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Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors

Lee CH, Kweon OK

  • KMID: 1097349
  • J Vet Sci.
  • 2002 Dec;3(4):321-325.
Mutation of the p53 tumor suppressor gene has been related in the pathogenesis of numerous human and canine cancers, including breast cancers and mammary tumors. We have investigated exons 5-8...
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TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor

Sanchez-Servin A, Martinez S, Cordova-Alarcon E, Fajardo R

The canine transmissible venereal tumor (CTVT) is found mainly in dogs' sexual organs. Currently, it is widely accepted that all samples of CTVT show similar histopathological characteristics and share common...
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Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor

Choi YK, Kim CJ

  • KMID: 1097345
  • J Vet Sci.
  • 2002 Dec;3(4):285-292.
LINEs (long interspersed nuclear elements or long interspersed repeated DNA elements) contains two open reading frames (ORFs), ORF1 and ORF2. We analysed the ORF2 located in the 5' region to...
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Color-dilution alopecia in dogs

Kim JH, Kang KI, Sohn HJ, Woo GH, Jean YH, Hwang EK

  • KMID: 1091211
  • J Vet Sci.
  • 2005 Sep;6(3):259-261.
Color-dilution alopecia is a relatively uncommon hereditary skin disease seen in "Blue" and other color-diluted dogs. This syndrome is associated with a color-dilution gene. The initial clinical signs are the...
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The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study

Huang J, Zhang D, Xie F, Lin D

Increasing evidence suggests that cancer stem cells (CSCs) are responsible for tumor initiation and maintenance. Additionally, it is becoming apparent that cyclooxygenase (COX) signaling is associated with canine mammary tumor...
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Inherited canine copper toxicosis in Australian Bedlington Terriers

Hyun C, Filippich

  • KMID: 1094684
  • J Vet Sci.
  • 2004 Mar;5(1):19-28.
Inherited copper toxicosis in Bedlington Terriers (CTBT) is a copper associated hepatopathy caused by an autosomal recessive genetic defect of gene involving copper metabolism. To compare clinical and histopathological findings...
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