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Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

Sanak M

Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical...
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Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism

Lee SH, Kim EJ, Lee DH, Lee WY, Chung BC, Seo HS, Choi MH

BACKGROUND: Eicosanoids are metabolites of arachidonic acid that are rapidly biosynthesized and degraded during inflammation, and their metabolic changes reveal altered enzyme expression following drug treatment. We developed an eicosanoid...
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Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway

Lu Y, Li X, Park YN, Kwon O, Piao D, Chang YC, Kim CH, Lee E, Son JK, Chang HW

  • KMID: 2170636
  • Biomol Ther.
  • 2014 May;22(3):193-199.
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells....
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Effect of Different Amount of Dietary n-3 PUFA on Colon Carcinogenesis in DMH-treated Rats

Park HS, Kwak HK, Kim MS

  • KMID: 2269915
  • Korean J Nutr.
  • 2005 Dec;38(10):807-816.
The objective of the study was to observe the effect of n-3 PUFA on cell proliferation and apoptosis by determining mRNA and protein of COX-2 and eicosanoid product and the...
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Effect of Dietary CLA Isomers on Apoptosis and Cell Proliferation in Colonic Mucosa of DMH-Treated Rats

Park HS, Kwon PS, Park JH, Ha YL

  • KMID: 2269681
  • Korean J Nutr.
  • 2003 Sep;36(7):661-666.
The study was designed to compare the anti-carcinogenic effect of conjugated linoleic acid (CLA) isomers on colon carcinogenesis in 1,2-dimethylhydrazine (DMH)-treated rats by determining the levels of apoptosis, cell proliferation,...
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Effects of Cyclooxygenase and Lipoxygenase Inhibitors on the Proliferation of Colon Cancer Cells and Their Production of Eicosanoids

Lee HS, Kim EJ, Oh YS, Cho HJ, Park JH

  • KMID: 1804431
  • Cancer Res Treat.
  • 2001 Oct;33(5):404-413.
PURPOSE: Epidemiological and laboratory studies suggest that nonsteroidal antiinflammatory drugs (NSAIDs) reduce the risk of colon cancer and that the inhibition of colon cancer is mediated through modulation of eicosanoid...
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The Signaling Pathway of G-protein Rac and Eicosanoid Synthesis by Titanium Particles

Lee SS, Her JY, Woo CH, Kim JH, Chang JD

  • KMID: 2105760
  • J Korean Orthop Assoc.
  • 2001 Aug;36(4):317-325.
PURPOSE: In order to understand the intracellular signaling pathway involving the c-fos gene expression that is caused by Titanium-particles, we analyzed the involvement of Rac, cytosolic phospholipase A2, and eicosanoids...
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Changes in the Levels of Eicosanoids and Isoprostane (8-iso-PGF2alpha) in the Newborn Rat Brain after Hypoxic-Ischemic Injury

Lee HY, Jung MK, Kim JA, Chang YP, Hyun KS, Kim HG, Hwang TJ

  • KMID: 2099016
  • J Korean Soc Neonatol.
  • 2000 May;7(1):45-53.
PURPOSE: The changes in the levels of eicosanoids and isoprostane (8-iso-PGF2alpha) were investigated in brain tissue of 7 day-old rats after hypoxic-ischemic (HI) injury. METHODS: The 7 day-old newborn rats...
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Simultaneous HPLC analysis of arachidonic acid metabolites in biological samples with simple solid phase extraction

Kim HG, Huh YN, Park KS

  • KMID: 2071837
  • Korean J Physiol Pharmacol.
  • 1998 Dec;2(6):779-786.
A reversed-phase high-performance liquid chromatography (RP-HPLC) has been developed to analyze the metabolites of arachidonic acid based on the specificities of ultraviolet absorption of these various metabolites and is sensitive to the nanogram...
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