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26 results

Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice

Duan Q, Wang T, Zhang N, Perera V, Liang X, Abeysekera IR, Yao X

  • Endocrinol Metab.
  • 2016 Mar;31(1):174-184.
  • doi: 10.3803/EnM.2016.31.1.174
BACKGROUND: Increased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in...
Comparison of Fixed versus Calculated Activity of Radioiodine for the Treatment of Graves Disease in Adults

Canto AU, Dominguez , Jimeno CA, Obaldo JM, Ogbac RV

  • Endocrinol Metab.
  • 2016 Mar;31(1):168-173.
  • doi: 10.3803/EnM.2016.31.1.168
BACKGROUND: Radioactive iodine as a treatment modality has been shown in several studies to be a safe and effective therapy for Graves disease. However, there is still no uniformity regarding...
Effects of Dipeptidyl Peptidase-4 Inhibitors on Hyperglycemia and Blood Cyclosporine Levels in Renal Transplant Patients with Diabetes: A Pilot Study

Bae J, Lee MJ, Choe EY, Jung CH, Wang HJ, Kim MS, Kim YS, Park JY, Kang ES

  • Endocrinol Metab.
  • 2016 Mar;31(1):161-167.
  • doi: 10.3803/EnM.2016.31.1.161
BACKGROUND: The use of dipeptidyl peptidase-4 (DPP-4) inhibitors is increasing among renal transplant patients with diabetes. However, the glucose-lowering efficacies of various DPP-4 inhibitors and their effects on blood cyclosporine...
Recovery of Adrenal Function in Patients with Glucocorticoids Induced Secondary Adrenal Insufficiency

Baek JH, Kim SK, Jung JH, Hahm JR, Jung J

  • Endocrinol Metab.
  • 2016 Mar;31(1):153-160.
  • doi: 10.3803/EnM.2016.31.1.153
BACKGROUND: The chronic use of glucocorticoids (GC) suppresses function of the hypothalamic-pituitary-adrenal axis and often results in secondary adrenal insufficiency (AI). The present study aimed to determine the recovery rate...
Radiographic Characteristics of Adrenal Masses in Oncologic Patients

Lee JH, Kim EK, Hong AR, Roh E, Bae JH, Kim JH, Shin CS, Kim SY, Kim SW

  • Endocrinol Metab.
  • 2016 Mar;31(1):147-152.
  • doi: 10.3803/EnM.2016.31.1.147
BACKGROUND: We aimed to assess the usefulness of pre-contrast Hounsfield unit (HU) and mass size on computed tomography to differentiate adrenal mass found incidentally in oncologic patients. METHODS: From 2000 to...
Thyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease

Park S, Kim TY, Sim S, Lim S, Kim M, Kwon H, Jeon MJ, Kim WG, Shong YK, Kim WB

  • Endocrinol Metab.
  • 2016 Mar;31(1):142-146.
  • doi: 10.3803/EnM.2016.31.1.142
BACKGROUND: Thyrotoxic periodic paralysis (TPP) is a rare complication of thyrotoxicosis characterized by acute attacks of muscle weakness and hypokalemia. Recently, variation in several genes was suggested to be associated...
Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus

Suh S, Kim MY, Kim SK, Hur KY, Park MK, Kim DK, Cho NH, Lee MK

  • Endocrinol Metab.
  • 2016 Mar;31(1):134-141.
  • doi: 10.3803/EnM.2016.31.1.134
BACKGROUND: Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin...
Association of Waist-Height Ratio with Diabetes Risk: A 4-Year Longitudinal Retrospective Study

Son YJ, Kim J, Park HJ, Park SE, Park CY, Lee WY, Oh KW, Park SW, Rhee EJ

  • Endocrinol Metab.
  • 2016 Mar;31(1):127-133.
  • doi: 10.3803/EnM.2016.31.1.127
BACKGROUND: Waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of various baseline adiposity indices, including WHtR, with...
Effect of Pitavastatin Treatment on ApoB-48 and Lp-PLA2 in Patients with Metabolic Syndrome: Substudy of PROspective Comparative Clinical Study Evaluating the Efficacy and Safety of PITavastatin in Patients with Metabolic Syndrome

Lee HS, Jung CH, Kim SR, Jang HC, Park CY, PROPIT Study Team

  • Endocrinol Metab.
  • 2016 Mar;31(1):120-126.
  • doi: 10.3803/EnM.2016.31.1.120
BACKGROUND: Apolipoprotein (Apo) B-48 is an intestinally derived lipoprotein that is expected to be a marker for cardiovascular disease (CVD). Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a vascular-specific inflammatory marker and...
Risk Factors Associated with Disease Recurrence among Patients with Low-Risk Papillary Thyroid Cancer Treated at the University of the Philippines-Philippine General Hospital

Jauculan M, Buenaluz-Sedurante M, Jimeno CA

  • Endocrinol Metab.
  • 2016 Mar;31(1):113-119.
  • doi: 10.3803/EnM.2016.31.1.113
BACKGROUND: The management of papillary thyroid carcinoma (PTC) in high-risk patients is well-standardized. However, this is not the case for low-risk patients. Filipinos show a high incidence of recurrence of...
Prolonged Tp-e Interval, Tp-e/QT Ratio and Tp-e/QTc Ratio in Patients with Type 2 Diabetes Mellitus

