- The Metabolism and Liver Toxicity of N,N-dimethylformamide in the Isolated Perfused Rat Liver
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Koh SB, Cha BS, Park JK, Chang SH, Chang SJ
- KMID: 1122008
- Yonsei Med J.
- 2002 Aug;43(4):491-499.
- doi: 10.3349/ymj.2002.43.4.491
N,N-dimethylformamide (DMF) is metabolized by the microsomal cytochrome p-450 into mainly N-hydroxymethyl- N-methylformamide (HMMF), which further breaks down to N-methyformamide (NMF). However, the detailed mechanism of its toxicity remains unclear.... -
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