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Expression of µ-Opioid Receptor in CA1 Hippocampal Astrocytes

Nam MH, Han KS, Lee J, Bae JY, An H, Park S, Oh SJ, Kim E, Hwang E, Bae YC, Lee CJ

µ-opioid receptor (MOR) is a class of opioid receptors with a high affinity for enkephalins and beta-endorphin. In hippocampus, activation of MOR is known to enhance the neuronal excitability of...
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The Effects of Pre-emptive Administration of Ketamine and norBNI on Pain Behavior, c-Fos, and Prodynorphin Protein Expression in the Rat Spinal Cord after Formalin-induced Pain Is Modulated by the DREAM Protein

Long I, Suppian R, Ismail Z

BACKGROUND: We investigated the effects of pre-emptive administration of ketamine and norBNI on pain behavior and the expression of DREAM, c-Fos, and prodynorphin proteins on the ipsilateral side of the...
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The Neuroprotective Effect of delta-opioid Receptor Stimulation with [D-Ala2, D-Leu5] Enkephalin Against Ischemic Neuronal Injury

Kim H, Lee SW, Park JS, Min JH, Min MK

  • KMID: 2333069
  • J Korean Soc Emerg Med.
  • 2012 Feb;23(1):111-119.
PURPOSE: Oxygen is indispensable for survival and aerobic metabolism in all mammalian cells. Inadequate oxygen triggers a multifaceted cellular response negatively impacting important physiological functions which are observed in clinical...
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Nerve Regeneration and Detrusor Contractility after Muscle Precursor Cells Implantation in Unilateral Pelvic Nerve Transected Rat

Im CM, Kwon DD, Ryu SB

  • KMID: 2294037
  • Korean J Urol.
  • 2005 Aug;46(8):861-866.
Purpose: Preliminary data suggest that muscle precursor cells (MPCs) play a role in the repair of injured tissues by responding to the release of unknown growth factors, which subsequently induce...
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Role of Protein kinase C in Desensitization of Somatostatin-induced Calcium Signalling in NG108-15 Cells

Kim KM, Sung JH, Kim MJ, Rhie DJ, Jo YH, Hahn SJ, Kim MS, Yoon SH, Kim BS

BACKGROUND: Activation of G-protein coupled-somatostatin receptors induces the release of calcium from inositol 1, 4, 5-trisphosphate-sensitive intracelluar stores. G-protein-coupled receptor signaling decreases with prolonged exposure to an agonist. SEBJECTS and...
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The Effects of Dopamin D-1 Agonist (SKF-38393) on Expression of Substance-P & Enkephalin mRNA in the Striatum of Hemiparkinsonian Rat Model

Lee SH, Kwon DY, Yu SW, Koh SB, Park MK, Kim H, Park KW, Lee DH

  • KMID: 2343065
  • J Korean Neurol Assoc.
  • 2003 Oct;21(5):527-533.
BACKGROUND: The selective D1 dopamine agonist has been known to play a stimulatory role in substance-P synthesis in the striatum, but its effect on the enkephalin mRNA expression has not...
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Genomic Changes in the Striatum of Unilateral 6-hydroxydopamine Lesioned Parkinson Rat Model

Kim BJ, Park KW, Kim H, Lee DH

  • KMID: 2342993
  • J Korean Neurol Assoc.
  • 2002 Jul;20(4):385-393.
BACKGROUND: Parkinson's disease is the primary degenerative disease characterized by rigidity, bradykinesia and resting tremor. Even though dopaminergic cell loss of the substantia nigra compacta is a main pathogenesis of...
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Pain-reducing Effect by Transplants of Isolated Xenogeneic Chromaffin Cells in Mouse

Han YM, Lee JP, Hwang HS, Song JH, Park SK, Park SJ, Jin JK, Choi EK, Kim YS, Ahn MS

  • KMID: 1955971
  • J Korean Neurosurg Soc.
  • 2001 Apr;30(4):417-424.
OBJECTIVE: Adrenal medullary chromaffin cells are known to release analgesic substances such as opioides and catecholamines. Transplantation of them is a novel method that challenges current approaches in treating...
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Inhibitory Mechanism of Periaqueductal Gray Matter on Neuropathic Pain in Rat

Kim BO, Ryu JW, Seo JS, Sohn JH

  • KMID: 2174649
  • J Korean Acad Rehabil Med.
  • 2001 Feb;25(1):110-116.
OBJECTIVE: Using Lee et al (1996) model, we assessed the effect of opioid within the PAG on the manifestations of the neuropathic pain, and we studied the effects of naloxone...
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Receptor Activation is Not the Main Rescue Mechanism of Morphine in Peroxynitrite-Induced Death of Human Neuroblastoma SH-SY5Y Cells

