- Regulatory Roles of MAPK Phosphatases in Cancer
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Low HB, Zhang Y
- KMID: 2168049
- Immune Netw.
- 2016 Apr;16(2):85-98.
- doi: 10.4110/in.2016.16.2.85
The mitogen-activated protein kinases (MAPKs) are key regulators of cell growth and survival in physiological and pathological processes. Aberrant MAPK signaling plays a critical role in the development and progression... -
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- Role of Extracellular Signal-Regulated Kinase 1/2 and Reactive Oxygen Species in Toll-Like Receptor 2-Mediated Dual-Specificity Phosphatase 4 Expression
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Kim SY, Baek SH
- KMID: 2320038
- Yeungnam Univ J Med.
- 2013 Jun;30(1):10-16.
BACKGROUND: Toll-like receptors (TLRs) are well-known pattern recognition receptors. Among the 13 TLRs, TLR2 is the most known receptor for immune response. It activates mitogen-activated protein kinases (MAPKs), which are... -
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- microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
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Lee H, Kim C, Kang H, Tak H, Ahn S, Yoon SK, Kuh HJ, Kim W, Lee EK
- KMID: 2382689
- Exp Mol Med.
- 2017 May;49(5):e327.
- doi: 10.1038/emm.2017.33
Acquisition of resistance to anti-cancer drugs is a significant obstacle to effective cancer treatment. Although several efforts have been made to overcome drug resistance in cancer cells, the detailed mechanisms... -
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- Clinical Analysis of PTEN, p53 and Her-2/neu Expressions in Thyroid Cancers
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Kim JS, Bae JS, Kim KH, Ahn CH, Oh SJ, Jeon HM, Lim KW, Chun CS
- KMID: 1804435
- Cancer Res Treat.
- 2001 Oct;33(5):433-437.
PURPOSE: The dual-specificity phosphatase PTEN/ MMAC1/TEP1 has recently been identified as the tumor suppressor gene most frequently mutated and/or deleted in human tumors. However, PTEN mutations have rarely been detected... -
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- Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure
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Choi JR, Koh SB, Park SY, Kim HR, Lee H, Kang DR
- KMID: 2434285
- J Cancer Prev.
- 2017 Dec;22(4):234-240.
- doi: 10.15430/JCP.2017.22.4.234
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic... -
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- cDNA Microarray Analysis of Differential Gene Expression in Gastric Cancer Cells Sensitive and Resistant to 5-Fluorouracil and Cisplatin
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Ahn MJ, Yoo YD, Lee KH, Ahn JI, Yu DH, Lee HS, Oh HS, Choi JH, Lee YS
- KMID: 1743356
- Cancer Res Treat.
- 2005 Feb;37(1):54-62.
PURPOSE: Gastric cancer is one of the most prevalent cancers worldwide. 5-fluorouracil (5-FU) and cisplatin are the most commonly used drugs for the treatment of gastric cancer. However, a significant... -
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