/emm.2010.42.5.035
Rat pheochromocytoma (PC12) cells have been used to investigate neurite outgrowth. Nerve growth factor (NGF) has been well known to induce neurite outgrowth from PC12 cells. RhoA belongs to Ras-related... -
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- Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
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Lee JH, Won SM, Suh J, Son SJ, Moon GJ, Park UJ, Gwag BJ
- KMID: 946638
- Exp Mol Med.
- 2010 May;42(5):386-394.
- doi: 10.3858/emm.2010.42.5.040
The endoplasmic reticulum (ER) stress results from disrupted protein folding triggered by protein mutation or oxidation, reduced proteasome activity, and altered Ca2+ homeostasis. ER stress is accompanied by activation of... -
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- Genetic association of angiogenesis- and hypoxia-related gene polymorphisms with osteonecrosis of the femoral head
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Hong JM, Kim TH, Kim HJ, Park EK, Yang EK, Kim SY
- KMID: 946637
- Exp Mol Med.
- 2010 May;42(5):376-385.
- doi: 10.3858/emm.2010.42.5.039
Multiple factors have been implicated in the development of osteonecrosis of the femoral head (ONFH). In particular, non-traumatic ONFH is directly or indirectly related to injury of the vascular supply... -
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