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Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin

Lee JE, Jang H, Cho EJ, Youn HD

Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage....
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