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Prognostic Factors for Absence Epilepsy in Childhood

Kang SY, Koo CM, Kim SH, Kim HD, Lee JS, Kang HC

PURPOSE: Childhood absence epilepsy (CAE) is a common form of idiopathic generalized epilepsy with onset middle childhood and has typically a good prognosis, but remission rates vary. We aimed to...
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Treatment Outcomes of Vagus Nerve Stimulation in Lennox-Gastaut Syndrome

Kang BS, Woo YS, Lee J, Yi YY, Koo BS, Kang JW

PURPOSE: Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies and frequently patients with this syndrome respond poorly to antiepileptic drugs. The aim of this study was to...
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Prognostic Factors for Absence Epilepsy in Childhood

Kang SY, Koo CM, Kim SH, Kim HD, Lee JS, Kang HC

PURPOSE: Childhood absence epilepsy (CAE) is a common form of idiopathic generalized epilepsy with onset middle childhood and has typically a good prognosis, but remission rates vary. We aimed to...
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Treatment Outcomes of Vagus Nerve Stimulation in Lennox-Gastaut Syndrome

Kang BS, Woo YS, Lee J, Yi YY, Koo BS, Kang JW

PURPOSE: Lennox-Gastaut syndrome (LGS) is one of the most severe epileptic encephalopathies and frequently patients with this syndrome respond poorly to antiepileptic drugs. The aim of this study was to...
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Distinct Topographical Patterns of Spike-Wave Discharge in Transgenic and Pharmacologically Induced Absence Seizure Models

Lee S, Hwang E, Lee M, Choi JH

Absence seizures (AS) are generalized non-convulsive seizures characterized by a brief loss of consciousness and spike-and-wave discharges (SWD) in an electroencephalogram (EEG). A number of animal models have been developed...
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Diagnostic Challenges Associated with GLUT1 Deficiency: Phenotypic Variabilities and Evolving Clinical Features

Kim H, Lee JS, Lee Y, Kim SY, Lim BC, Kim KJ, Choi M, Chae JH

GLUT1 deficiency is a rare neurometabolic disorder that can be effectively treated with ketogenic diet. However, this condition is underdiagnosed due to its nonspecific, overlapping, and evolving symptoms with age....
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Transient Abnormalities on Magnetic Resonance Imaging after Absence Seizures

Yoo HW, Yoon L, Kim HY, Kwak MJ, Park KH, Bae MH, Lee Y, Nam SO, Kim YM

Magnetic resonance imaging (MRI) is recommended for patients with epileptic seizures to rule out an underlying focal lesion. However, abnormalities in idiopathic generalized epilepsy, including childhood absence epilepsy, cannot usually...
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A Case of Ethosuximide-Induced Aplastic Anemia Successfully Treated with Methylprednisolone Pulse Therapy

Kang HS, Kim SH

Aplastic anemia may develop secondary to environmental exposure to entities such as chemicals, medical drugs, and infectious agents. Fatal complications from antiepileptic medications may occur despite careful and appropriate use....
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The Mechanism of Anti-Epileptogenesis by Levetiracetam Treatment is Similar to the Spontaneous Recovery of Idiopathic Generalized Epilepsy during Adolescence

Kikuyama H, Hanaoka T, Kanazawa T, Yoshida Y, Mizuno T, Toyoda H, Yoneda H

OBJECTIVE: The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant...
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Therapeutic Outcomes and Prognostic Factors in Childhood Absence Epilepsy

Kim HR, Kim GH, Eun SH, Eun BL, Byeon JH

BACKGROUND AND PURPOSE: Childhood absence epilepsy (CAE) is one of the most common types of pediatric epilepsy. It is generally treated with ethosuximide (ESM), valproic acid (VPA), or lamotrigine (LTG),...
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Outcomes of the Monoconversion to Valproate or Lamotrigine for Absence Seizures

Bin JH, Park SY, Han JY, Eom TH, Kim SJ, Kim YH, Lee IG, Chung SY

  • KMID: 2329262
  • J Korean Child Neurol Soc.
  • 2014 Jun;22(2):69-71.
PURPOSE: Ethosuximide (ESX) is currently not available due to various reasons in Korea. The aim of this study is to compare the efficacy of valproate (VPA) and lamotrigine (LTG) when...
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SPECT Findings in Association with Interictal and Ictal Discharges in a Patient with Jeavons Syndrome

