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The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes

Park EJ, Chang JH, Kim JS, Yum JS, Chung SI

  • KMID: 1109305
  • Exp Mol Med.
  • 2000 Jun;32(2):72-78.
Escherichia coli heat-labile enterotoxin (LT), which causes a characteristic diarrhea in humans and animals, is a strong mucosal immunogen and has powerful mucosal adjuvant activity towards coadministered unrelated antigens. Here...
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Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin

Park EJ, Chang JH, Kim JS, Chung SI, Yum JS

  • KMID: 1029939
  • Exp Mol Med.
  • 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine...
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Equine hyperimmune serum protects mice against Clostridium difficile spore challenge

Yan W, Shin KS, Wang SJ, Xiang H, Divers T, McDonough , Bowman J, Rowlands A, Akey B, Mohamed H, Chang YF

Clostridium (C.) difficile is a common cause of nosocomial diarrhea in horses. Vancomycin and metronidazole have been used as standard treatments but are only moderately effective, which highlights the need...
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Clinical features of elderly chronic urticaria

Ban GY, Kim MY, Yoo HS, Nahm DH, Ye YM, Shin YS, Park HS

BACKGROUND/AIMS: Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it is essential to identify the specific features of this...
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