- Measurement of Human Cytochrome P450 Enzyme Induction Based on Mesalazine and Mosapride Citrate Treatments Using a Luminescent Assay
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Kim YH, Bae YJ, Kim HS, Cha HJ, Yun JS, Shin JS, Seong WK, Lee YM, Han KM
- KMID: 2380299
- Biomol Ther.
- 2015 Sep;23(5):486-492.
- doi: 10.4062/biomolther.2015.041
Drug metabolism mostly occurs in the liver. Cytochrome P450 (CYP) is a drug-metabolizing enzyme that is responsible for many important drug metabolism reactions. Recently, the US FDA and EU EMA... -
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- Dexamethasone differentiates NG108-15 cells through cyclooxygenase1 induction
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Kim HS, Song M, Kim E, Ryu SH, Suh PG
- KMID: 1094702
- Exp Mol Med.
- 2003 Jun;35(3):203-210.
Cyclooxygenase (COX) is a key enzyme in the conversion of arachidonic acid into prostanoids which participate in various cellular functions including apoptosis, mitogenesis, inflammation, immune modulation and differentiation. Moreover, the... -
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- Induction of hepatic ATP-citrate lyase by insulin in diabetic rat--effects of insulin on the contents of enzyme and its mRNA in cytosol, and the transcriptional activity in nuclei
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Park SW, Kim KS, Whang SK, Kim JS, Kim YS
- KMID: 1381214
- Yonsei Med J.
- 1994 Mar;35(1):25-33.
- doi: 10.3349/ymj.1994.35.1.25
The effects of insulin on ATP-citrate lyase, its mRNA in cytosol, and the transcriptional activity in nuclei of diabetic rat liver were studied. Experimental diabetes was induced by an intraperitoneal... -
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- Effects of Antiepileptic Drugs on Thyroid Hormones and Lipid Profiles
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Park SW, Cho YW, Yi HA, Sohn SI, Lee H, Lim JG, Yi SD
- KMID: 1640568
- J Korean Epilepsy Soc.
- 2004 Dec;8(2):132-137.
PURPOSE: It is known that serum thyroid hormones and lipid profiles are affected by the different biotransformation pathways of antiepileptic drugs (AEDs). The aim of this study was to evaluate... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Retinoic acid inhibits inducible nitric oxide synthase expression in 3T3-L1 adipocytes
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Yang JY, Koo BS, Kang MK, Rho HW, Sohn HS, Jhee EC, Park JW
- KMID: 755207
- Exp Mol Med.
- 2002 Nov;34(5):353-360.
The present study was undertaken to explore whether retinoids, which are known to have immunomodulatory actions, could attenuate tumor necrosis factor-alpha (TNF)-stimulated inducible nitric oxide synthase (iNOS) expression in 3T3-L1... -
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- Modulation of transglutaminase expression in rat skeletal muscle by induction of atrophy and endurance training
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Park SC, Kim WH, Lee MC, Seong SC, Song KY, Choe MA
- KMID: 644841
- J Korean Med Sci.
- 1994 Dec;9(6):490-496.
- doi: 10.3346/jkms.1994.9.6.490
The persistence of muscle fiber number regardless of size reduction in muscle atrophy has not yet been fully explained. For the mechanism inherent in skeletal muscle tissues for preventing cellular... -
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- Probable Case of Neuroleptic Malignant Syndrome Following Administration of Antituberculotic Drugs in a Chlorpromazine-Treated Patient
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Shim G, Kang DH, Kwon JS
- KMID: 1785840
- J Korean Med Sci.
- 2008 Aug;23(4):734-736.
- doi: 10.3346/jkms.2008.23.4.734
Neuroleptic malignant syndrome (NMS), a potentially fatal adverse reaction to neuroleptics, is known to occur more often in the initial stage of antipsychotic treatment. We describe a patient with chronic... -
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- Induction of nitric oxid esynthase(NOS) by soluble glucocorticoid induced tumor necrosis factor receptor(sGITR) is modulated by IFN-g in murine macrophage
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Shin HH, Lee HW, Choi HS
- KMID: 1094698
- Exp Mol Med.
- 2003 Jun;35(3):175-180.
Earlier study showed that glucocorticoid induced tumor necrosis factor receptor (GITR), a new TNFR family, activated murine macrophages to express inducible nitric oxide synthase (iNOS) and to generate nitric oxide... -
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- The Pharmacokinetic Interaction and Therapeutic Plasma Concentration of Oxcarvazepine
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Kang JK, Yang HO, Park SY, Jeong YH, Kwak KH, Lee SA
- KMID: 1816453
- J Korean Epilepsy Soc.
