- Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?
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Sanak M
- KMID: 2349987
- Allergy Asthma Immunol Res.
- 2016 Nov;8(6):481-490.
- doi: 10.4168/aair.2016.8.6.481
Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical... -
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- Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism
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Lee SH, Kim EJ, Lee DH, Lee WY, Chung BC, Seo HS, Choi MH
- KMID: 2373554
- Ann Lab Med.
- 2016 Jul;36(4):342-352.
- doi: 10.3343/alm.2016.36.4.342
BACKGROUND: Eicosanoids are metabolites of arachidonic acid that are rapidly biosynthesized and degraded during inflammation, and their metabolic changes reveal altered enzyme expression following drug treatment. We developed an eicosanoid... -
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- Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
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Lu Y, Li X, Park YN, Kwon O, Piao D, Chang YC, Kim CH, Lee E, Son JK, Chang HW
- KMID: 2170636
- Biomol Ther.
- 2014 May;22(3):193-199.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells.... -
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- Effect of Different Amount of Dietary n-3 PUFA on Colon Carcinogenesis in DMH-treated Rats
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Park HS, Kwak HK, Kim MS
- KMID: 2269915
- Korean J Nutr.
- 2005 Dec;38(10):807-816.
The objective of the study was to observe the effect of n-3 PUFA on cell proliferation and apoptosis by determining mRNA and protein of COX-2 and eicosanoid product and the... -
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- Effect of Dietary CLA Isomers on Apoptosis and Cell Proliferation in Colonic Mucosa of DMH-Treated Rats
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Park HS, Kwon PS, Park JH, Ha YL
- KMID: 2269681
- Korean J Nutr.
- 2003 Sep;36(7):661-666.
The study was designed to compare the anti-carcinogenic effect of conjugated linoleic acid (CLA) isomers on colon carcinogenesis in 1,2-dimethylhydrazine (DMH)-treated rats by determining the levels of apoptosis, cell proliferation,... -
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- Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids
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Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH
- KMID: 1804431
- Cancer Res Treat.
- 2001 Oct;33(5):404-413.
PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid... -
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- The Signaling Pathway of G-protein Rac and Eicosanoid Synthesis by Titanium Particles
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Lee SS, Her JY, Woo CH, Kim JH, Chang JD
- KMID: 2105760
- J Korean Orthop Assoc.
- 2001 Aug;36(4):317-325.
PURPOSE: In order to understand the intracellular signaling pathway involving the c-fos gene expression that is caused by Titanium-particles, we analyzed the involvement of Rac, cytosolic phospholipase A2, and eicosanoids... -
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- Changes in the Levels of Eicosanoids and Isoprostane (8-iso-PGF2alpha) in the Newborn Rat Brain after Hypoxic-Ischemic Injury
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Lee HY, Jung MK, Kim JA, Chang YP, Hyun KS, Kim HG, Hwang TJ
- KMID: 2099016
- J Korean Soc Neonatol.
- 2000 May;7(1):45-53.
PURPOSE: The changes in the levels of eicosanoids and isoprostane (8-iso-PGF2alpha) were investigated in brain tissue of 7 day-old rats after hypoxic-ischemic (HI) injury. METHODS: The 7 day-old newborn rats... -
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- Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction
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Kim HG, Huh YN, Park KS
- KMID: 2071837
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram... -
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