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The Efficacy of Short-term Administration of Revaprazan on Gastroesophageal Reflux Symptoms: Comparison with Half Dose Esomeprazole, a Pilot Study

Lee HM, Kim BW, Kim JS, Im EJ, Kim JI, Kang BK, Ji JS, Lee BI, Choi H

BACKGROUND/AIMS: Revaprazan, an acid pump antagonist, is a kind of gastric acid suppressant and is prescribed for the treatment of peptic ulcers and gastritis. However, the efficacy of revaprazan on...
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Effects of esomeprazole premedication on gastric pH during laparoscopic surgery

Lee SI, Choi YK, Kang WJ, Park SW, Yi JW, Sung JK

BACKGROUND: The use of CO2 for pneumoperitoneum during laparoscopic surgery provokes a decrement in the gastric pH. Since the incidence rate of PONV increases after laparoscopic surgery, the possibility of...
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Multicenter Study to Evaluate the Effect of Esomeprozole in Gastro-esophageal Reflux Disease

Kim JJ, Lee SY, Rhee PL, Myung SJ, Kim JH, Choi MG, Kim SW, Lee OY, Rew JS, Joo YE, Choi SC, Kim TH, Kim SK, Jeong HY, Lee BS, Kang DH, Koo JY, Rhee JC

  • KMID: 2307537
  • Korean J Neurogastroenterol Motil.
  • 2003 Dec;9(2):92-101.
BACKGROUND/AIMS: Esomeprazole, an S-isomer of omeprazole, has a potent acid-suppressive effect. It has been prescribed for years, but no reported data had been available with respect to Korean patients. We...
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A Double-blind, Randomized, Multicenter Clinical Trial Investigating the Efficacy and Safety of Esomeprazole Single Therapy Versus Mosapride and Esomeprazole Combined Therapy in Patients with Esophageal Reflux Disease

Lee JY, Kim SK, Cho KB, Park KS, Kwon JG, Jung JT, Kim EY, Jang BI, Lee SH, Daegu-Gyeongbuk Gastrointestinal Study Group (DGSG)

  • KMID: 2433522
  • J Neurogastroenterol Motil.
  • 2017 Apr;23(2):218-228.
  • doi: 10.5056/jnm16100
BACKGROUND/AIMS: We aim to evaluate the efficacy and safety of combination therapy in erosive reflux disease (ERD) patients by comparing endoscopic healing rates according to the Los Angeles classification for...
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Anaphylaxis to lansoprazole with tolerance to other proton pump inhibitors

Park IY, Do BJ, Ahn JS, Lee JH, Lee GY, Kim S, Choi JH

Anaphylaxis to proton pump inhibitors (PPIs) has rarely been reported. Different patterns of cross-reactivity between PPIs have also been demonstrated using skin tests. Here, we report a case of anaphylaxis...
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The Effect of Esomeprazole 40 mg Single Therapy in Patients with Non-Erosive Reflux Disease Who Are Resistant to Standard-Dose Proton Pump Inhibitor Therapy: An Open-Label Multicenter Study

Sung JK, Kim TH, Hong SJ, Kim SG, Jung HY, Lee YC, Jang BI, Park SH

BACKGROUND/AIMS: Despite the efficacy of proton pump inhibitor (PPI) treatment, a considerable number of patients with non-erosive reflux disease (NERD) are resistant to treatment with a PPI at the standard...
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Dual Therapy Trial Using Esomeprazole and Amoxicillin as Third-line Rescue Therapy for Helicobacter pylori Infection

Park HK, Lee DH, Suh S, Seo PJ, Kim N, Jeong SH, Kim JW, Hwang JH, Park YS, Lee SH, Shin CM

  • KMID: 2165492
  • Clin Endosc.
  • 2011 Sep;44(1):33-37.
BACKGROUND/AIMS: The purpose of this study was to evaluate the efficacy and tolerability of dual therapy consisting of esomeprazole and amoxicillin as a rescue therapy for Helicobacter pylori infection. METHODS: From...
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Esophagogastric Junction Contractility Integral Reflect the Anti-reflux Barrier Dysfunction in Patients with Gastroesophageal Reflux Disease

