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TNF-a-Inhibition Improves the Biocompatibility of Porous Polyethylene Implants In Vivo

Hussain T, Gellrich D, Siemer S, Reichel CA, Eckrich J, Dietrich D, Knauer SK, Stauber RH, Strieth S

BACKGROUND: To improve the biocompatibility of porous polyethylene (PPE) implants and expand their application range for reconstructive surgery in poorly vascularized environments, implants were coated with tumor necrosis factor a...
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The Effect of Tumor Necrosis Factor-Alpha Inhibitors on Uveitis in Patients with Ankylosing Spondylitis

Lee S, Park YJ, Lee JY

BACKGROUND: Tumor necrosis factor-alpha (TNF-α) inhibitors (TNFis), which are the main treatment for ankylosing spondylitis (AS), have been reported not only to reduce the incidence of anterior uveitis (AU) but...
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Long Term Safety and Efficacy of Etanercept in Juvenile Idiopathic Arthritis in a Single Center

Bang MH, Kim KN

OBJECTIVE: Our aim was to investigate the long term safety and efficacy of etanercept in children with juvenile idiopathic arthritis (JIA). METHODS: The study subjects were the 90 JIA patients treated...
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Real-World Experience with Etanercept Therapy and the Switching Pattern among Korean Patients with Psoriasis after Withdrawal of Etanercept

Choi CW, Lee JS, Yu DA, Kim BR, Youn SW

BACKGROUND: The efficacy and safety of etanercept in the treatment of psoriasis has been proven, and the drug was approved for the treatment of moderate to severe psoriasis. However, there...
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Tumor Necrosis Factor Alpha Blocker-Induced Erythrodermic Sarcoidosis in with Juvenile Rheumatoid Arthritis: A Case Report and Review of the Literature

Park SK, Hwang PH, Yun SK, Kim HU, Park J

The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis...
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Dose Optimization for Single Intradiscal Administration of the Tumor Necrosis Factor-α Inhibitor, Etanercept, in Rat Disc Injury Models

Inage K, Orita S, Yamauchi K, Suzuki T, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Takahashi , Ohtori S

STUDY DESIGN: Experimental animal study. PURPOSE: We aimed to determine the optimal dose of a single direct injection of the tumor necrosis factor (TNF)-α inhibitor, etanercept, by using the rat model...
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A Case of Sarcoidosis That Improved upon Discontinuation of Etanercept

Kang JH, Ahn JH, Yu JE, Kim JE, Yim YR, Lee JW, Lee KE, Park DJ, Wen L, Park YW, Lee SS

A 31-year-old man who had been prescribed etanercept over a 3-year period for treatment of ankylosing spondylitis presented with newly developed dry cough, chills, myalgia, and weight loss. Chest computed...
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Nodular Vasculitis That Developed during Etanercept (Enbrel) Treatment in a Patient with Psoriasis

Park SB, Chang IK, Im M, Lee Y, Kim CD, Seo YJ, Lee JH

Nodular vasculitis was introduced by Montgomery for cases of erythema induratum-like lesions that were not associated with tuberculosis. Nodular vasculitis has been associated with both nontuberculous infections and noninfectious conditions....
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Efficacy of Direct Injection of Etanercept into Knee Joints for Pain in Moderate and Severe Knee Osteoarthritis

Ohtori S, Orita S, Yamauchi K, Eguchi Y, Ochiai N, Kishida S, Kuniyoshi , Aoki Y, Nakamura J, Ishikawa T, Miyagi M, Kamoda H, Suzuki M, Kubota G, Sakuma Y, Oikawa Y, Inage K, Sainoh T, Sato J, Shiga Y, Abe K, Fujimoto K, Kanamoto H, Toyone T, Inoue G, Takahashi

PURPOSE: Osteoarthritic (OA) pain is largely considered to be inflammatory pain. However, during the last stage of knee OA, sensory nerve fibers in the knee are shown to be significantly...
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Pulmonary Cryptococcosis in a Patient with Ankylosing Spondylitis treated with Etanercept

Lim CH, Lee SH, Kim HY, Kim WS, Kang S, Kwon SW, Kim J, Park SY, An SH, Yu HM, Kim HR

