- Poly (ADP-Ribose) Polymerase immunoreactivity in Motor Neurons and Astrocytes in the Spinal Cord of Sporadic Amyotrophic Lateral Sclerosis Patients
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Kim SH, Henkel JS, Kim JH, Kim MH, Engelhardt JI, Siklos L, Kong G, Appel SH
- KMID: 2137971
- J Korean Neurol Assoc.
- 2002 Nov;20(6):668-681.
BACKGROUND: The evidence for increased oxidative stress and DNA damage in amyotrophic lateral sclerosis (ALS) prompted studies to determine if the expression of poly (ADP-ribose) polymerase (PARP) is increased in... -
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- Increased Neuronal and Glial Poly (ADP-Ribose) Polymerase Immunoreactivity in the Brain of Sporadic Amyotrophic Lateral Sclerosis
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Kim SH, Engelhardt JI, Kim JH, Kong G, Appel SH
- KMID: 2137972
- J Korean Neurol Assoc.
- 2002 Nov;20(6):682-693.
BACKGROUND: Over activation of the DNA repairing enzyme, poly (ADP-ribose) polymerase (PARP) in response to oxidative damage of DNA appears to play a role in cellular death in neurodegenerative diseases.... -
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