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Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update

Fukui H

Portal blood flows into the liver containing the gut microbiome and its products such as endotoxin and bacterial DNA. The cirrhotic liver acts and detoxifies as the initial site of...
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Dietary modulation of gut microbiota for the relief of irritable bowel syndrome

Kim MY, Choi SW

Irritable bowel syndrome (IBS) is a frequently diagnosed gastrointestinal (GI) disorder characterized by recurrent abdominal pain, bloating, and changes in the stool form or frequency without any structural changes and...
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Analysis of the Conjunctival Microbiome in Patients with Atopic Keratoconjunctivitis and Healthy Individuals

Hur MS, Lee JS, Jang M, Shin HJ, Lee YW

Background: Atopic dermatitis (AD) has been clarified that imbalance of bacterial and fungal communities in the skin and gut play key roles in immunologic dysfunction. Atopic keratoconjunctivitis (AKC), one of...
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Fecal Microbiota Transplantation beyond Clostridioides Difficile Infection

Moon CM, Hong SN

With advancing analytical methods for gut microbes, many studies have been conducted, revealing that gut microbes cause various diseases, including gastrointestinal and non-gastrointestinal diseases. Accordingly, studies have been actively conducted...
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Aging effects on the diurnal patterns of gut microbial composition in male and female mice

Kim HJ, Moon CM, Kang JL, Park EM

Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the...
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The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease

Jennison E, Byrne CD

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2...
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Clinical Significance of Changes in Gut Microbiome Associated with Use of Proton Pump Inhibitors

Kim TJ, Lee H

Proton pump inhibitors (PPIs) are commonly used for the treatment of gastric acid-related disorders, and are generally well tolerated. However, by reducing the secretion of gastric acid in the long...
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Can a Synbiotic Supplementation Contribute to Decreasing Anti-Tissue Transglutaminase Levels in Children with Potential Celiac Disease?

Demiroren K

Purpose: Synbiotics can alleviate some intestinal pathologies or prevent trigger mechanisms for some diseases such as celiac disease (CD). If patients with high levels of anti-tissue transglutaminase (anti-tTG) immunoglobulin A...
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The clinical impact of gut microbiota in chronic kidney disease

Kim SM, Song Ih

Gut microorganisms play critical roles in both maintaining host homeostasis and the development of diverse diseases. Gut dysbiosis, an alteration of the composition and function of gut microorganisms, is commonly...
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Leaky Gut Syndrome

Kim KN, Kim KM

Increased intestinal permeability, termed leaky gut syndrome (LGS), plays an important role in health and disease. LGS creates gaps in the intestinal walls that allow harmful bacteria and toxic substances...
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From intestinal dysbiosis to alcohol-associated liver disease

Mendes BG, Schnabl B

Alcohol-associated intestinal dysbiosis and bacterial overgrowth can lead to a dysregulation of tryptophan metabolism and lower production of indoles. Several of these indole derivatives are aryl hydrocarbon receptor ligands that,...
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5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

Mizuno S, Ono K, Mikami Y, Naganuma M, Fukuda T, Minami K, Masaoka T, Terada S, Yoshida T, Saigusa K, Hirahara N, Miyata H, Suda W, Hattori M, Kanai T

Background/Aims: 5-Aminosalicylic acid (ASA) causes intolerance reactions in some patients. This study was performed to examine the prognosis of patients with ulcerative colitis (UC) and 5-ASA intolerance, and to evaluate...
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Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids

Kim HJ, Lee SH, Hong SJ

PURPOSE: Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in...
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Parkinson's Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation

Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L, Nair PP

  • KMID: 2454635
  • J Neurogastroenterol Motil.
  • 2019 Jul;25(3):363-376.
  • doi: 10.5056/jnm19044
The role of the microbiome in health and human disease has emerged at the forefront of medicine in the 21st century. Over the last 2 decades evidence has emerged to...
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Systemic Sclerosis and Microbiota: Overview of Current Research Trends and Future Perspective

Kim S, Chun SH, Park HJ, Lee SI

The commensal microbiota contributes to the maintenance of immune homeostasis in the human body. Autoimmunity can be aggravated or alleviated by the microbiota, which affects both innate and adaptive immune...
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Impact of microbiota in colorectal carcinogenesis: lessons from experimental models

Yu LC, Wei SC, Ni YH

A role of gut microbiota in colorectal cancer (CRC) growth was first suggested in germ-free rats almost 50 years ago, and the existence of disease-associated bacteria (termed pathobionts) had becoming...
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Is It Useful to Administer Probiotics Together With Proton Pump Inhibitors in Children With Gastroesophageal Reflux?

Belei O, Olariu L, Dobrescu A, Marcovici , Marginean

  • KMID: 2417272
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):51-57.
  • doi: 10.5056/jnm17059
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a frequent condition diagnosed in children and treated with proton pump inhibitors (PPI). Long-term PPI administration can alter intestinal bacterial population by suppressing the...
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Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure

Kamo T, Akazawa H, Suzuki JI, Komuro I

Patients with heart failure (HF) have structural and functional changes of the gut as a result of microcirculatory disturbances. A disrupted gut epithelial barrier may lead to translocation of microbial...
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Fecal microbiota transplantation for refractory Crohn's disease

Bak SH, Choi HH, Lee J, Kim MH, Lee YH, Kim JS, Cho YS

Approximately one-third of patients with Crohn's disease do not respond to conventional treatments, and some experience significant adverse effects, such as serious infections and lymphoma, and many patients require surgery...
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Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy

Ghoshal UC, Shukla R, Ghoshal U

The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is...
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