Ankylosing spondylitis (AS) is a chronic inflammatory disorder, commonly characterized by inflammation of axial skeleton and development of enthesopathies. Tumor necrosis factor inhibitors (TNFi) shows good therapeutic responses in AS...
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Rheumatoid Arthritis with Secondary Amyloidosis and Chronic Kidney Disease with a Good Response to Etanercept

Kim HW, Noh JW, Kim J

Secondary amyloidosis is a severe complication of refractory rheumatoid arthritis for which no effective treatment exists. Although the benefits of tumor necrosis factor alpha inhibitors in rheumatoid arthritis treatment are...
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Interstitial Lung Disease That Occurred during Treatment with Etanercept (Enbrel(R)) of Psoriasis Patients

Park SB, Kim HR, Im M, Lee Y, Seo YJ, Lee JH

  • KMID: 2246592
  • Korean J Dermatol.
  • 2013 Sep;51(9):709-712.
Etanercept is widely used to treat autoimmune rheumatic, digestive, and dermatologic diseases such as psoriasis. It acts as a competitive inhibitor of tumor necrosis factor (TNF)-alpha and has acceptable safety...
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Refractory Plaque Psoriasis Treated with a Combination of Etanercept and Low Dose Methotrexate

Lim HS, Yun SJ, Lee JB, Kim SJ, Won YH, Lee SC

  • KMID: 2388395
  • Korean J Dermatol.
  • 2013 Jun;51(6):438-441.
Etanercept has been proven to be highly effective to moderate severe plaque psoriasis. Alternative biologics or combination therapies of etanercept with other systemic agents have been recommended to patients who...
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Safety and Efficacy Evaluation for the Addition of Either Etanercept or Leflunomide in Korean Rheumatoid Arthritis Patients Inadequately Responding to Methotrexate

Joo K, Park W, Kwon SR, Lim MJ

OBJECTIVE: To compare the safety and efficacy associated with the addition of etanercept (ETN) with that of leflunomide (LEF) in Korean rheumatoid arthritis (RA) patients, who inadequately respond to methotrexate...
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Etanercept Treatment in Ankylosing Spondylitis Hip Lesions

Kim YC, Moon SW

PURPOSE: To evaluate the efficacy of etanercept in patients with an ankylosing spondylitis hip lesion. MATERIALS AND METHODS: Between March 2008 and December 2011, this study evaluated 13 patients with hip...
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Switching to Etanercept in Intestinal Behcet's Disease Complicated by Secondary Non-response to Anti-TNF-alpha Antibodies

Lee S, Kim TO, Park CS, Kim HK, Kim SH

The efficacy of anti-TNF-alpha antibodies including infliximab and adalimumab for refractory intestinal Behcet's disease has recently been demonstrated in a series of case reports. The efficacy of switching to a...
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Etanercept-induced Leukocytoclastic Vasculitis

Kim JH, Shin WU, Baek YS, Oh CH, Kim JH

  • KMID: 2247310
  • Korean J Dermatol.
  • 2012 Sep;50(9):807-809.
Leukocytoclastic vasculitis is a small vessel inflammatory disease mediated mostly by deposition of immune complexes. Etanercept (Enbrel(R)) is widely used not only for rheumatic disorders such as ankylosing spondylitis but...
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A Case of Macropharge Activation Syndrome Successfully Treated with Combination Therapy Including Etanercept

Sim YS, Kim HS, Kim KN

Macrophage activation syndrome (MAS) is a severe, potentially life-threatening complication of childhood systemic inflammatory disorder, primarily systemic onset juvenile rheumatoid arthritis (SoJRA). It is characterized by pancytopenia, liver insufficiency, coagulopathy,...
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Juvenile Rheumatoid Arthritis in Children with Ebstein-barr Virus Infection

Shim YS, Kim JS, Lee KK, Lee KM, Kim KN

OBJECTIVE: Juvenile rheumatoid arthritis (JRA) may occur in the wake of infection with several viruses including Ebstein-barr virus (EBV). EBV remains an interesting target. To determine the possible role of...
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A Case of Acrodermatitis Continua of Hallopeau Treated with Etanercept

Park J, Lee Y, Noh S, Cho S, Park CO, Lee KH

  • KMID: 2247517
  • Korean J Dermatol.
  • 2012 Jan;50(1):92-94.
Acrodermatitis continua of Hallopeau (ACH) is a rare form of acropustular eruption characterized by a presence of aseptic pustules on inflammatory periungual or subungual regions. Frequently accompanied by paronychia, atrophic...
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