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Very small embryonic-like stem-cell optimization of isolation protocols: an update of molecular signatures and a review of current in vivo applications

Shin DM, Suszynska , Mierzejewska K, Ratajczak , Ratajczak

  • KMID: 2154275
  • Exp Mol Med.
  • 2013 Nov;45(11):e56.
As the theory of stem cell plasticity was first proposed, we have explored an alternative hypothesis for this phenomenon: namely that adult bone marrow (BM) and umbilical cord blood (UCB)...
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Roles of gangliosides in mouse embryogenesis and embryonic stem cell differentiation

Kwak DH, Seo BB, Chang KT, Choo YK

Gangliosides have been suggested to play important roles in various functions such as adhesion, cell differentiation, growth control, and signaling. Mouse follicular development, ovulation, and luteinization during the estrous cycle...
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Role of the epithelial-mesenchymal transition and its effects on embryonic stem cells

Kim YS, Yi BR, Kim NH, Choi KC

The epithelial-mesenchymal transition (EMT) is important for embryonic development and the formation of various tissues or organs. However, EMT dysfunction in normal cells leads to diseases, such as cancer or...
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The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells

Jung JU, Ko K, Lee DH, Ko K, Chang KT, Choo YK

Glycosphingolipids including gangliosides play important regulatory roles in cell proliferation and differentiation. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyze the initial step in glycosphingolipids biosynthesis pathway. In this study, Ugcg expression was reduced...
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