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Is Clostridium difficile infection a real threat in patients with ulcerative colitis? A prospective, multicenter study in Korea

Kim DB, Lee KM, Park SH, Kim YS, Kim ES, Lee J, Jung SA, Seo GS, Lee JM

BACKGROUND/AIMS: Clostridium difficile infection (CDI) has been reported to be a cause of flare-ups in patients with ulcerative colitis (UC). We evaluated the prevalence and clinical outcomes of CDI in...
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Comparison and Evaluation of Diagnostic Assays for Clostridium difficile Infection

Kim KB, Kim DH, Lee W, Ha JS, Ryoo NH, Jeon DS, Kim JR

BACKGROUND: Clostridium difficile is a leading causative microorganism of pseudomembranous colitis (PMC) and antibiotic-associated diarrhea. In patients who have a history of antibiotic use and diarrhea, the presence of the...
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Fecal Calprotectin Level Reflects the Severity of Clostridium difficile Infection

Kim J, Kim H, Oh HJ, Kim HS, Hwang YJ, Yong D, Jeong SH, Lee K

Clostridium difficile is a significant nosocomial and community-acquired pathogen, and is the leading cause of antibiotic-induced diarrhea associated with high morbidity and mortality. Given that the treatment outcome depends on...
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Milk-alkali syndrome secondary to the intake of calcium supplements

Lee IH, Noh SY, Kang GW

Milk-alkali syndrome (MAS), a triad of hypercalcemia, metabolic alkalosis, and renal failure, is associated with ingestion of large amounts of calcium and absorbable alkali. MAS is the third most common...
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Incidence and Clinical Outcomes of Clostridium difficile Infection after Treatment with Tuberculosis Medication

Lee YM, Huh KC, Yoon SM, Jang BI, Shin JE, Koo HS, Jung Y, Kim SH, Moon HS, Lee SW, Daejeon-Chungchung Intestinal Research Group

BACKGROUND/AIMS: To determine the incidence and clinical characteristics of tuberculosis (TB) medication-associated Clostridium difficile infection. METHODS: This multicenter study included patients from eight tertiary hospitals enrolled from 2008 to 2013. A...
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Comparison of Histamine 2 Receptor Antagonists and Proton Pump Inhibitors on Infectious Complications in Critically Ill Patients

Park SY, Choi JH, Youn YJ, Rhie SJ

BACKGROUND: The use of acid suppressive agents became a standard therapy in an intensive care unit (ICU) to prevent stress related gastrointestinal mucosal damage. However, the risk of infectious diseases...
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Clinical Characterization of Clostridium difficile Infection in Elderly Patients

Jeon SR

No abstract available.
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Advanced chronic kidney disease: a strong risk factor for Clostridium difficile infection

Kim SC, Seo MY, Lee JY, Kim KT, Cho E, Kim MG, Jo SK, Cho WY, Kim HK

BACKGROUND/AIMS: It has been suggested that chronic kidney disease (CKD) is a risk factor for Clostridium difficile infection (CDI) and is associated with increased mortality among patients infected with C....
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Refractory pseudomembranous colitis that was treated successfully with colonoscopic fecal microbial transplantation

Shin JY, Ko EJ, Lee SH, Shin JB, Kim SI, Kwon KS, Kim HG, Shin YW, Bang BW

Pseudomembranous colitis (PMC) is a nosocomial and opportunistic infection caused by Clostridium difficile. PMC is related to the use of antibiotics leading to intestinal dysbiosis and an overgrowth of C....
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A Case of Toxic Megacolon Caused by Clostridium difficile Infection and Treated with Fecal Microbiota Transplantation

Gweon TG, Lee KJ, Kang D, Park SS, Kim KH, Seong H, Ban TH, Moon SJ, Kim JS, Kim SW

Toxic megacolon is a rare clinical complication of fulminant Clostridium difficile infection. The mortality rate of fulminant C. difficile infection is reported to be as high as 50%. Fecal microbiota...
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Pseudomembranous Colitis: A Complicated Case with Transient Increase of Carcinoembryonic Antigen

