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New conceptual approaches toward dentin regeneration using the drug repositioning strategy with Wnt signaling pathways

Lee ES, Kim TY, Aryal YP, Kim K, Byun S, Song D, Shin Y, Lee D, Lee J, Jung G, Chi S, Choi Y, Lee Y, An CH, Kim JY

This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent...
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COVID-19 Antiviral and Treatment Candidates: Current Status

Españo E, Kim D, Kim J, Park SK, Kim JK

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 has severely impacted global health and economy. There is currently no effective approved treatment for...
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Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis

Prakash AV, Park JW, Seong JW, Kang TJ

The process of drug discovery and drug development consumes billions of dollars to bring a new drug to the market. Drug development is time consuming and sometimes, the failure rates...
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Anti-inflammatory Strategies for Schizophrenia: A Review of Evidence for Therapeutic Applications and Drug Repurposing

Hong J, Bang M

Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and humanistic burden. Currently available treatment strategies mostly rely on antipsychotic drugs, which block dopaminergic effects in the mesolimbic pathway...
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A review of computational drug repurposing

Park K

Although sciences and technology have progressed rapidly, de novo drug development has been a costly and time-consuming process over the past decades. In view of these circumstances, ‘drug repurposing’ (or...
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Guanabenz Acetate Induces Endoplasmic Reticulum Stress–Related Cell Death in Hepatocellular Carcinoma Cells

Kang HJ, Seol HS, Lee SE, Suh YA, Kim J, Jang SJ, Yu E

BACKGROUND: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for...
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Current state and outlook for drug repositioning anticipated in the field of ovarian cancer

Kobayashi , Banno K, Kunitomi H, Tominaga E, Aoki D

Ovarian cancer is the seventh most common cancer and the eighth most common cause of cancer mortality in women. Although standard chemotherapy is the established treatment for ovarian cancer, the...
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Drug Similarity Search Based on Combined Signatures in Gene Expression Profiles

Cha K, Kim MS, Oh K, Shin H, Yi GS

OBJECTIVES: Recently, comparison of drug responses on gene expression has been a major approach to identifying the functional similarity of drugs. Previous studies have mostly focused on a single feature,...
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