- 1999 Dec;3(2):200-205.
PURPOSE: Oxcarbazepine (OXC) is chemically related to carbamazepine (CBZ). OZC exerts less liver enzyme induction than CBZ and is completely metabolized by reduction to the active metabolite, 10, 11-dihydro-10-hydroxy-5H-dibenzo (b,f)... -
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- Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
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Kim SY, Kang HT, Choi HR, Park SC
- KMID: 991619
- Exp Mol Med.
- 2011 Jan;43(1):15-23.
- doi: 10.3858/emm.2011.43.1.002
Biliverdin reductase A (BLVRA), an enzyme that converts biliverdin to bilirubin, has recently emerged as a key regulator of the cellular redox cycle. However, the role of BLVRA in the... -
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- Hydrogen peroxide mediates doxorubicin-induced transglutaminase 2 expression in PC-14 human lung cancer cell line
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Han JA, Park SC
- KMID: 1029936
- Exp Mol Med.
- 1999 Jun;31(2):83-88.
Increased expression of Transglutaminases 2 (TGase 2, TGase C) was observed in PC-14 human lung cancer cells in association with doxorubicin resistance and the reduction of the enzyme expression was correlated with... -
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- Antimutagenic and Antioxidant Activities of Thai Rice Brans
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Insuan O, Chariyakornkul A, Rungrote Y, Wongpoomchai R
- KMID: 2400772
- J Cancer Prev.
- 2017 Jun;22(2):89-97.
- doi: 10.15430/JCP.2017.22.2.89
BACKGROUND: Rice bran is the outer layer of the rice grain, and contains high amounts of bioactive phytochemicals. Here, we investigated and compared chemopreventive properties of purple and white rice... -
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- Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro
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Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK
- KMID: 1081463
- Exp Mol Med.
- 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and... -
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- CYP1A2 activity as a risk factor for bladder cancer
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Lee SW, Jang IJ, Shin SG, Lee KH, Yim DS, Kim SW, Oh SJ, Lee SH
- KMID: 644840
- J Korean Med Sci.
- 1994 Dec;9(6):482-489.
- doi: 10.3346/jkms.1994.9.6.482
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer and 84 control subjects from measurements of theophylline, metoprolol and isoniazid and their metabolites in urine, respectively.... -
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- Toll-like receptor 9 dependent activation of MAPK and NF-kB is required for the CpG ODN-induced matrix metalloproteinase-9 expression
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Lim EJ, Lee SH, Lee JG, Kim JR, Yun SS, Baek SH, Lee C
- KMID: 1094665
- Exp Mol Med.
- 2007 Apr;39(2):239-245.
Unmethylated CpG oligodeoxynucleotides (CpG ODNs) activate immune cells to produce immune mediators. This study demonstrates that in murine macrophage RAW 264.7 cells, CpG ODN-mediated matrix metalloproteinase-9 (MMP-9) expression is regulated... -
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- Decreased nitric oxide synthesis in rats with chronic renal failure
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Kim SW, Lee JU, Paek YW, Kang DG, Choi KC
- KMID: 1730639
- J Korean Med Sci.
- 2000 Aug;15(4):425-430.
- doi: 10.3346/jkms.2000.15.4.425
The present study was aimed at investigating whether an altered role of nitric oxide (NO) is involved in chronic renal failure (CRF). Rats were subjected to 5/6 nephrectomy and kept... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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- Up-regulation of defense enzymes is responsible for low reactive oxygen species in malignant prostate cancer cells
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Lim HW, Hong S, Jin W, Lim S, Kim SJ, Kang HJ, Park EH, Ahn K, Lim CJ
- KMID: 1089461
- Exp Mol Med.
- 2005 Oct;37(5):497-506.
Reactive oxygen species (ROS) are involved in a diversity of important phenomena in the process of tumor development. To investigate the alterations of oxidative stress and their related systems in... -
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- Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappa B pathway in human dermal fibroblasts
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Lee YR, Noh EM, Jeong EY, Yun SK, Jeong YJ, Kim JH, Kwon KB, Kim BS, Lee SH, Park CS, Kim JS
- KMID: 1119320
- Exp Mol Med.
- 2009 Aug;41(8):548-554.
- doi: 10.3858/emm.2009.41.8.060
Cordycepin (3'-deoxyadenosine) has been shown to exhibit many pharmacological activities, including anti-cancer, anti-inflammatory, and anti-infection activities. However, the anti-skin photoaging effects of cordycepin have not yet been reported. In the... -
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