Xie C, Wang J, Li Y, Tan N, Cui Y, Chen M, Xiao Y

  • KMID: 2367452
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):27-33.
  • doi: 10.5056/jnm16008
BACKGROUND/AIMS: Anti-reflux barrier dysfunction is one of the primary mechanisms in gastroesophageal reflux disease (GERD) pathogenesis. The esophagogastric junction contractile integral (EGJ-CI) is a new metric adopted to evaluate the...
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Dilated Intercellular Spaces of Esophageal Epithelium in Korean Reflux Esophagitis and Its Reversibility after Esomeprazole Treatment

Kim JH, Jee SR, Park SJ, Yang SY, Park ET, Lee YJ, Lee SH, Seol SY, Chung JM

  • KMID: 2255751
  • Korean J Neurogastroenterol Motil.
  • 2006 Jun;12(1):19-24.
BACKGROUND/AIMS: It has been demonstrated that dilated intercellular spaces of esophageal epithelium are a marker of tissue injury in Western gastroesophageal reflux disease (GERD); which heals after proton pump inhibitor...
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Proton Pump Inhibition Enhances the Cytotoxicity of Paclitaxel in Cervical Cancer

Song T, Jeon HK, Hong JE, Choi JJ, Kim TJ, Choi CH, Bae DS, Kim BG, Lee JW

PURPOSE: This study was conducted to investigate whether a proton pump inhibitor (PPI) could enhance chemosensitivity via the inhibition of vacuolar-type H⁺ ATPase (V-ATPase) in cervical cancer. MATERIALS AND METHODS: The...
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The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study

Hong SJ, Park SH, Moon JS, Shin WG, Kim JG, Lee YC, Lee DH, Jang JY, Kim JJ, Lee HL, Lee SW, Hwangbo Y, Xu J, Wang B, Xue Z, Liu F, Yuan Y, Leelakusolvong S, Dy F

BACKGROUND/AIMS: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. METHODS: A total of 501 patients with reflux esophagitis were randomized into...
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Eradication Rates of 10-day Sequential Therapy for Helicobacter pylori: Results of an 8-year Prospective Study Conducted at a Tertiary Korean Hospital

Yoon K, Kim N

BACKGROUND/AIMS: The Helicobacter pylori (H. pylori) eradication rate of standard triple therapy is unsatisfactory in Korea, and sequential therapy (SQT) has been suggested to be a practical first-line alternative regimen....
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Diagnostic Significance of One-week Esomeprazole Treatment in Gastro-esophageal Reflux Disease

Jung HY, Jung KW, Huh KC, Jee SR, Choi SC, Lee JH, Lee IS, Lee YC, Lee KJ, Shim KN, Park HS, Park HJ, GERD Club of the Korean Society of Neurogastroenterology and Motility

  • KMID: 2307430
  • Korean J Neurogastroenterol Motil.
  • 2008 Dec;14(2):88-95.
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) can be diagnosed by symptoms, endoscopic findings, and pH monitoring. Endoscopic findings and pH monitoring have high specificity and low sensitivity. Since medical fees for...
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Esophageal Baseline Impedance Reflects Mucosal Integrity and Predicts Symptomatic Outcome With Proton Pump Inhibitor Treatment

Xie C, Sifrim D, Li Y, Chen M, Xiao Y

  • KMID: 2417271
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):43-50.
  • doi: 10.5056/jnm17032
BACKGROUND/AIMS: Esophageal baseline impedance, which is decreased in gastroesophageal reflux disease (GERD) patients, is related to the severity of acid reflux and the integrity of the esophageal mucosa. The study...
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Trend in the Eradication Rates of Helicobacter pylori Infection Over the Last 10 Years in West Gyeonggi-do, Korea: A Single Center Experience

Park JS, Park JE, Oh BS, Yoon BW, Kim HK, Lee JW, Kim NH, Cho WS, Woo YS, Jahng J, Kim YS

BACKGROUND/AIMS: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of...
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Trends in the Eradication Rates of Helicobacter pylori Infection in Daegu and Gyeongsangbuk-do, Korea: Multicenter Study over 13 Years

Jung YS, Lee SH, Park CS, Oh MJ, Kim KO, Jang BI, Jeon SW, Jung MK, Park KS, Kim ES, Cho KB, Jung JT, Kwon JG, Kim EY, Kim WJ, Yang CH

BACKGROUND/AIMS: The eradication rates of Helicobacter pylori infection have been reported to have decreased over the years due to antibiotics resistance. The aim of this study is to investigate the...
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