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Recurrent Severe Hyponatremia in a Patient with Sjögren’s Syndrome

Kim HD, Lee J, Chung BH, Yang CW, Kim YS, Park CW

Sjögren's syndrome (SS) is an autoimmune disease that presents with exocrine gland dysfunction. Renal involvement is common in SS and often results in tubulointerstitial nephritis, renal tubular acidosis, and Fanconi’s...
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Extremely Severe Hypernatremia Caused by Wrong Belief in a Patient with Cervical Cancer

Park MS, Park HJ, Choi HS, Kim CS, Bae EH, Ma SK, Kim SW, Kim M

A 56-year old female patient who was undergoing follow-up for cervical cancer in our oncology center was presented to the emergency center with anxiety and excessive thirst. The initial serum...
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Voriconazole-induced Severe Hyperkalemia Precipitated by Multiple Drug Interactions

Choi JY, Cho SG, Jang KS, Kim GH

Voriconazole, a triazole antifungal agent used to treat serious fungal infections, has a pharmacokinetic characteristic of undergoing hepatic metabolism by the cytochrome P450 system. Few cases of hyperkalemia have been...
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Urinary Concentration Defect and Renal Glycosuria in Cyclosporine-treated Rats

Lee JH, Kim SA, Jo CH, Lee CH, Kim GH

Background: Urinary concentration impairment is a major feature of cyclosporine nephrotoxicity. Methods: We explored two possible mechanisms that may underlie cyclosporineinduced polyuria; water, and/or osmotic diuresis. Cyclosporine was subcutaneously injected to...
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