Tokatli A, Kiliçaslan F, Alis M, Yiginer O, Uzun M

  • Endocrinol Metab.
  • 2016 Mar;31(1):105-112.
  • doi: 10.3803/EnM.2016.31.1.105
BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with increased risk of malignant ventricular arrhythmias. Cardiac electrical inhomogeneity may be the leading cause of the increased arrhythmic risk in patients...
Low Prevalence of Somatic TERT Promoter Mutations in Classic Papillary Thyroid Carcinoma

Jeon MJ, Kim WG, Sim S, Lim S, Kwon H, Kim TY, Shong YK, Kim WB

  • Endocrinol Metab.
  • 2016 Mar;31(1):100-104.
  • doi: 10.3803/EnM.2016.31.1.100
BACKGROUND: Transcriptional activating mutations of telomerase reverse transcriptase (TERT) are associated with more aggressive thyroid cancer. We evaluated the significance of TERT promoter mutations in Korean patients with classic papillary...
High Levels of Serum DPP-4 Activity Are Associated with Low Bone Mineral Density in Obese Postmenopausal Women

Kim SW, Cho EH

  • Endocrinol Metab.
  • 2016 Mar;31(1):93-99.
  • doi: 10.3803/EnM.2016.31.1.93
BACKGROUND: Dipeptidyl peptidase 4/CD26 (DPP-4) is a widely expressed cell surface serine protease. DPP-4 inhibitors, one of common anti-diabetic agents play a protective role in bone metabolism in recent studies....
The Relationship between 10-Year Cardiovascular Risk Calculated Using the Pooled Cohort Equation and the Severity of Non-Alcoholic Fatty Liver Disease

Lee JI, Kim MC, Moon BS, Song YS, Han EN, Lee HS, Son Y, Kim J, Han EJ, Park HJ, Park SE, Park CY, Lee WY, Oh KW, Park SW, Rhee EJ

  • Endocrinol Metab.
  • 2016 Mar;31(1):86-92.
  • doi: 10.3803/EnM.2016.31.1.86
BACKGROUND: We investigated the association between the severity of non-alcoholic fatty liver disease (NAFLD) and the estimated 10-year risk of cardiovascular disease (CVD) calculated by Pooled Cohort Equation (PCE) and...
Effects of Short-Term Exenatide Treatment on Regional Fat Distribution, Glycated Hemoglobin Levels, and Aortic Pulse Wave Velocity of Obese Type 2 Diabetes Mellitus Patients

Hong JY, Park KY, Kim BJ, Hwang WM, Kim DH, Lim DM

  • Endocrinol Metab.
  • 2016 Mar;31(1):80-85.
  • doi: 10.3803/EnM.2016.31.1.80
BACKGROUND: Most type 2 diabetes mellitus patients are obese and have obesity related vascular complications. Exenatide treatment is well known for both decreasing glycated hemoglobin levels and reduction in body...
Well-Differentiated Thyroid Cancer: The Philippine General Hospital Experience

Lo TE, Uy AT, Maningat P

  • Endocrinol Metab.
  • 2016 Mar;31(1):72-79.
  • doi: 10.3803/EnM.2016.31.1.72
BACKGROUND: Well-differentiated thyroid cancer (WDTC) is the most common form of thyroid malignancy. While it is typically associated with good prognosis, it may exhibit higher recurrence and mortality rates in...
Serum γ-Glutamyl Transferase Is Inversely Associated with Bone Mineral Density Independently of Alcohol Consumption

Choi HS, Kim KJ, Rhee Y, Lim SK

  • Endocrinol Metab.
  • 2016 Mar;31(1):64-71.
  • doi: 10.3803/EnM.2016.31.1.64
BACKGROUND: γ-Glutamyl transferase (GGT) is a well-known marker of chronic alcohol consumption or hepatobiliary diseases. A number of studies have demonstrated that serum levels of GGT are independently associated with...
Differentiated Thyroid Cancer in Asians

Kim BH

  • Endocrinol Metab.
  • 2016 Mar;31(1):62-63.
  • doi: 10.3803/EnM.2016.31.1.62
No abstract available.
Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4

Leem J, Lee IK

  • Endocrinol Metab.
  • 2016 Mar;31(1):52-61.
  • doi: 10.3803/EnM.2016.31.1.52
Vascular calcification, abnormal mineralization of the vessel wall, is frequently associated with aging, atherosclerosis, diabetes mellitus, and chronic kidney disease. Vascular calcification is a key risk factor for many adverse...
In Vivo Models for Incretin Research: From the Intestine to the Whole Body


  • Endocrinol Metab.
  • 2016 Mar;31(1):45-51.
  • doi: 10.3803/EnM.2016.31.1.45
Incretin hormones are produced by enteroendocrine cells (EECs) in the intestine in response to ingested nutrient stimuli. The incretin effect is defined as the difference in the insulin secretory response...

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