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Comparison of enzyme and DNA analysis in a Tay-Sachs disease carrier screening program

Yoo HW, Astrin KH, Desnick RJ

Tay-Sachs disease (GM2 gangliosidosis, type 1; TSD) is an autosomal recessive GM2 gangliosidosis resulting from the deficient activity of the lysosomal hydrolase beta-hexosaminidase A (Hex A). With a carrier frequency...
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The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test

Kim YC, Kim JH, Cheung DY, Kim TH, Jun EJ, Oh JW, Kim CW, Chung WC, Kim BW, Kim SS, Kim JI, Park SH, Kim JK

BACKGROUND/AIMS: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK)...
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HBV DNA Levels, Aminotransferase and Histological Activity in Young Male Patients with HBeAg Positive Chronic Hepatitis B

Cho SC, Lee SH, Shinn JJ, Han SH, Roh BJ, Sohn JH, Lee DH, Kee CS

  • KMID: 863067
  • Korean J Hepatol.
  • 2002 Mar;8(1):44-51.
BACKGROUND/AIM: A significant correlation between HBV DNA and liver damage was found in precore mutant strains but there was no significant association between viral replication and liver damage in HBeAg...
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Early monitoring for detection of antituberculous drug-induced hepatotoxicity

Lee CM, Lee SS, Lee JM, Cho HC, Kim WS, Kim HJ, Ha CY, Kim HJ, Kim TH, Jung WT, Lee OJ

BACKGROUND/AIMS: We investigated the time of onset of antituberculous drug-induced hepatotoxicity (ADIH) and related characteristics. METHODS: Adult patients (n = 1,031) treated with first-line antituberculous drugs between February 2009 and January...
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Comparison of the 13C-urea breath test and the endoscopic phenol red mucosal pH test in the quantification of Helicobacter pylori infection loading

Cho YS, Chae HS, Jang SN, Kim JS, Son HS, Kim HK, Kim BW, Han SW, Choi KY, Lee HK, Chang ED

BACKGROUND/AIMS: The 13C-urea breath test (UBT) is a semiquantitative test for measuring Helicobacter pylori infection loading. H. pylori produces ammonia, which elevates the pH of the gastric mucosa and...
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Outcome of Pandemic H1N1 Pneumonia: Clinical and Radiological Findings for Severity Assessment

Cho WH, Kim YS, Jeon DS, Kim JE, Kim KI, Seol HY, Kim KU, Park HK, Lee MK, Park SK, Jeong YJ

BACKGROUND/AIMS: Pandemic influenza A (H1N1) virus infection presents with variable severity. However, little is known about clinical predictors of disease severity. We studied the clinical predictors of severe pandemic H1N1...
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