Kim J, Chang JW, Kim JH

  • KMID: 2008769
  • J Korean Epilepsy Soc.
  • 2012 Jun;16(1):26-29.
Jeavons syndrome is one of the underrecognized epileptic syndromes, characterized by eyelid myoclonia with or without absence seizures, eye closure-induced seizures, electroencephalography (EEG) paroxysms, and photosensitivity. This syndrome is considered...
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Mutation Screening of the gamma-Aminobutyric Acid Type-A Receptor Subunit gamma2 Gene in Korean Patients with Childhood Absence Epilepsy

Kim YO, Kim MK, Nam TS, Jang SY, Park KW, Kim EY, Rho YI, Woo YJ

BACKGROUND AND PURPOSE: Since the gamma-aminobutyric acid type-A receptor subunit gamma2 gene (GABRG2) mutation was discovered in an Australian family with childhood absence epilepsy (CAE) and febrile convulsions, a few...
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Lamotrigine as a First-line Monotherapy in Children with Absence Seizures

Lee JY, Yum MS, Kim EH, Lee EH, Ko TS

  • KMID: 1442114
  • J Korean Child Neurol Soc.
  • 2011 Aug;19(2):142-149.
PURPOSE: Typical absence seizures are characterized by the daily presentation of frequent staring and typical 3Hz spike and wave discharges in otherwise healthy children. Typical absence seizures can present in...
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Predictive Factors for Valproate Treatment in Childhood Absence Epilepsy

Chi GH, Hwang TG

  • KMID: 2329440
  • J Korean Child Neurol Soc.
  • 2010 May;18(1):7-13.
PURPOSE: To determine the clinical and demographic factors associated with long-term remission of valproate(VPA) therapy in childhood absence epilepsy. METHODS: Fifty-six cases of childhood and juvenile absence epilepsy were identified by...
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Clinical efficacy and safety of lamotrigine monotherapy in newly diagnosed pediatric patients with epilepsy

Han JH, Oh JE, Kim SJ

PURPOSE: To verify the efficacy and safety of lamotrigine (LTG) monotherapy in newly diagnosed children with epilepsy. METHODS: We prospectively enrolled 148 children who had undergone LTG monotherapy at our institution...
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Single Nucleotide Polymorphisms of GABRG2 in Idiopathic Generalized Epilepsies(IGEs)

Yeon YH, Seung SJ, Hwang HS, Kim E, Kim YH, Lee IG, Chung SY

  • KMID: 2329513
  • J Korean Child Neurol Soc.
  • 2007 Nov;15(2):148-153.
PURPOSE: Mutations in gamma-aminobutyric acid(GABA) A receptor gamma2 subunit gene (GABRG2) were independently identified in families of generalized epilepsy with febrile seizures plus(GEFS+) and families of absence epilepsy and febrile...
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The Clinical and Electroencephalographic Characteristics of Hypomotor Seizures in Children

Hwang H, Choi JE, Chae JH, Kim KJ, Hwang YS

  • KMID: 2329340
  • J Korean Child Neurol Soc.
  • 2006 May;14(1):59-67.
PURPOSE: A hypomotor seizure is a useful descriptive terminology, but its clinical and ictal characteristics are not fully understood. We investigated the clinical and electrophysiological characteristics of hypomotor seizures in...
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The Pharmacological Treatment of Pediatric Onset Idiopathic Generalized Epilepsies: The Therapeutic Effects of Topiramate, Lamotrigine, and Valproate

Yum MS, You SJ, Kim DS, Ko TS

  • KMID: 2008747
  • J Korean Epilepsy Soc.
  • 2006 Dec;10(2):133-138.
PURPOSE: The majority of patients with idiopathic generalized epilepsy (IGE) are controlled by an antiepileptic drug when appropriately selected. So far, valproate is regarded as the first-line treatment for IGE....
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Concomitant Absence and Occipital Lobe Epilepsy in an Adolescent

Yun SH, Shin JH, Lee JH, Kim WK, Song HK

  • KMID: 2185358
  • J Korean Neurol Assoc.
  • 2005 Aug;23(4):551-553.
The incidence of absence and occipital lobe epilepsy appearing in the same young individual is quite rare. A fourteen year-old girl has had two types of recurrent seizures: 1)simple partial...
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