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Knack and pitfalls in making a mouse model of small intestinal transplantation

Fujita T, Matsushima H, Kosaka T, Soyama A, Miyamoto D, Hidaka M, Eguchi S

In organs transplantation, mouse models are useful tools to analyze transplant biology and immunology because of their well-recognized genetic background and existence of abundant antibodies. At our department, we have...
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Application of engineered cell sheets composed of human islets and supporting stem cells enhances the outcome of islet cell transplantation in vitro and in vivo

Yoshino K, Adachi T, Matsushima, H, Imamura H, Maruya Y, Hara T, Soyama A, Hidaka M, Eguchi S

We have so far conducted various islet transplantation research using cell sheet engineering technique. By using engineered cell sheets composed of human islets and supporting cells, cytoprotective effect on islets...
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Fabrication of Functional Cell Sheets with Human Thyrocytes from Non-Tumorous Thyroid Tissue

Huang Y, Yamanouchi K, Sakai Y, Kuba S, Sakimura C, Morita M, Kanetaka K, Takatsuki , Eguchi S

BACKGROUND: Engineered cell sheet transplantation has been considered an alternative physiological therapy for endocrine disorders. In this study, we attempted to fabricate functional human thyroid cell sheets using the engineering...
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Transplantation of chemically induced liver progenitors as a treatment to ameliorate liver fibrosis

Fukumoto M, Hidaka M, Soyama A, Hara T, Miyamoto D, Matsuguma K, Matsushima H, Imamura H, Adachi T, Eguchi S

Background: Hepatocyte-based regenerative therapy has been reported as an alternative treatment to liver transplantation for end-stage liver disease. We have been investigating the reprogramming of mature hepatocytes to liver progenitors...
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Japanese national survey on declined liver allografts from brain-dead donors: high decline rate but promising outcomes in allografts with moderate steatosis

Takemura Y, Shinoda M, Obara H, Kitago M, Kasahara M, Umeshita K, Eguchi S, Kitagawa Y, Ohdan H, Egawa H

Background: Liver allografts from brain-dead donors which were declined and eventually not transplanted due to accompanying marginal factors have never been surveyed in Japan. We surveyed and characterized the declined...
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