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Alterations in the carnitine metabolism in epileptic children treated with valproic acid

Chung S, Choi J, Hyun T, Rha Y, Bae C

Serum concentrations of total carnitine, free carnitine and acylcarnitine were measured in forty-one epileptic patients treated with valproic acid (VPA). Among them, 14 patients were on VPA monotherapy and...
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Pharmacokinetic comparison of two valproic acid formulations: a plain and a controlled release enteric-coated tablets

Rha JH, Jang IJ, Lee KH, Chong WS, Shin SG, Lee N, Myung HJ

We investigated the single- and multiple dose pharmacokinetics of a new controlled-release formulation (Orfil retard enteric coated tablet) of valproic acid in comparison with those of the plain tablet as...
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