Nam DI, Kang C, Jung IH, Moon HG, Youn BR, Lee NH

Pseudomembranous colitis (PMC) is a frequent cause of morbidity and mortality among hospitalized patients. Although diarrhea is the most common manifestation, PMC may be associated with intraperitoneal fluid accumulation in...
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Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient

Jang MO, An JH, Jung SI, Park KH

The rates and severity of Clostridium difficile infections, including pseudomembranous colitis, have increased markedly. However, there are few effective treatments for refractory or recurrent C. difficile infections and the outcomes...
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Adverse Drug Reactions of Long-term Intravenous Antibiotics in Patients with Pyogenic Spondylitis

Kim DH, Kim HS, Nam KH, Choi BK, Han IH

OBJECTIVE: The purpose of this study was to investigate the incidence, cause, and influence of the adverse drug reactions (ADRs) associated with long-term intravenous antibiotics in patients with pyogenic spondylitis...
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A case of pseudomembranous colitis associated with antituberculosis therapy in a patient with tuberculous meningitis

Kim MJ, Jeong HW, Choi YR

  • KMID: 2168989
  • J Biomed Res.
  • 2014 Mar;15(1):44-48.
Pseudomembranous colitis (PMC) is known to be associated with the long-term administration of antibiotics, which alter normal gastrointestinal flora and allow overgrowth of Clostridium difficile. However, antituberculosis agents are rarely...
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Rectal Prolapse Complicated withC lostridium difficile-associated Pseudomembranous Colitis in a Child

Lee MS, Kim JS

Among the complications of Clostridium difficile (C. difficile) infection, rectal prolapse has been very rarely reported in children. We report a 29-month-old girl who presented with rectal prolapse complicated with...
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Comparison of ChromID Agar and Clostridium difficile Selective Agar for Effective Isolation of C. difficile from Stool Specimens

Shin BM, Lee EJ

BACKGROUND: ChromID Clostridium difficile agar (IDCd; bioMerieux SA, France) is a recently developed chromogenic medium for rapid and specific isolation of C. difficile. We compared the performance of IDCd with...
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The Simple Predictors of Pseudomembranous Colitis in Patients with Hospital-Acquired Diarrhea: A Prospective Observational Study

Yang BK, Do BJ, Kim EJ, Lee JU, Kim MH, Kang JG, Kim HS, Kim KH, Jang MK, Lee JH, Kim HY, Shin WG

  • KMID: 1774527
  • Gut Liver.
  • 2014 Jan;8(1):41-48.
BACKGROUND/AIMS: As the incidence rate of and mortality from pseudomembranous colitis (PMC) are increasing worldwide, it is important to study the simple predictive risk factors for PMC among patients with...
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The Intestinal Microbiota and Human Disease

Ko JS

Advances in sequencing technology and the development of metagenomics have opened up new ways to investigate the microorganisms inhabiting the human gut. The intestinal microbiota confer protection against pathogens, contribute...
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A Case of Clostridium difficile Bacteremia in a Patient with Loop Ileostomy

Choi JL, Kim BR, Kim JE, Woo KS, Kim KH, Kim JM, Lee SE, Han JY

Clostridium difficile, an anaerobic, spore-forming, gram-positive, rod-shaped bacterium, is the most common nosocomial pathogen causing pseudomembranous colitis. C. difficile is not intrinsically invasive and rarely infects extraintestinal sites. The bacterium,...
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Two Cases of Refractory Pseudomembranous Colitis that Healed Following Fecal Microbiota Transplantation

Gweon TG, Choi MG, Lee SK, Ha JH, Kim EY, Go BS, Kim SW

The incidence, recurrence, and mortality of Clostridium difficile infection are increasing and the standard therapy is oral metronidazole or vancomycin. Since treatment failure with standard therapy is increasing, an alternative...
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