- A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL)
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Heo YS, Song HJ, Oh CH
- KMID: 2247720
- Korean J Dermatol.
- 2010 Feb;48(2):155-157.
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase,... -
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- A Case of 5-Fluorouracil Induced Encephalopathy
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Kwon KA, Kwon HC, Kim MC, Kim SH, Oh SY, Lee S, Kim HJ
- KMID: 2165968
- Cancer Res Treat.
- 2010 Jun;42(2):118-120.
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU.... -
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- Unpredicted Severe Toxicity after 5-Fluorouracil Treatment due to Dihydropyrimidine Dehydrogenase Deficiency
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Baek JH, Kim JG, Kim SN, Kim DH, Sohn SK, Hong YJ, Lee KB
- KMID: 1782251
- Korean J Intern Med.
- 2006 Mar;21(1):43-45.
- doi: 10.3904/kjim.2006.21.1.43
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU). Thus, patients with a DPD deficiency are at risk of developing severe 5-FU-associated toxicity. A... -
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- Screening of Dihydropyrimidine Dehydrogenase Genetic Variants by Direct Sequencing in Different Ethnic Groups
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Shin JG, Cheong HS, Kim JY, Kim LH, Han CS, Kim JO, Kim HD, Kim YH, Chung MW, Han SY, Shin HD
- KMID: 1793015
- J Korean Med Sci.
- 2013 Aug;28(8):1129-1133.
- doi: 10.3346/jkms.2013.28.8.1129
Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution... -
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- Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer
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Xu R, He X, Wufuli R, Su Y, Ma L, Chen R, Han Z, Wang F, Liu J
- KMID: 2466029
- J Gastric Cancer.
- 2019 Dec;19(4):408-416.
- doi: 10.5230/jgc.2019.19.e40
PURPOSE: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. MATERIALS AND METHODS: Eighty-six patients... -
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- Relationship between Microsatellite Instability and Dihydropyrimidine Dehydrogenase Expression as a Predictor of Response to 5-Fluorouracil Chemotherapy for Colorectal Cancer
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Rhyou JH, Lee SH, Lee WI, Lee RA, Kim KH, Chung SS, Park EB
- KMID: 2101392
- J Korean Soc Coloproctol.
- 2005 Jun;21(3):157-166.
PURPOSE: Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in 5-FU catabolism, so the enzymatic activity of DPD reflects the 5-FU response. Moreover, recent studies have revealed that microsatellite instability (MSI)... -
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