- Evolutionary and Comparative Genomics to Drive Rational Drug Design, with Particular Focus on Neuropeptide Seven-Transmembrane Receptors
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Furlong M, Seong JY
- KMID: 2367619
- Biomol Ther.
- 2017 Jan;25(1):57-68.
- doi: 10.4062/biomolther.2016.199
Seven transmembrane receptors (7TMRs), also known as G protein-coupled receptors, are popular targets of drug development, particularly 7TMR systems that are activated by peptide ligands. Although many pharmaceutical drugs have... -
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- New antiepileptic drugs: I. Basic characteristics
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Lee BI
- KMID: 644936
- J Korean Med Sci.
- 1996 Apr;11(2):99-110.
- doi: 10.3346/jkms.1996.11.2.99
No abstract available. -
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- Therapeutic Modulation of Apoptosis: Targeting the BCL-2 Family at the Interface of the Mitochondrial Membrane
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Nemec KN, Khaled AR
- KMID: 2158185
- Yonsei Med J.
- 2008 Oct;49(5):689-697.
- doi: 10.3349/ymj.2008.49.5.689
A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely,... -
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- Promise of Neurorestoration and Mitochondrial Biogenesis in Parkinson's Disease with Multi Target Drugs: An Alternative to Stem Cell Therapy
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Youdim MB, Oh YJ
- KMID: 2165480
- Exp Neurobiol.
- 2013 Sep;22(3):167-172.
- doi: 10.5607/en.2013.22.3.167
There is an unmet need in progressive neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. The present therapeutics for these diseases at best is symptomatic and is not able to... -
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- hpvPDB: An Online Proteome Reserve for Human Papillomavirus
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Kumar S, Jena L, Daf S, Mohod K, Goyal P, Varma AK
- KMID: 2166515
- Genomics Inform.
- 2013 Dec;11(4):289-291.
- doi: 10.5808/GI.2013.11.4.289
Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host... -
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- Molecular Characterization of Legionellosis Drug Target Candidate Enzyme Phosphoglucosamine Mutase from Legionella pneumophila (strain Paris): An In Silico Approach
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Hasan A, Mazumder H, Khan A, Hossain MU, Chowdhury
- KMID: 2391507
- Genomics Inform.
- 2014 Dec;12(4):268-275.
- doi: 10.5808/GI.2014.12.4.268
The harshness of legionellosis differs from mild Pontiac fever to potentially fatal Legionnaire's disease. The increasing development of drug resistance against legionellosis has led to explore new novel drug targets.... -
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- Erratum: The Effect of Lowering the Threshold for Diagnosis of Impaired Fasting Glucose
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Kim SH, Shim WS, Kim EA, Kim EJ, Lee SH, Hong SB, Kim YS, Park SG, Leem JH, Lee HJ, Nam M
- KMID: 1793210
- Yonsei Med J.
- 2008 Aug;49(4):687-687.
- doi: 10.3349/ymj.2008.49.4.687
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- Molecular Application in Psychiatry
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Choi IG
- KMID: 1899244
- J Korean Soc Biol Psychiatry.
- 2000 Nov;7(2):115-122.
The development of molecular biology has brought many changes in psychiatry. Molecular biology makes us possible to know the cause of mental disorders that provide the way to prevent the... -
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- Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
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Khaw KY, Murugaiyah V, Khairuddean M, Tan WN
- KMID: 2416067
- Nat Prod Sci.
- 2018 Jun;24(2):88-92.
- doi: 10.20307/nps.2018.24.2.88
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in... -
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- Virtual Screening for Potential Inhibitors of NS3 Protein of Zika Virus
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Sahoo M, Jena L, Daf S, Kumar S
- KMID: 2353662
- Genomics Inform.
- 2016 Sep;14(3):104-111.
- doi: 10.5808/GI.2016.14.3.104
Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause... -
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- Induced pluripotent stem cells and personalized medicine: current progress and future perspectives
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Chun YS, Byun K, Lee B
- KMID: 1447438
- Anat Cell Biol.
- 2011 Dec;44(4):245-255.
- doi: 10.5115/acb.2011.44.4.245
Generation of induced pluripotent stem cells (iPSCs) has revolutionized the field of regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. iPSCs can... -
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- Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
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Seo YH
- KMID: 2171313
- J Cancer Prev.
- 2015 Mar;20(1):5-11.
- doi: 10.15430/JCP.2015.20.1.5
Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins including epidermal growth... -
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- Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Toxoplasma gondii Apical Membrane Antigen 1 (AMA1)
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Vetrivel U, Muralikumar S, Mahalakshmi B, Lily Therese K, Madhavan H, Alameen M, Thirumudi
- KMID: 2328166
- Genomics Inform.
- 2016 Jun;14(2):53-61.
- doi: 10.5808/GI.2016.14.2.53
Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by... -
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- Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies
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di Luccio
- KMID: 2171336
- J Cancer Prev.
- 2015 Jun;20(2):113-120.
- doi: 10.15430/JCP.2015.20.2.113
BACKGROUND: Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 (NSD2) is a lysine histone methyltransferase (HMTase) and bona fide oncoprotein found aberrantly expressed in several cancers, suggesting potential... -
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- The Role of Pharmacoethnicity in the Development of Cytotoxic and Molecular Targeted Drugs in Oncology
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Saijo N
- KMID: 1776911
- Yonsei Med J.
- 2013 Jan;54(1):1-14.
- doi: 10.3349/ymj.2013.54.1.1
The effective and toxic ranges of anticancer drugs are very narrow and, in some cases, inverted. Thus determination of the most appropriate dosage and schedule of administration is crucial for... -
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- Chemicals as the Sole Transformers of Cell Fate
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Ebrahimi B
- KMID: 2164156
- Int J Stem Cells.
- 2016 May;9(1):9-20.
- doi: 10.15283/ijsc.2016.9.1.9
Forced expression of lineage-specific transcription factors in somatic cells can result in the generation of different cell types in a process named direct reprogramming, bypassing the pluripotent state. However, the... -
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- Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis
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Kumar S, Jena L, Galande S, Daf S, Mohod K, Varma AK
- KMID: 2026461
- Genomics Inform.
- 2014 Jun;12(2):64-70.
- doi: 10.5808/GI.2014.12.2.64
Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The life-threatening infection caused by HPV demands the need for designing anticancerous drugs. In the recent... -
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- Modifiers of TGF-beta1 effector function as novel therapeutic targets of pulmonary fibrosis
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Lee CM, Park JW, Cho WK, Zhou Y, Han B, Yoon PO, Chae J, Elias JA, Lee CG
- KMID: 1792051
- Korean J Intern Med.
- 2014 May;29(3):281-290.
- doi: 10.3904/kjim.2014.29.3.281
Pulmonary fibrosis is a fatal progressive disease with no effective therapy. Transforming growth factor (TGF)-beta1 has long been regarded as a central mediator of tissue fibrosis that involves multiple organs... -
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- In Silico Docking to Explicate Interface between Plant-Originated Inhibitors and E6 Oncogenic Protein of Highly Threatening Human Papillomavirus 18
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Kumar S, Jena L, Sahoo M, Kakde M, Daf S, Varma AK
- KMID: 2009148
- Genomics Inform.
- 2015 Jun;13(2):60-67.
- doi: 10.5808/GI.2015.13.2.60
The leading cause of cancer mortality globally amongst the women is due to human papillomavirus (HPV) infection. There is need to explore anti-cancerous drugs against this life-threatening infection. Traditionally, different... -
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