Son Y, Ahn JY, Choi YS, Song YK, Yoon JS, Kim TY, Cheong YP

BACKGROUND: In the present study, we examined the effect of morphine on NO- and peroxynitrite-induced cell death using a human neuroblastoma SH-SY5Y cell line which abundantly expresses micro, delta and...
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The Effects of Repeated Stress on the Opioidergic Neurotransmission in Rats

Sakong JK, Lee KH, Koo BH, Kim JS, Lee JB, Ha JH

  • KMID: 2340324
  • J Korean Neuropsychiatr Assoc.
  • 1999 May;38(3):638-646.
OBJECTIVES: Research into emotional or behavioral stress typically focuses upon the hypothalamic-pituitary-adrenal axis. It is well established that the hypothalamic-pituitary-adrenocortical axis is subject to inhibitory control by opioids in...
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Effects of Intrathecal Transmitters on the Pain-induced Micturition Reflex

Park JS, Kim DY, Ahn DK

  • KMID: 2290149
  • Korean J Urol.
  • 1998 Aug;39(8):729-736.
PURPOSE: Irritations or painful stimuli to the bladde: may alter voiding behaviorand this may be associated with dysfunction of periurethral muscles. In our study, recording of bladder and sphincter activity...
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The Effect of Intrastriatal 6-Hydroxydopamine injection on the Expression of Neurotrophic factors in the Rat Brain

Kim BJ, Kim H, Lee DH

  • KMID: 2342638
  • J Korean Neurol Assoc.
  • 1998 Apr;16(2):131-142.
BACKGROUND AND PURPOSE: Neurotrophic factors has been a subject of interest in the research of Parkinson's disease. In this experiment, intrastriatal 6-Hydroxydopamine(6-OHDA) injection was used to observe the effect of...
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Distribution of Neuropeptide mRNA-Containing Neurons and Changes of Their Gene Expression in the Rat Periaqueductal Gray in a Neuropathic Pain Model

Huh SM, Kim JG, Bae MA, Kim DS, Park MJ, Jo HJ

  • KMID: 1529457
  • Korean J Anat.
  • 1997 Jun;30(3):205-214.
The distribution of enkephalin, dynorphin, substance P and neurotensin in the periaqueductal gray[PAG] has been well established by immunohistochemical methods. However, there is little information about the regional distribution of...
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Effects of an Opiate Receptor Antagonist Naloxone on Endotoxic Shock and Tumorigenesis

Ha TY, Ko YS, Moon SR

  • KMID: 1547846
  • Korean J Immunol.
  • 1997 Mar;19(1):91-106.
Septic shock is one of the leading cause of death in hospitalized patients and mortality rates of up to 50 % have been reported. Despite all efforts, no regimen today...
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The Gene Expression of Dynorphin, Enkephalin, c-Fos in the Neuropathic Rat

Han NH, Lee WH, Hwang WJ, Yoon SH, Shin YS, Son SC, Kim HJ, Choi SJ, Lim K, Hwang BD

BACKGROUND: We studied the time course of gene expression of dynorphin, enkephalin, c-fos, and the changes of allodynia, and the effect of chemical sympathectomy on the gene expression and allodynia...
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The Effect of Unilateral Dopaminergic Deafferentation on Kainic acid Induced Seizures in the Rat

Park KW, Lee DH

  • KMID: 2066049
  • J Korean Neurol Assoc.
  • 1996 Mar;14(1):114-125.
There has been quite a number of research regarding the role of dopamine in epilepsy and it has been still very controversial, In this study, the effect of dopaminergic deafferentation...
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The effects of kainate-induced Seizure on the Opioid Peptide Gene Expression in Rat Hippocampus

Park KW, Park MK, Kim BJ, Ko SB, Kang YH, Lee DH

  • KMID: 1957293
  • J Korean Neurol Assoc.
  • 1994 Dec;12(4):614-622.
In the rat hippocampal formation, the time-course and dose-response of the expression of enkephalin and dynorphin gene were examined after kainate (KA) treatment with in situ hybridization histochemistry. The KA...
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Changes of Neuropeptides in the Basal Ganglia of Hemiparkinsonian Rat Model

Park KW, Lee DH, Park MK, Kim BJ, Ko SB, Suh YS

  • KMID: 1957292
  • J Korean Neurol Assoc.
  • 1994 Dec;12(4):604-613.
We used in situ hybridization histochemistry with synthetic oligonucleotide probes to examined the effects of unilateral 6-hydroxydopamine lesions (which eliminated tyrosine hydroxylase mRNA containing cells in mesencephalon) on enkephalin, dynorphin,...
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Dynorphin and enkephalin mRNAs in the rat forebrain by in situ hynridization histochmistry

Lee MH, Suh YS

  • KMID: 1686711
  • Korean J Anat.
  • 1992 Jun;25(2):179-187.
No abstract available.
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