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Effect of Recombinant Human Epidermal Growth Factor Against Cutaneous Scar Formation in Murine Full-thickness Wound Healing

Kim YS, Lew DH, Tark KC, Rah DK, Hong JP

A visible cutaneous scar develops from the excess formation of immature collagen in response to an inflammatory reaction. This study examined the role of epidermal growth factor (EGF) in the...
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Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity

Song M, Kim MJ, Ha S, Park JB, Ryu SH, Suh PG

  • KMID: 1056227
  • Exp Mol Med.
  • 2005 Jun;37(3):161-168.
Phospholipase C-gamma1, containing two SH2 and one SH3 domains which participate in the interaction between signaling molecules, plays a significant role in the growth factor-induced signal transduction. However, the role...
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Effect of beta-mercaptoethanol or epidermal growth factor supplementation on in vitro maturation of canine oocytes collected from dogs with different stages of the estrus cycle

Kim MK, Fibrianto , Oh HJ, Jang G, Kim HJ, Lee KS, Kang SK, Lee BC, Hwang WS

  • KMID: 1099840
  • J Vet Sci.
  • 2004 Sep;5(3):253-258.
Supplementation of beta-mercaptoethanol (beta-ME) in in vitro maturation (IVM) medium was shown to improve embryo development and quality in several species. Epidermal growth factor (EGF) was also shown to improve...
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Akt is involved in the inhibition of cell proliferation by EGF

Jeon SH, Jeong WJ, Cho JY, Lee KH, Choi KY

  • KMID: 756072
  • Exp Mol Med.
  • 2007 Aug;39(4):491-498.
Axin is a negative regulator of the Wnt/beta-catenin pathway and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways...
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A double point mutation in PCL-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation

Chung SH, Kim SK, Kim JK, Yang YR, Suh PG, Chang JS

Growth factor stimulation induces Y783 phosphorylation of phosphoinositide-specific PLC-gamma1, and the subsequent activation of this enzyme in a cellular signaling cascade. Previously, we showed that a double point mutation, Y509A/F510A,...
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