- Atractylochromene Is a Repressor of Wnt/beta-Catenin Signaling in Colon Cancer Cells
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Shim AR, Dong GZ, Lee HJ, Ryu JH
- KMID: 2380359
- Biomol Ther.
- 2015 Jan;23(1):26-30.
- doi: 10.4062/biomolther.2014.095
Wnt/beta-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated beta-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the... -
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- beta-Lapachone suppresses radiation-induced activation of nuclear factor-kappaB
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Dong GZ, Oh ET, Lee H, Park MT, Song CW, Park HJ
- KMID: 946632
- Exp Mol Med.
- 2010 May;42(5):327-334.
- doi: 10.3858/emm.2010.42.5.034
Anticancer effects of beta-lapachone (beta-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced forms of... -
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